YJL136W-A_p

Putative protein of unknown function; identified by SAGE

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL136W-A / YJL136W-A

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.73|P-value:2.82E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.78|P-value:7.15E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.60|P-value:1.85E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.26|P-value:5.20E-7 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.13|P-value:1.61E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.98|P-value:2.52E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-2.89|P-value:4.54E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.65|P-value:1.39E-5 ID:SGTC_406|Compound:estrone|FD-Score:2.95|P-value:3.50E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.31|P-value:7.11E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:-2.70|P-value:9.71E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:2.77|P-value:7.28E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.74|P-value:8.32E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.26|P-value:9.10E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.14|P-value:1.57E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.83|P-value:5.71E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:2.91|P-value:4.27E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.16|P-value:1.43E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-2.77|P-value:7.34E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-2.72|P-value:9.00E-4 ID:SGTC_1974|Compound:st069448|FD-Score:2.71|P-value:9.33E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-2.74|P-value:8.46E-4 ID:SGTC_2108|Compound:5365811|FD-Score:2.72|P-value:9.07E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-2.71|P-value:9.31E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.11|P-value:1.85E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.31|P-value:7.43E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-2.84|P-value:5.69E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.08|P-value:2.06E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.73|P-value:2.82E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.78|P-value:7.15E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.60|P-value:1.85E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.26|P-value:5.20E-7 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.13|P-value:1.61E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.98|P-value:2.52E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-2.89|P-value:4.54E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.65|P-value:1.39E-5 ID:SGTC_406|Compound:estrone|FD-Score:2.95|P-value:3.50E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.31|P-value:7.11E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:-2.70|P-value:9.71E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:2.77|P-value:7.28E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.74|P-value:8.32E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.26|P-value:9.10E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.14|P-value:1.57E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.83|P-value:5.71E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:2.91|P-value:4.27E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.16|P-value:1.43E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-2.77|P-value:7.34E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-2.72|P-value:9.00E-4 ID:SGTC_1974|Compound:st069448|FD-Score:2.71|P-value:9.33E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-2.74|P-value:8.46E-4 ID:SGTC_2108|Compound:5365811|FD-Score:2.72|P-value:9.07E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-2.71|P-value:9.31E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.11|P-value:1.85E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.31|P-value:7.43E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-2.84|P-value:5.69E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.08|P-value:2.06E-4

Top fitness defect scores for YJL136W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 4.73 35.0 µM 2.82E-8 calcium & mitochondrial duress 61 1.11E-6
2 SGTC_236 1509-0011 4.26 5.3 µM 5.20E-7 365 1.04E-5
3 SGTC_261 5-fluorouridine 3.98 15.4 µM 2.52E-6 exosome 9 3.50E-5
4 SGTC_321 4534-3890 3.65 65.3 µM 1.39E-5 RPP1 & pyrimidine depletion 8 1.30E-4
5 SGTC_622 1348-1566 3.31 26.3 µM 7.11E-5 38 4.58E-4
6 SGTC_2809 7964133 3.31 13.0 µM 7.43E-5 60S ribosome export 73 4.74E-4
7 SGTC_1119 parthenolide 3.26 318.5 nM 9.10E-5 TSC3-RPN4 78 5.54E-4
8 SGTC_1626 st003712 3.16 1.8 µM 1.43E-4 52 7.85E-4
9 SGTC_1209 2323-2347 3.14 50.3 µM 1.57E-4 39 8.44E-4
10 SGTC_250 brefeldin a 3.13 552.2 µM 1.61E-4 PDR1 40 8.64E-4
11 SGTC_3203 9113543 3.08 49.5 µM 2.06E-4 78 0.00104
12 SGTC_406 estrone 2.95 100.0 µM 3.50E-4 43 0.00157
13 SGTC_1351 1496-0003 2.91 46.5 µM 4.27E-4 63 0.00183
14 SGTC_1211 1056-0033 2.83 32.3 µM 5.71E-4 48 0.00230
15 SGTC_969 1313-0238 2.77 134.0 µM 7.28E-4 mitochondrial processes 94 0.00277
16 SGTC_1088 bifonazole 2.74 369.0 nM 8.32E-4 63 0.00308
17 SGTC_2108 5365811 2.72 200.0 µM 9.07E-4 83 0.00329
18 SGTC_1974 st069448 2.71 26.9 µM 9.33E-4 76 0.00336
19 SGTC_2879 9041815 2.69 71.4 µM 0.00101 24 0.00358
20 SGTC_334 1502-1024 2.68 68.5 µM 0.00105 82 0.00367

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.290 5.69E-66 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.258 5.80E-52 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.257 2.26E-51 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.250 1.26E-48 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.245 9.88E-47 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.241 2.65E-45 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.240 5.82E-45 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.233 2.66E-42 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.232 3.25E-42 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.231 8.79E-42 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.228 1.21E-40 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.222 1.76E-38 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.215 1.98E-36 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.211 4.68E-35 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.210 8.88E-35 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases