YJL135W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL135W / YJL135W

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-2.99|P-value:3.92E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:2.82|P-value:8.54E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.10|P-value:2.55E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:3.11|P-value:2.76E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.45|P-value:6.08E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.00|P-value:4.27E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:2.85|P-value:7.77E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:2.93|P-value:5.71E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.49|P-value:5.12E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:14.30|P-value:1.42E-57 ID:SGTC_470|Compound:aa-861|FD-Score:4.14|P-value:1.99E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.04|P-value:3.16E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-2.89|P-value:5.85E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:2.92|P-value:5.94E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.91|P-value:6.74E-6 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.01|P-value:3.56E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.68|P-value:1.80E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.34|P-value:6.80E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:4.06|P-value:3.13E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.21|P-value:1.55E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.01|P-value:4.04E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:2.81|P-value:8.92E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.06|P-value:3.27E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.75|P-value:1.24E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.06|P-value:3.07E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:2.90|P-value:6.43E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.92|P-value:5.27E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.17|P-value:1.41E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:2.97|P-value:4.86E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.14|P-value:2.00E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:2.92|P-value:5.92E-4 ID:SGTC_1708|Compound:st033234|FD-Score:4.12|P-value:2.27E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-2.77|P-value:9.22E-4 ID:SGTC_1855|Compound:st056195|FD-Score:2.82|P-value:8.64E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.10|P-value:2.80E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.48|P-value:4.60E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-3.11|P-value:2.38E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.93|P-value:6.13E-6 ID:SGTC_2084|Compound:5306078|FD-Score:-3.33|P-value:9.03E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.29|P-value:1.28E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.01|P-value:3.66E-4 ID:SGTC_2297|Compound:7971671|FD-Score:2.95|P-value:5.14E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.97|P-value:4.77E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-2.87|P-value:6.30E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.27|P-value:8.27E-7 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-5.14|P-value:4.20E-9 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.72|P-value:5.84E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.12|P-value:2.31E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.19|P-value:3.64E-9 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.36|P-value:9.37E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:2.90|P-value:6.22E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.88|P-value:6.60E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.31|P-value:1.00E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.99|P-value:3.92E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:2.82|P-value:8.54E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.10|P-value:2.55E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:3.11|P-value:2.76E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.45|P-value:6.08E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.00|P-value:4.27E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:2.85|P-value:7.77E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:2.93|P-value:5.71E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.49|P-value:5.12E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:14.30|P-value:1.42E-57 ID:SGTC_470|Compound:aa-861|FD-Score:4.14|P-value:1.99E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.04|P-value:3.16E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-2.89|P-value:5.85E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:2.92|P-value:5.94E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.91|P-value:6.74E-6 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.01|P-value:3.56E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.68|P-value:1.80E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.34|P-value:6.80E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:4.06|P-value:3.13E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.21|P-value:1.55E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.01|P-value:4.04E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:2.81|P-value:8.92E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.06|P-value:3.27E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.75|P-value:1.24E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.06|P-value:3.07E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:2.90|P-value:6.43E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.92|P-value:5.27E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.17|P-value:1.41E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:2.97|P-value:4.86E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.14|P-value:2.00E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:2.92|P-value:5.92E-4 ID:SGTC_1708|Compound:st033234|FD-Score:4.12|P-value:2.27E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-2.77|P-value:9.22E-4 ID:SGTC_1855|Compound:st056195|FD-Score:2.82|P-value:8.64E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.10|P-value:2.80E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.48|P-value:4.60E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-3.11|P-value:2.38E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.93|P-value:6.13E-6 ID:SGTC_2084|Compound:5306078|FD-Score:-3.33|P-value:9.03E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.29|P-value:1.28E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.01|P-value:3.66E-4 ID:SGTC_2297|Compound:7971671|FD-Score:2.95|P-value:5.14E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.97|P-value:4.77E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-2.87|P-value:6.30E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.27|P-value:8.27E-7 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-5.14|P-value:4.20E-9 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.72|P-value:5.84E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.12|P-value:2.31E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.19|P-value:3.64E-9 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.36|P-value:9.37E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:2.90|P-value:6.22E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.88|P-value:6.60E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.31|P-value:1.00E-4

Top fitness defect scores for YJL135W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_457 grayanotoxin iii 14.30 135.0 µM 1.42E-57 2 1.40E-46
2 SGTC_2618 avocadyne 5.19 43.4 µM 3.64E-9 24 1.05E-7
3 SGTC_916 4466-0038 4.34 42.0 nM 6.80E-7 cell wall 54 7.22E-6
4 SGTC_470 aa-861 4.14 153.0 µM 1.99E-6 sphingolipid biosynthesis & PDR1 48 1.72E-5
5 SGTC_1391 3442-0225 4.14 151.0 µM 2.00E-6 12 1.73E-5
6 SGTC_1708 st033234 4.12 31.8 µM 2.27E-6 12 1.92E-5
7 SGTC_179 1273-0063 4.10 6.8 µM 2.55E-6 19 2.11E-5
8 SGTC_1131 3454-3128 4.06 32.3 µM 3.07E-6 41 2.45E-5
9 SGTC_955 1216-0110 4.06 33.0 µM 3.13E-6 sphingolipid biosynthesis & PDR1 59 2.49E-5
10 SGTC_2049 5262831 3.93 67.2 µM 6.13E-6 28 4.30E-5
11 SGTC_669 0108-0021 3.91 26.2 µM 6.74E-6 fatty acid desaturase (OLE1) 82 4.64E-5
12 SGTC_450 aminopyrene 3.49 156.0 nM 5.12E-5 52 2.41E-4
13 SGTC_181 1447-1644 3.45 8.1 µM 6.08E-5 endomembrane recycling 49 2.77E-4
14 SGTC_2629 bisabolol 3.36 100.0 µM 9.37E-5 44 3.94E-4
15 SGTC_2119 5528445 3.29 120.6 µM 1.28E-4 43 5.09E-4
16 SGTC_180 1486-1293 3.11 102.8 µM 2.76E-4 78 9.49E-4
17 SGTC_1939 st074455 3.10 53.6 µM 2.80E-4 66 9.61E-4
18 SGTC_1032 k061-1018 3.06 98.7 µM 3.27E-4 63 0.00109
19 SGTC_996 3970-0799 3.01 1.8 µM 4.04E-4 153 0.00130
20 SGTC_266 formosanin C 3.00 406.0 nM 4.27E-4 sphingolipid biosynthesis & PDR1 117 0.00136

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.290 3.60E-66 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.274 1.19E-58 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.253 2.42E-50 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.246 1.25E-47 YDR297W SUR2 hom Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
0.217 3.31E-37 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.186 1.54E-27 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.184 5.25E-27 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.178 3.01E-25 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.178 3.72E-25 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.175 1.29E-24 YDR099W BMH2 hom 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.169 8.18E-23 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.164 9.79E-22 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.156 9.64E-20 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.152 8.28E-19 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.152 9.42E-19 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions