YJL136C / RPS21B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL136C / RPS21B

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:7.38|P-value:1.25E-13 ID:SGTC_84|Compound:0443-0269|FD-Score:3.87|P-value:6.55E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.64|P-value:1.34E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.86|P-value:6.78E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.37|P-value:4.30E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.23|P-value:7.04E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.82|P-value:8.12E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.87|P-value:5.32E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.95|P-value:3.85E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.47|P-value:2.53E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.04|P-value:3.29E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.90|P-value:5.89E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:6.71|P-value:1.41E-11 ID:SGTC_791|Compound:1348-1292|FD-Score:4.02|P-value:3.58E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.25|P-value:2.91E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:3.67|P-value:1.45E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.22|P-value:7.39E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.27|P-value:6.17E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.11|P-value:2.42E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:4.65|P-value:2.09E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:5.05|P-value:2.87E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.86|P-value:7.58E-7 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.42|P-value:3.69E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.31|P-value:5.40E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.17|P-value:8.77E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.61|P-value:1.80E-4 ID:SGTC_1688|Compound:st021091|FD-Score:-3.80|P-value:7.06E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.52|P-value:2.09E-4 ID:SGTC_1781|Compound:st038725|FD-Score:22.80|P-value:7.99E-114 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.80|P-value:6.98E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.90|P-value:4.64E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.35|P-value:4.64E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.40|P-value:3.26E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.20|P-value:6.60E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.17|P-value:7.44E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.97|P-value:3.45E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-3.84|P-value:6.05E-5 ID:SGTC_1935|Compound:st074532|FD-Score:5.12|P-value:1.97E-7 ID:SGTC_1948|Compound:st076329|FD-Score:4.14|P-value:2.09E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.45|P-value:3.25E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.52|P-value:2.57E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.17|P-value:8.70E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.97|P-value:4.41E-5 ID:SGTC_2176|Compound:5809774|FD-Score:3.27|P-value:6.29E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.55|P-value:2.25E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.41|P-value:6.42E-6 ID:SGTC_2421|Compound:5690543|FD-Score:3.96|P-value:4.54E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.13|P-value:1.80E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.33|P-value:6.34E-8 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.68|P-value:1.38E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.47|P-value:3.07E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.29|P-value:4.80E-4 ID:SGTC_2859|Compound:9028643|FD-Score:4.48|P-value:4.62E-6 ID:SGTC_2869|Compound:9037858|FD-Score:-3.13|P-value:8.50E-4 ID:SGTC_2902|Compound:5787006|FD-Score:5.02|P-value:3.37E-7 ID:SGTC_2906|Compound:7926292|FD-Score:3.80|P-value:8.73E-5 ID:SGTC_2911|Compound:7942208|FD-Score:-4.41|P-value:4.99E-6 ID:SGTC_2915|Compound:7971052|FD-Score:6.91|P-value:3.74E-12 ID:SGTC_2942|Compound:9052777|FD-Score:-4.15|P-value:1.65E-5 ID:SGTC_2946|Compound:9065502|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.25|P-value:5.66E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.43|P-value:3.54E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.78|P-value:1.13E-6 ID:SGTC_3076|Compound:9116187|FD-Score:3.44|P-value:3.39E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.29|P-value:1.11E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.87|P-value:6.48E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:7.38|P-value:1.25E-13 ID:SGTC_84|Compound:0443-0269|FD-Score:3.87|P-value:6.55E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.64|P-value:1.34E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.86|P-value:6.78E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.37|P-value:4.30E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.23|P-value:7.04E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.82|P-value:8.12E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.87|P-value:5.32E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.95|P-value:3.85E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.47|P-value:2.53E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.04|P-value:3.29E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.90|P-value:5.89E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:6.71|P-value:1.41E-11 ID:SGTC_791|Compound:1348-1292|FD-Score:4.02|P-value:3.58E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.25|P-value:2.91E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:3.67|P-value:1.45E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.22|P-value:7.39E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.27|P-value:6.17E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.11|P-value:2.42E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:4.65|P-value:2.09E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:5.05|P-value:2.87E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.86|P-value:7.58E-7 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.42|P-value:3.69E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.31|P-value:5.40E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.17|P-value:8.77E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.61|P-value:1.80E-4 ID:SGTC_1688|Compound:st021091|FD-Score:-3.80|P-value:7.06E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.52|P-value:2.09E-4 ID:SGTC_1781|Compound:st038725|FD-Score:22.80|P-value:7.99E-114 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.80|P-value:6.98E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.90|P-value:4.64E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.35|P-value:4.64E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.40|P-value:3.26E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.20|P-value:6.60E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.17|P-value:7.44E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.97|P-value:3.45E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-3.84|P-value:6.05E-5 ID:SGTC_1935|Compound:st074532|FD-Score:5.12|P-value:1.97E-7 ID:SGTC_1948|Compound:st076329|FD-Score:4.14|P-value:2.09E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.45|P-value:3.25E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.52|P-value:2.57E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.17|P-value:8.70E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.97|P-value:4.41E-5 ID:SGTC_2176|Compound:5809774|FD-Score:3.27|P-value:6.29E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.55|P-value:2.25E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.41|P-value:6.42E-6 ID:SGTC_2421|Compound:5690543|FD-Score:3.96|P-value:4.54E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.13|P-value:1.80E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.33|P-value:6.34E-8 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.68|P-value:1.38E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.47|P-value:3.07E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.29|P-value:4.80E-4 ID:SGTC_2859|Compound:9028643|FD-Score:4.48|P-value:4.62E-6 ID:SGTC_2869|Compound:9037858|FD-Score:-3.13|P-value:8.50E-4 ID:SGTC_2902|Compound:5787006|FD-Score:5.02|P-value:3.37E-7 ID:SGTC_2906|Compound:7926292|FD-Score:3.80|P-value:8.73E-5 ID:SGTC_2911|Compound:7942208|FD-Score:-4.41|P-value:4.99E-6 ID:SGTC_2915|Compound:7971052|FD-Score:6.91|P-value:3.74E-12 ID:SGTC_2942|Compound:9052777|FD-Score:-4.15|P-value:1.65E-5 ID:SGTC_2946|Compound:9065502|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.25|P-value:5.66E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.43|P-value:3.54E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.78|P-value:1.13E-6 ID:SGTC_3076|Compound:9116187|FD-Score:3.44|P-value:3.39E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.29|P-value:1.11E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.87|P-value:6.48E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.74|P-value:1.11E-4

Top fitness defect scores for YJL136C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1781 st038725 22.80 66.3 µM 7.99E-114 NEO1 3 3.54E-115
2 SGTC_33 0986-0033 7.38 35.8 µM 1.25E-13 calcium & mitochondrial duress 4 7.91E-14
3 SGTC_2915 7971052 6.91 15.2 µM 3.74E-12 1 2.47E-12
4 SGTC_625 k213-0058 6.71 121.0 µM 1.41E-11 translation 25 9.47E-12
5 SGTC_800 3448-7362 6.25 155.0 µM 2.91E-10 translation 41 2.04E-10
6 SGTC_2688 kanamycin b 5.33 96.7 µM 6.34E-8 calcium & mitochondrial duress 217 4.78E-8
7 SGTC_1935 st074532 5.12 41.6 µM 1.97E-7 8 1.51E-7
8 SGTC_1078 idebenone 5.05 36.1 µM 2.87E-7 Golgi 18 2.21E-7
9 SGTC_2902 5787006 5.02 60.5 µM 3.37E-7 Golgi 12 2.60E-7
10 SGTC_1155 4088-0394 4.86 48.2 µM 7.58E-7 9 5.92E-7
11 SGTC_2999 9069765 4.78 71.4 µM 1.13E-6 amide catabolism 10 8.85E-7
12 SGTC_968 1309-0633 4.65 340.0 µM 2.09E-6 7 1.66E-6
13 SGTC_2859 9028643 4.48 45.5 µM 4.62E-6 7 3.71E-6
14 SGTC_2325 6158266 4.41 200.0 µM 6.42E-6 16 5.18E-6
15 SGTC_3235 9132602 4.29 49.5 µM 1.11E-5 16 9.02E-6
16 SGTC_1948 st076329 4.14 66.6 µM 2.09E-5 22 1.71E-5
17 SGTC_940 3232-1287 4.11 54.8 µM 2.42E-5 NEO1 30 1.99E-5
18 SGTC_582 0987-0078 4.04 156.0 µM 3.29E-5 calcium & mitochondrial duress 65 2.72E-5
19 SGTC_791 1348-1292 4.02 225.0 µM 3.58E-5 35 2.96E-5
20 SGTC_2084 5306078 3.97 60.6 µM 4.41E-5 19 3.66E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.341 7.25E-92 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.270 2.94E-57 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.256 2.07E-51 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.234 4.48E-43 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.230 1.27E-41 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.230 1.84E-41 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.229 3.44E-41 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.213 8.48E-36 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
0.212 2.33E-35 YOL121C RPS19A hom Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication
0.210 7.94E-35 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.207 8.02E-34 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.201 5.08E-32 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.193 1.66E-29 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.192 2.84E-29 YDR174W HMO1 hom Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
0.191 8.65E-29 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC