HIPHOP chemogenomics database

YJL136W-A_p

Putative protein of unknown function; identified by SAGE

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL136W-A / YJL136W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YJL136W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_65	0798-0905	4.73	35.0 µM	2.82E-8	calcium & mitochondrial duress	61	1.11E-6
2	SGTC_236	1509-0011	4.26	5.3 µM	5.20E-7		365	1.04E-5
3	SGTC_261	5-fluorouridine	3.98	15.4 µM	2.52E-6	exosome	9	3.50E-5
4	SGTC_321	4534-3890	3.65	65.3 µM	1.39E-5	RPP1 & pyrimidine depletion	8	1.30E-4
5	SGTC_622	1348-1566	3.31	26.3 µM	7.11E-5		38	4.58E-4
6	SGTC_2809	7964133	3.31	13.0 µM	7.43E-5	60S ribosome export	73	4.74E-4
7	SGTC_1119	parthenolide	3.26	318.5 nM	9.10E-5	TSC3-RPN4	78	5.54E-4
8	SGTC_1626	st003712	3.16	1.8 µM	1.43E-4		52	7.85E-4
9	SGTC_1209	2323-2347	3.14	50.3 µM	1.57E-4		39	8.44E-4
10	SGTC_250	brefeldin a	3.13	552.2 µM	1.61E-4	PDR1	40	8.64E-4
11	SGTC_3203	9113543	3.08	49.5 µM	2.06E-4		78	0.00104
12	SGTC_406	estrone	2.95	100.0 µM	3.50E-4		43	0.00157
13	SGTC_1351	1496-0003	2.91	46.5 µM	4.27E-4		63	0.00183
14	SGTC_1211	1056-0033	2.83	32.3 µM	5.71E-4		48	0.00230
15	SGTC_969	1313-0238	2.77	134.0 µM	7.28E-4	mitochondrial processes	94	0.00277
16	SGTC_1088	bifonazole	2.74	369.0 nM	8.32E-4		63	0.00308
17	SGTC_2108	5365811	2.72	200.0 µM	9.07E-4		83	0.00329
18	SGTC_1974	st069448	2.71	26.9 µM	9.33E-4		76	0.00336
19	SGTC_2879	9041815	2.69	71.4 µM	0.00101		24	0.00358
20	SGTC_334	1502-1024	2.68	68.5 µM	0.00105		82	0.00367

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.290	5.69E-66	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.258	5.80E-52	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.257	2.26E-51	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.250	1.26E-48	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.245	9.88E-47	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.241	2.65E-45	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.240	5.82E-45	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.233	2.66E-42	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.232	3.25E-42	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.231	8.79E-42	YDR148C	KGD2	hom	Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.228	1.21E-40	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.222	1.76E-38	YMR286W	MRPL33	hom	Mitochondrial ribosomal protein of the large subunit
0.215	1.98E-36	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.211	4.68E-35	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.210	8.88E-35	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases