HIPHOP chemogenomics database

YJL100W / LSB6

Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL100W / LSB6

Click on Significant Values for Screen Details

Top fitness defect scores for YJL100W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2694	st077685	10.90	81.9 µM	2.53E-27	endomembrane recycling	4	5.83E-28
2	SGTC_2690	usnic acid	9.50	100.0 µM	3.48E-21		1	1.07E-21
3	SGTC_1390	3413-2614	6.48	145.0 µM	8.54E-11	fatty acid desaturase (OLE1)	2	4.44E-11
4	SGTC_1144	3486-0183	6.31	12.5 µM	2.60E-10		5	1.39E-10
5	SGTC_2636	apigenin dimethyl ether	5.32	100.0 µM	8.44E-8		14	5.17E-8
6	SGTC_2486	5283202	4.91	22.4 µM	7.03E-7		22	4.54E-7
7	SGTC_265	mycophenolic acid	4.76	32.9 µM	1.46E-6	RPP1 & pyrimidine depletion	5	9.61E-7
8	SGTC_39	0986-0283	4.40	58.4 µM	8.02E-6	calcium & mitochondrial duress	24	5.50E-6
9	SGTC_2862	9027634	4.30	71.4 µM	1.24E-5	ERG2	22	8.58E-6
10	SGTC_1599	8-chlro-1-tetrahydronorharmanone	4.25	90.6 µM	1.53E-5		28	1.07E-5
11	SGTC_988	1497-1057	4.24	103.0 µM	1.57E-5		8	1.10E-5
12	SGTC_872	0588-0139	4.24	234.0 µM	1.60E-5		24	1.12E-5
13	SGTC_1131	3454-3128	4.21	32.3 µM	1.81E-5		32	1.27E-5
14	SGTC_2851	9015922	4.18	71.4 µM	2.05E-5		31	1.44E-5
15	SGTC_1636	st007707	4.18	68.9 µM	2.10E-5		45	1.48E-5
16	SGTC_2724	maprotiline	4.18	69.6 µM	2.11E-5	ERG2	11	1.48E-5
17	SGTC_3205	9113483	4.12	49.5 µM	2.63E-5		22	1.86E-5
18	SGTC_2154	5570129	4.12	200.0 µM	2.68E-5		14	1.90E-5
19	SGTC_2981	9013952	4.10	39.0 µM	2.90E-5		41	2.06E-5
20	SGTC_2283	7944793	3.99	200.0 µM	4.60E-5		40	3.30E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.096	2.39E-8	YPR086W	SUA7	het	Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
0.096	2.97E-8	YJL057C	IKS1	hom	Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.094	5.09E-8	YJL067W_d	YJL067W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093	7.16E-8	YML116W	ATR1	hom	Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.086	5.31E-7	YCL029C	BIK1	hom	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
0.086	6.30E-7	YKL128C	PMU1	hom	Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.082	1.74E-6	YGR238C	KEL2	hom	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
0.082	1.78E-6	YDR496C	PUF6	hom	Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis
0.080	3.63E-6	YKL004W	AUR1	het	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.080	3.75E-6	YJR116W_p	TDA4_p	hom	Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.079	4.49E-6	YJR070C	LIA1	hom	Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress
0.078	5.57E-6	YKL141W	SDH3	het	Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
0.078	6.92E-6	YPL015C	HST2	hom	Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export
0.076	9.20E-6	YBR065C	ECM2	hom	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
0.076	9.44E-6	YNR066C_p	YNR066C_p	hom	Putative membrane-localized protein of unknown function