HIPHOP chemogenomics database
YJL135W_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJL135W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.290 | 3.60E-66 | YJL134W | LCB3 | hom | Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication |
| 0.274 | 1.19E-58 | YOR047C | STD1 | hom | Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] |
| 0.253 | 2.42E-50 | YNR044W | AGA1 | hom | Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds |
| 0.246 | 1.25E-47 | YDR297W | SUR2 | hom | Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis |
| 0.217 | 3.31E-37 | YGR058W | PEF1 | hom | Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly |
| 0.186 | 1.54E-27 | YDR042C_p | YDR042C_p | hom | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant |
| 0.184 | 5.25E-27 | YOR170W_d | YOR170W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 |
| 0.178 | 3.01E-25 | YOR171C | LCB4 | hom | Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes |
| 0.178 | 3.72E-25 | YER071C_p | TDA2_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele |
| 0.175 | 1.29E-24 | YDR099W | BMH2 | hom | 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress |
| 0.169 | 8.18E-23 | YGL081W_p | YGL081W_p | hom | Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis |
| 0.164 | 9.79E-22 | YBL086C_p | YBL086C_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 0.156 | 9.64E-20 | YOR061W | CKA2 | hom | Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching |
| 0.152 | 8.28E-19 | YDR252W | BTT1 | hom | Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 |
| 0.152 | 9.42E-19 | YFL049W | SWP82 | hom | Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions |