YJL122W / ALB1

Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL122W / ALB1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.47|P-value:6.95E-5 ID:SGTC_110|Compound:0850-0284|FD-Score:2.94|P-value:5.98E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.85|P-value:1.20E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.22|P-value:2.60E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.48|P-value:8.75E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.27|P-value:2.07E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-2.94|P-value:7.64E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:2.92|P-value:6.50E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.74|P-value:1.00E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:-4.01|P-value:7.26E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.25|P-value:1.75E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:2.98|P-value:5.27E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.47|P-value:8.88E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.22|P-value:1.97E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.13|P-value:4.08E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:2.96|P-value:5.60E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.90|P-value:1.27E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.78|P-value:1.65E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:3.11|P-value:3.15E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.94|P-value:6.06E-11 ID:SGTC_1112|Compound:tnp00069|FD-Score:2.92|P-value:6.56E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.10|P-value:4.19E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.01|P-value:4.60E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.34|P-value:1.53E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.21|P-value:2.64E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.13|P-value:2.83E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.49|P-value:6.23E-5 ID:SGTC_2217|Compound:6934799|FD-Score:3.17|P-value:2.41E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.78|P-value:1.62E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.72|P-value:2.21E-5 ID:SGTC_2379|Compound:9035213|FD-Score:2.83|P-value:9.13E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.18|P-value:2.33E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.86|P-value:8.34E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.28|P-value:1.55E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.77|P-value:1.76E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.28|P-value:1.54E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.10|P-value:3.18E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.10|P-value:3.23E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.49|P-value:8.36E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-5.12|P-value:1.50E-8 ID:SGTC_2884|Compound:9058502|FD-Score:3.08|P-value:3.44E-4 ID:SGTC_2936|Compound:9038235|FD-Score:2.81|P-value:9.89E-4 ID:SGTC_3123|Compound:9126162|FD-Score:5.34|P-value:2.41E-9 ID:SGTC_3135|Compound:9127742|FD-Score:3.99|P-value:5.81E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.47|P-value:6.95E-5 ID:SGTC_110|Compound:0850-0284|FD-Score:2.94|P-value:5.98E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.85|P-value:1.20E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.22|P-value:2.60E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.48|P-value:8.75E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.27|P-value:2.07E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-2.94|P-value:7.64E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:2.92|P-value:6.50E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.74|P-value:1.00E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:-4.01|P-value:7.26E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.25|P-value:1.75E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:2.98|P-value:5.27E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.47|P-value:8.88E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.22|P-value:1.97E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.13|P-value:4.08E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:2.96|P-value:5.60E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.90|P-value:1.27E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.78|P-value:1.65E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:3.11|P-value:3.15E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.94|P-value:6.06E-11 ID:SGTC_1112|Compound:tnp00069|FD-Score:2.92|P-value:6.56E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.10|P-value:4.19E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.01|P-value:4.60E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.34|P-value:1.53E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.21|P-value:2.64E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.13|P-value:2.83E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.49|P-value:6.23E-5 ID:SGTC_2217|Compound:6934799|FD-Score:3.17|P-value:2.41E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.78|P-value:1.62E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.72|P-value:2.21E-5 ID:SGTC_2379|Compound:9035213|FD-Score:2.83|P-value:9.13E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.18|P-value:2.33E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.86|P-value:8.34E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.28|P-value:1.55E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.77|P-value:1.76E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.28|P-value:1.54E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.10|P-value:3.18E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.10|P-value:3.23E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.49|P-value:8.36E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-5.12|P-value:1.50E-8 ID:SGTC_2884|Compound:9058502|FD-Score:3.08|P-value:3.44E-4 ID:SGTC_2936|Compound:9038235|FD-Score:2.81|P-value:9.89E-4 ID:SGTC_3123|Compound:9126162|FD-Score:5.34|P-value:2.41E-9 ID:SGTC_3135|Compound:9127742|FD-Score:3.99|P-value:5.81E-6

Top fitness defect scores for YJL122W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3123 9126162 5.34 49.5 µM 2.41E-9 5 4.59E-8
2 SGTC_353 1988-1175 4.74 58.3 µM 1.00E-7 unfolded protein response 14 1.06E-6
3 SGTC_3135 9127742 3.99 49.5 µM 5.81E-6 19 3.25E-5
4 SGTC_112 phenothiazine 3.85 287.2 µM 1.20E-5 unfolded protein response 15 5.99E-5
5 SGTC_2242 6630449 3.78 61.3 µM 1.62E-5 Golgi 48 7.72E-5
6 SGTC_874 0599-0792 3.78 117.0 µM 1.65E-5 32 7.83E-5
7 SGTC_2528 xanthyletin 3.77 44.8 µM 1.76E-5 27 8.29E-5
8 SGTC_2297 7971671 3.72 152.3 µM 2.21E-5 RNA processing & uracil transport 35 1.00E-4
9 SGTC_2216 7189485 3.49 200.0 µM 6.23E-5 5 2.40E-4
10 SGTC_6 0844-0013 3.47 19.8 µM 6.95E-5 143 2.64E-4
11 SGTC_2529 gangaleoidin 3.28 93.6 µM 1.54E-4 36 5.17E-4
12 SGTC_2520 obtusaquinone 3.28 4.7 µM 1.55E-4 38 5.18E-4
13 SGTC_392 N-ethylmaleimide 3.25 8.3 µM 1.75E-4 RNA pol III & RNase P/MRP 34 5.75E-4
14 SGTC_667 1498-1044 3.22 59.0 µM 1.97E-4 RPP1 & pyrimidine depletion 47 6.36E-4
15 SGTC_2453 5731132 3.18 22.2 µM 2.33E-4 56 7.32E-4
16 SGTC_2217 6934799 3.17 96.1 µM 2.41E-4 TSC3-RPN4 19 7.53E-4
17 SGTC_1756 st041558 3.13 35.5 µM 2.83E-4 28 8.63E-4
18 SGTC_882 0843-0131 3.11 351.0 µM 3.15E-4 45 9.46E-4
19 SGTC_2607 solasodine 3.10 47.4 µM 3.18E-4 95 9.53E-4
20 SGTC_2849 9019321 3.10 13.0 µM 3.23E-4 66 9.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 9.85E-33 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.175 1.60E-24 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.171 2.17E-23 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.171 2.43E-23 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.165 5.95E-22 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.165 6.33E-22 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.164 1.34E-21 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.164 1.38E-21 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.163 1.81E-21 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.162 2.90E-21 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.159 2.22E-20 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.158 4.59E-20 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.156 1.00E-19 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.153 4.39E-19 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.153 5.79E-19 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme