YJL100W / LSB6

Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL100W / LSB6

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.40|P-value:8.02E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:3.38|P-value:4.80E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.76|P-value:1.46E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:3.81|P-value:9.35E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.66|P-value:1.70E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.26|P-value:7.08E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.49|P-value:3.17E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.39|P-value:4.63E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.25|P-value:7.57E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.74|P-value:1.24E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.24|P-value:1.60E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.57|P-value:2.39E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:4.24|P-value:1.57E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.20|P-value:1.24E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.24|P-value:5.61E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.21|P-value:1.81E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.38|P-value:3.33E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.31|P-value:2.60E-10 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.79|P-value:1.03E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.09|P-value:9.13E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.73|P-value:1.29E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.63|P-value:1.93E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.34|P-value:5.47E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.30|P-value:4.46E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.17|P-value:7.16E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.97|P-value:3.43E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:6.48|P-value:8.54E-11 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.88|P-value:7.07E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.58|P-value:2.30E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.25|P-value:1.53E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.18|P-value:2.10E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.48|P-value:3.28E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.61|P-value:2.02E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.48|P-value:3.32E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.63|P-value:1.91E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.12|P-value:2.68E-5 ID:SGTC_2253|Compound:7938677|FD-Score:-3.27|P-value:4.94E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.95|P-value:5.50E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.99|P-value:4.60E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.19|P-value:9.27E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.97|P-value:5.04E-5 ID:SGTC_2486|Compound:5283202|FD-Score:4.91|P-value:7.03E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.33|P-value:5.65E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.20|P-value:8.72E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.47|P-value:3.38E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.23|P-value:5.81E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.32|P-value:8.44E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:9.50|P-value:3.48E-21 ID:SGTC_2694|Compound:st077685|FD-Score:10.90|P-value:2.53E-27 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.18|P-value:2.11E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.43|P-value:4.03E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.19|P-value:9.27E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.17|P-value:9.86E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.18|P-value:2.05E-5 ID:SGTC_2862|Compound:9027634|FD-Score:4.30|P-value:1.24E-5 ID:SGTC_2883|Compound:9059145|FD-Score:-4.53|P-value:2.75E-6 ID:SGTC_2890|Compound:9046729|FD-Score:-4.12|P-value:1.77E-5 ID:SGTC_2892|Compound:9047358|FD-Score:-3.77|P-value:7.57E-5 ID:SGTC_2981|Compound:9013952|FD-Score:4.10|P-value:2.90E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-3.87|P-value:5.16E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.12|P-value:2.63E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.50|P-value:2.17E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.40|P-value:8.02E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:3.38|P-value:4.80E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.76|P-value:1.46E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:3.81|P-value:9.35E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.66|P-value:1.70E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.26|P-value:7.08E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.49|P-value:3.17E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.39|P-value:4.63E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.25|P-value:7.57E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.74|P-value:1.24E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.24|P-value:1.60E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.57|P-value:2.39E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:4.24|P-value:1.57E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.20|P-value:1.24E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.24|P-value:5.61E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.21|P-value:1.81E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.38|P-value:3.33E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.31|P-value:2.60E-10 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.79|P-value:1.03E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.09|P-value:9.13E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.73|P-value:1.29E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.63|P-value:1.93E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.34|P-value:5.47E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.30|P-value:4.46E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.17|P-value:7.16E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:-3.97|P-value:3.43E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:6.48|P-value:8.54E-11 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.88|P-value:7.07E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.58|P-value:2.30E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.25|P-value:1.53E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.18|P-value:2.10E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.48|P-value:3.28E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.61|P-value:2.02E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.48|P-value:3.32E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.63|P-value:1.91E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.12|P-value:2.68E-5 ID:SGTC_2253|Compound:7938677|FD-Score:-3.27|P-value:4.94E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.95|P-value:5.50E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.99|P-value:4.60E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.19|P-value:9.27E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.97|P-value:5.04E-5 ID:SGTC_2486|Compound:5283202|FD-Score:4.91|P-value:7.03E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.33|P-value:5.65E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.20|P-value:8.72E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.47|P-value:3.38E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.23|P-value:5.81E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.32|P-value:8.44E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:9.50|P-value:3.48E-21 ID:SGTC_2694|Compound:st077685|FD-Score:10.90|P-value:2.53E-27 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.18|P-value:2.11E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.43|P-value:4.03E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.19|P-value:9.27E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.17|P-value:9.86E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.18|P-value:2.05E-5 ID:SGTC_2862|Compound:9027634|FD-Score:4.30|P-value:1.24E-5 ID:SGTC_2883|Compound:9059145|FD-Score:-4.53|P-value:2.75E-6 ID:SGTC_2890|Compound:9046729|FD-Score:-4.12|P-value:1.77E-5 ID:SGTC_2892|Compound:9047358|FD-Score:-3.77|P-value:7.57E-5 ID:SGTC_2981|Compound:9013952|FD-Score:4.10|P-value:2.90E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-3.87|P-value:5.16E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.12|P-value:2.63E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.50|P-value:2.17E-4

