YJL132W_p

Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL132W / YJL132W

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-2.97|P-value:7.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.76|P-value:4.24E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:3.11|P-value:5.79E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.14|P-value:5.20E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:2.99|P-value:9.26E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.02|P-value:8.31E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.74|P-value:4.64E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.76|P-value:4.31E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.89|P-value:2.43E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.32|P-value:2.69E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.15|P-value:5.11E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-2.96|P-value:8.41E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.89|P-value:1.87E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.85|P-value:2.85E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.12|P-value:5.65E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.08|P-value:6.60E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.61|P-value:8.21E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.40|P-value:1.91E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.01|P-value:8.35E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.57|P-value:7.46E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.08|P-value:5.27E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.15|P-value:5.05E-4 ID:SGTC_2793|Compound:7325131|FD-Score:2.96|P-value:9.97E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.28|P-value:2.45E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.39|P-value:1.60E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.21|P-value:4.05E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.97|P-value:7.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.76|P-value:4.24E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:3.11|P-value:5.79E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.14|P-value:5.20E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:2.99|P-value:9.26E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.02|P-value:8.31E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.74|P-value:4.64E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.76|P-value:4.31E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.89|P-value:2.43E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.32|P-value:2.69E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.15|P-value:5.11E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-2.96|P-value:8.41E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.89|P-value:1.87E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.85|P-value:2.85E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.12|P-value:5.65E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.08|P-value:6.60E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.61|P-value:8.21E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.40|P-value:1.91E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.01|P-value:8.35E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.57|P-value:7.46E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.08|P-value:5.27E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.15|P-value:5.05E-4 ID:SGTC_2793|Compound:7325131|FD-Score:2.96|P-value:9.97E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.28|P-value:2.45E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.39|P-value:1.60E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.21|P-value:4.05E-4

Top fitness defect scores for YJL132W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1191 1487-1166 3.89 10.6 µM 2.43E-5 azole & statin 34 5.08E-5
2 SGTC_1860 st056228 3.85 74.6 µM 2.85E-5 26 5.87E-5
3 SGTC_58 0957-0393 3.76 9.0 µM 4.24E-5 cell wall 392 8.44E-5
4 SGTC_669 0108-0021 3.76 26.2 µM 4.31E-5 fatty acid desaturase (OLE1) 90 8.57E-5
5 SGTC_536 3852-0578 3.74 10.6 µM 4.64E-5 31 9.17E-5
6 SGTC_2085 5307070 3.61 144.1 µM 8.21E-5 superoxide 38 1.54E-4
7 SGTC_2343 7990716 3.40 14.8 µM 1.91E-4 36 3.34E-4
8 SGTC_2614 arthonioic acid 3.33 13.4 µM 2.53E-4 40 4.32E-4
9 SGTC_1283 0922-0125 3.32 16.4 µM 2.69E-4 44 4.57E-4
10 SGTC_2957 9076800 3.21 11.5 µM 4.05E-4 43 6.65E-4
11 SGTC_2770 toltrazuril 3.15 17.5 µM 5.05E-4 62 8.13E-4
12 SGTC_1333 1482-0047 3.15 286.0 µM 5.11E-4 47 8.22E-4
13 SGTC_220 paclitaxel 3.14 373.4 µM 5.20E-4 23 8.35E-4
14 SGTC_1936 st074407 3.12 74.3 µM 5.65E-4 DNA damage response 89 9.02E-4
15 SGTC_82 0054-0107 3.11 293.8 µM 5.79E-4 25 9.21E-4
16 SGTC_2002 4023503 3.08 131.0 µM 6.60E-4 mitochondrial processes 79 0.00104
17 SGTC_752 1896-0090 3.07 130.0 µM 6.88E-4 TSC3-RPN4 48 0.00108
18 SGTC_534 k292-0788 3.02 63.4 µM 8.31E-4 mitochondrial processes 64 0.00128
19 SGTC_2572 astragaloside iv 3.01 100.0 µM 8.35E-4 77 0.00129
20 SGTC_363 0455-0021 2.99 3.1 µM 9.26E-4 azole & statin 133 0.00142

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.252 8.07E-50 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.197 1.30E-30 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.172 7.70E-24 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.170 4.75E-23 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.158 2.81E-20 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.154 2.57E-19 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.150 2.89E-18 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.146 2.07E-17 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.143 8.47E-17 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.141 2.53E-16 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.138 1.03E-15 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.137 1.63E-15 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.136 2.69E-15 YDL063C SYO1 hom Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.136 2.98E-15 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.135 5.20E-15 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources