YJL119C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL119C / YJL119C

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:5.33|P-value:1.37E-9 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-4.01|P-value:3.56E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.72|P-value:1.56E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-2.95|P-value:4.63E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.31|P-value:1.04E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.45|P-value:5.56E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.61|P-value:2.66E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:2.90|P-value:6.21E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.54|P-value:3.62E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.60|P-value:2.95E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.47|P-value:5.06E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.31|P-value:1.06E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.81|P-value:8.08E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.48|P-value:4.75E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:7.54|P-value:1.77E-17 ID:SGTC_862|Compound:0452-0056|FD-Score:2.96|P-value:4.74E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.65|P-value:2.31E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.18|P-value:1.91E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:2.83|P-value:7.87E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.95|P-value:4.72E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:4.41|P-value:4.28E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.01|P-value:3.68E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.84|P-value:9.03E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.09|P-value:2.84E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.63|P-value:2.55E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.23|P-value:1.48E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.00|P-value:3.83E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.17|P-value:2.07E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-2.95|P-value:4.64E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-2.78|P-value:9.17E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.06|P-value:3.24E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.86|P-value:7.69E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-2.89|P-value:6.07E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.89|P-value:6.53E-6 ID:SGTC_2184|Compound:6075246|FD-Score:2.85|P-value:7.47E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.20|P-value:1.76E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-7.25|P-value:2.51E-16 ID:SGTC_2416|Compound:tofa|FD-Score:3.07|P-value:3.02E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.25|P-value:1.07E-6 ID:SGTC_2484|Compound:5809818|FD-Score:-2.76|P-value:9.88E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.06|P-value:3.01E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.22|P-value:1.53E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.78|P-value:9.20E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.41|P-value:6.62E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.21|P-value:1.73E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.09|P-value:2.88E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.93|P-value:5.74E-6 ID:SGTC_3334|Compound:9142812|FD-Score:2.83|P-value:8.11E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:5.33|P-value:1.37E-9 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-4.01|P-value:3.56E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.72|P-value:1.56E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-2.95|P-value:4.63E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.31|P-value:1.04E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.45|P-value:5.56E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.61|P-value:2.66E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:2.90|P-value:6.21E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.54|P-value:3.62E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.60|P-value:2.95E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.47|P-value:5.06E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.31|P-value:1.06E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.81|P-value:8.08E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.48|P-value:4.75E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:7.54|P-value:1.77E-17 ID:SGTC_862|Compound:0452-0056|FD-Score:2.96|P-value:4.74E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.65|P-value:2.31E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.18|P-value:1.91E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:2.83|P-value:7.87E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.95|P-value:4.72E-6 ID:SGTC_1120|Compound:ficusin|FD-Score:4.41|P-value:4.28E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.01|P-value:3.68E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.84|P-value:9.03E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.09|P-value:2.84E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.63|P-value:2.55E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.23|P-value:1.48E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.00|P-value:3.83E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.17|P-value:2.07E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-2.95|P-value:4.64E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-2.78|P-value:9.17E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.06|P-value:3.24E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.86|P-value:7.69E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-2.89|P-value:6.07E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.89|P-value:6.53E-6 ID:SGTC_2184|Compound:6075246|FD-Score:2.85|P-value:7.47E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.20|P-value:1.76E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-7.25|P-value:2.51E-16 ID:SGTC_2416|Compound:tofa|FD-Score:3.07|P-value:3.02E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.25|P-value:1.07E-6 ID:SGTC_2484|Compound:5809818|FD-Score:-2.76|P-value:9.88E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.06|P-value:3.01E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.22|P-value:1.53E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.78|P-value:9.20E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.41|P-value:6.62E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.21|P-value:1.73E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.09|P-value:2.88E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.93|P-value:5.74E-6 ID:SGTC_3334|Compound:9142812|FD-Score:2.83|P-value:8.11E-4

Top fitness defect scores for YJL119C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_845 0330-0138 7.54 4.5 µM 1.77E-17 4 2.28E-14
2 SGTC_67 0335-0847 5.33 266.0 µM 1.37E-9 ubiquinone biosynthesis & proteasome 81 5.03E-8
3 SGTC_1120 ficusin 4.41 1.8 µM 4.28E-7 16 5.19E-6
4 SGTC_2420 aureobasidin a 4.25 50.0 nM 1.07E-6 33 1.09E-5
5 SGTC_3131 9127911 3.93 49.5 µM 5.74E-6 30 4.23E-5
6 SGTC_1215 3852-0577 3.84 11.2 µM 9.03E-6 18 6.11E-5
7 SGTC_917 harmaline 3.65 728.1 nM 2.31E-5 ergosterol biosynthesis 36 1.31E-4
8 SGTC_1586 deoxycorticosterone acetate 3.63 53.7 µM 2.55E-5 18 1.42E-4
9 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.60 8.0 µM 2.95E-5 35 1.59E-4
10 SGTC_2993 9054257 3.21 71.4 µM 1.73E-4 fatty acid desaturase (OLE1) 82 6.71E-4
11 SGTC_2245 6637752 3.20 200.0 µM 1.76E-4 33 6.80E-4
12 SGTC_925 2064-1272 3.18 59.6 µM 1.91E-4 51 7.26E-4
13 SGTC_1691 st019933 3.17 84.6 µM 2.07E-4 38 7.74E-4
14 SGTC_1381 2324-0066 3.09 62.1 µM 2.84E-4 68 0.00100
15 SGTC_3124 9127567 3.09 49.5 µM 2.88E-4 DNA damage response 46 0.00101
16 SGTC_2416 tofa 3.07 880.0 nM 3.02E-4 sphingolipid biosynthesis & PDR1 95 0.00105
17 SGTC_1886 st057356 3.06 49.9 µM 3.24E-4 60S ribosome export 48 0.00112
18 SGTC_862 0452-0056 2.96 10.2 µM 4.74E-4 azole & statin 72 0.00152
19 SGTC_371 0195-0006 2.90 7.4 µM 6.21E-4 66 0.00189
20 SGTC_2184 6075246 2.85 200.0 µM 7.47E-4 76 0.00220

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 1.03E-42 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.175 2.08E-24 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.138 1.26E-15 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.137 1.50E-15 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.136 2.09E-15 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.131 3.05E-14 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.123 9.72E-13 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.121 2.08E-12 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.121 2.09E-12 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.119 3.96E-12 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.118 6.29E-12 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.115 2.01E-11 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.113 4.66E-11 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.112 7.17E-11 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.111 1.03E-10 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data