Top fitness defect scores for YJL100W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2694 st077685 10.90 81.9 µM 2.53E-27 endomembrane recycling 4 5.83E-28
2 SGTC_2690 usnic acid 9.50 100.0 µM 3.48E-21 1 1.07E-21
3 SGTC_1390 3413-2614 6.48 145.0 µM 8.54E-11 fatty acid desaturase (OLE1) 2 4.44E-11
4 SGTC_1144 3486-0183 6.31 12.5 µM 2.60E-10 5 1.39E-10
5 SGTC_2636 apigenin dimethyl ether 5.32 100.0 µM 8.44E-8 14 5.17E-8
6 SGTC_2486 5283202 4.91 22.4 µM 7.03E-7 22 4.54E-7
7 SGTC_265 mycophenolic acid 4.76 32.9 µM 1.46E-6 RPP1 & pyrimidine depletion 5 9.61E-7
8 SGTC_39 0986-0283 4.40 58.4 µM 8.02E-6 calcium & mitochondrial duress 24 5.50E-6
9 SGTC_2862 9027634 4.30 71.4 µM 1.24E-5 ERG2 22 8.58E-6
10 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.25 90.6 µM 1.53E-5 28 1.07E-5
11 SGTC_988 1497-1057 4.24 103.0 µM 1.57E-5 8 1.10E-5
12 SGTC_872 0588-0139 4.24 234.0 µM 1.60E-5 24 1.12E-5
13 SGTC_1131 3454-3128 4.21 32.3 µM 1.81E-5 32 1.27E-5
14 SGTC_2851 9015922 4.18 71.4 µM 2.05E-5 31 1.44E-5
15 SGTC_1636 st007707 4.18 68.9 µM 2.10E-5 45 1.48E-5
16 SGTC_2724 maprotiline 4.18 69.6 µM 2.11E-5 ERG2 11 1.48E-5
17 SGTC_3205 9113483 4.12 49.5 µM 2.63E-5 22 1.86E-5
18 SGTC_2154 5570129 4.12 200.0 µM 2.68E-5 14 1.90E-5
19 SGTC_2981 9013952 4.10 39.0 µM 2.90E-5 41 2.06E-5
20 SGTC_2283 7944793 3.99 200.0 µM 4.60E-5 40 3.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.39E-8 YPR086W SUA7 het Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
0.096 2.97E-8 YJL057C IKS1 hom Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.094 5.09E-8 YJL067W_d YJL067W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.16E-8 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.086 5.31E-7 YCL029C BIK1 hom Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
0.086 6.30E-7 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.082 1.74E-6 YGR238C KEL2 hom Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
0.082 1.78E-6 YDR496C PUF6 hom Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis
0.080 3.63E-6 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.080 3.75E-6 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.079 4.49E-6 YJR070C LIA1 hom Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress
0.078 5.57E-6 YKL141W SDH3 het Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
0.078 6.92E-6 YPL015C HST2 hom Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export
0.076 9.20E-6 YBR065C ECM2 hom Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
0.076 9.44E-6 YNR066C_p YNR066C_p hom Putative membrane-localized protein of unknown function