YJL142C_d / IRC9

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL142C / IRC9

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:2.85|P-value:9.48E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.98|P-value:7.71E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:3.04|P-value:4.59E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.26|P-value:1.93E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-2.91|P-value:9.19E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.99|P-value:5.74E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.43|P-value:9.39E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.65|P-value:3.67E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.02|P-value:5.12E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.39|P-value:1.11E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.00|P-value:5.50E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.94|P-value:6.79E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.16|P-value:3.60E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.00|P-value:9.04E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.02|P-value:5.10E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.03|P-value:5.88E-6 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.18|P-value:2.68E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.26|P-value:1.92E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:2.88|P-value:8.59E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.33|P-value:1.47E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.23|P-value:2.21E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-3.45|P-value:1.11E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.66|P-value:4.44E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.20|P-value:2.44E-4 ID:SGTC_2342|Compound:7990637|FD-Score:2.90|P-value:7.86E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.94|P-value:9.26E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.31|P-value:2.00E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.03|P-value:5.95E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.42|P-value:1.24E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-5.35|P-value:4.54E-9 ID:SGTC_2537|Compound:larixol|FD-Score:-4.33|P-value:1.69E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.18|P-value:3.30E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.73|P-value:2.50E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.28|P-value:1.76E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.67|P-value:4.27E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.00|P-value:5.48E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.37|P-value:1.22E-4 ID:SGTC_2947|Compound:9072639|FD-Score:9.21|P-value:1.04E-23 ID:SGTC_2950|Compound:9072895|FD-Score:3.20|P-value:2.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:2.88|P-value:8.47E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.78|P-value:2.00E-5 ID:SGTC_3019|Compound:9081971|FD-Score:4.86|P-value:6.48E-8 ID:SGTC_3027|Compound:9089541|FD-Score:4.66|P-value:2.12E-7 ID:SGTC_3068|Compound:9116768|FD-Score:-3.62|P-value:5.34E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.29|P-value:1.71E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.27|P-value:1.90E-4 ID:SGTC_3259|Compound:9138485|FD-Score:2.86|P-value:9.15E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.25|P-value:2.51E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-2.95|P-value:7.93E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:2.85|P-value:9.48E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.98|P-value:7.71E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:3.04|P-value:4.59E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.26|P-value:1.93E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-2.91|P-value:9.19E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.99|P-value:5.74E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.43|P-value:9.39E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.65|P-value:3.67E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.02|P-value:5.12E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.39|P-value:1.11E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.00|P-value:5.50E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.94|P-value:6.79E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.16|P-value:3.60E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.00|P-value:9.04E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.02|P-value:5.10E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.03|P-value:5.88E-6 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.18|P-value:2.68E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.26|P-value:1.92E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:2.88|P-value:8.59E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.33|P-value:1.47E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.23|P-value:2.21E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-3.45|P-value:1.11E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.66|P-value:4.44E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.20|P-value:2.44E-4 ID:SGTC_2342|Compound:7990637|FD-Score:2.90|P-value:7.86E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.94|P-value:9.26E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.31|P-value:2.00E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.03|P-value:5.95E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.42|P-value:1.24E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-5.35|P-value:4.54E-9 ID:SGTC_2537|Compound:larixol|FD-Score:-4.33|P-value:1.69E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.18|P-value:3.30E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.73|P-value:2.50E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.28|P-value:1.76E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.67|P-value:4.27E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.00|P-value:5.48E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.37|P-value:1.22E-4 ID:SGTC_2947|Compound:9072639|FD-Score:9.21|P-value:1.04E-23 ID:SGTC_2950|Compound:9072895|FD-Score:3.20|P-value:2.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:2.88|P-value:8.47E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.78|P-value:2.00E-5 ID:SGTC_3019|Compound:9081971|FD-Score:4.86|P-value:6.48E-8 ID:SGTC_3027|Compound:9089541|FD-Score:4.66|P-value:2.12E-7 ID:SGTC_3068|Compound:9116768|FD-Score:-3.62|P-value:5.34E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.29|P-value:1.71E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.27|P-value:1.90E-4 ID:SGTC_3259|Compound:9138485|FD-Score:2.86|P-value:9.15E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.25|P-value:2.51E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-2.95|P-value:7.93E-4

Top fitness defect scores for YJL142C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2947 9072639 9.21 7.7 µM 1.04E-23 tubulin folding & SWR complex 3 1.65E-20
2 SGTC_3019 9081971 4.86 49.5 µM 6.48E-8 8 5.75E-7
3 SGTC_3027 9089541 4.66 49.5 µM 2.12E-7 fatty acid desaturase (OLE1) 11 1.59E-6
4 SGTC_1192 1488-0095 4.03 21.4 µM 5.88E-6 14 2.76E-5
5 SGTC_135 0933-0004 3.98 26.4 µM 7.71E-6 60S ribosome export 24 3.48E-5
6 SGTC_2387 9077560 3.94 195.1 µM 9.26E-6 18 4.07E-5
7 SGTC_3007 9078383 3.78 71.4 µM 2.00E-5 20 7.91E-5
8 SGTC_2600 tangeritin 3.73 88.0 µM 2.50E-5 40 9.57E-5
9 SGTC_610 4215-0184 3.65 155.0 µM 3.67E-5 exosome 20 1.33E-4
10 SGTC_602 3130-1533 3.43 38.1 µM 9.39E-5 35 2.98E-4
11 SGTC_644 1498-1197 3.39 63.3 µM 1.11E-4 47 3.44E-4
12 SGTC_2929 9013348 3.37 24.6 µM 1.22E-4 44 3.75E-4
13 SGTC_1585 2',4'-dihydroxychalcone 3.33 10.4 µM 1.47E-4 56 4.38E-4
14 SGTC_3099 9120367 3.29 49.5 µM 1.71E-4 38 4.99E-4
15 SGTC_2633 5,7-dihydroxyisoflavone 3.28 100.0 µM 1.76E-4 56 5.11E-4
16 SGTC_3223 9129970 3.27 49.5 µM 1.90E-4 42 5.46E-4
17 SGTC_1463 k081-0032 3.26 34.1 µM 1.92E-4 16 5.51E-4
18 SGTC_264 promethazine 3.26 12.5 mM 1.93E-4 DNA intercalators 99 5.54E-4
19 SGTC_1748 st037455 3.23 53.6 µM 2.21E-4 64 6.22E-4
20 SGTC_2324 6149169 3.20 200.0 µM 2.44E-4 40 6.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.75E-16 YEL055C POL5 het DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
0.094 5.16E-8 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
0.091 1.38E-7 YNL201C PSY2 hom Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
0.091 1.52E-7 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.087 4.76E-7 YKL053C-A MDM35 hom Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.086 5.97E-7 YDR030C RAD28 hom Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
0.085 7.58E-7 YBR182C SMP1 hom Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication
0.085 7.77E-7 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
0.085 8.21E-7 YOR354C MSC6 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.082 2.14E-6 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.081 2.38E-6 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.080 3.90E-6 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.077 7.85E-6 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.076 1.00E-5 YGR153W_p YGR153W_p hom Putative protein of unknown function
0.076 1.05E-5 YMR226C YMR226C hom NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments