YJL144W

Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL144W / YJL144W

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.07|P-value:6.25E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.26|P-value:3.03E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.55|P-value:9.68E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.01|P-value:7.84E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.04|P-value:7.12E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.07|P-value:6.25E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.99|P-value:1.37E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.38|P-value:1.96E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.23|P-value:4.52E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:4.15|P-value:6.38E-6 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.21|P-value:4.93E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.70|P-value:5.18E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.17|P-value:4.24E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.03|P-value:7.26E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.89|P-value:2.20E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-3.07|P-value:6.24E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.73|P-value:4.51E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.11|P-value:5.47E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.00|P-value:8.11E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.04|P-value:1.08E-5 ID:SGTC_2031|Compound:5180455|FD-Score:-2.94|P-value:9.79E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.93|P-value:1.82E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.41|P-value:1.67E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.26|P-value:3.83E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-2.99|P-value:8.18E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.15|P-value:4.76E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.01|P-value:7.80E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-9.75|P-value:5.70E-25 ID:SGTC_2448|Compound:5185112|FD-Score:-3.50|P-value:1.14E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.18|P-value:4.21E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:4.37|P-value:2.16E-6 ID:SGTC_2678|Compound:equilin|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_2805|Compound:7950783|FD-Score:5.73|P-value:8.89E-10 ID:SGTC_2993|Compound:9054257|FD-Score:-3.44|P-value:1.47E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.09|P-value:5.80E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.15|P-value:4.66E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.03|P-value:7.33E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-3.12|P-value:5.11E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.07|P-value:6.25E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.26|P-value:3.03E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.55|P-value:9.68E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.01|P-value:7.84E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.04|P-value:7.12E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.07|P-value:6.25E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.99|P-value:1.37E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.38|P-value:1.96E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.23|P-value:4.52E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:4.15|P-value:6.38E-6 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.21|P-value:4.93E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.70|P-value:5.18E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.17|P-value:4.24E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.03|P-value:7.26E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.89|P-value:2.20E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-3.07|P-value:6.24E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.73|P-value:4.51E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.11|P-value:5.47E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.00|P-value:8.11E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.04|P-value:1.08E-5 ID:SGTC_2031|Compound:5180455|FD-Score:-2.94|P-value:9.79E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.93|P-value:1.82E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.41|P-value:1.67E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.26|P-value:3.83E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-2.99|P-value:8.18E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.15|P-value:4.76E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.01|P-value:7.80E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-9.75|P-value:5.70E-25 ID:SGTC_2448|Compound:5185112|FD-Score:-3.50|P-value:1.14E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.18|P-value:4.21E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:4.37|P-value:2.16E-6 ID:SGTC_2678|Compound:equilin|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_2805|Compound:7950783|FD-Score:5.73|P-value:8.89E-10 ID:SGTC_2993|Compound:9054257|FD-Score:-3.44|P-value:1.47E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.09|P-value:5.80E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.15|P-value:4.66E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.03|P-value:7.33E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-3.12|P-value:5.11E-4

Top fitness defect scores for YJL144W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2805 7950783 5.73 58.4 µM 8.89E-10 4 5.10E-9
2 SGTC_2669 eugenol 4.37 100.0 µM 2.16E-6 7 6.09E-6
3 SGTC_2288 7946289 4.26 167.3 µM 3.83E-6 20 1.02E-5
4 SGTC_658 3253-0951 4.23 102.0 µM 4.52E-6 calcium & mitochondrial duress 52 1.19E-5
5 SGTC_1096 rimcazole 4.21 32.2 µM 4.93E-6 4 1.29E-5
6 SGTC_936 3005-4620 4.15 401.0 µM 6.38E-6 16 1.63E-5
7 SGTC_1942 st076330 4.04 65.2 µM 1.08E-5 26 2.64E-5
8 SGTC_580 1123-0028 3.99 41.0 µM 1.37E-5 DNA damage response 35 3.27E-5
9 SGTC_1395 3486-0190 3.89 4.3 µM 2.20E-5 11 5.02E-5
10 SGTC_1825 st052143 3.73 62.6 µM 4.51E-5 19 9.66E-5
11 SGTC_1106 tegaserod maleate 3.70 11.7 µM 5.18E-5 30 1.10E-4
12 SGTC_256 clotrimazole 3.55 625.0 nM 9.68E-5 ergosterol depletion effects on membrane 38 1.94E-4
13 SGTC_628 1636-0253 3.38 16.0 µM 1.96E-4 sphingolipid biosynthesis & PDR1 52 3.68E-4
14 SGTC_3194 9111903 3.15 49.5 µM 4.66E-4 53 8.12E-4
15 SGTC_2380 9035439 3.15 200.0 µM 4.76E-4 endomembrane recycling 69 8.27E-4
16 SGTC_1846 st056244 3.11 14.8 µM 5.47E-4 70 9.40E-4
17 SGTC_3188 9110789 3.09 49.5 µM 5.80E-4 iron homeostasis 62 9.90E-4
18 SGTC_2678 equilin 3.09 100.0 µM 5.93E-4 53 0.00101
19 SGTC_420 mitomycin C 3.07 81.9 mM 6.25E-4 51 0.00106
20 SGTC_65 0798-0905 3.07 35.0 µM 6.25E-4 calcium & mitochondrial duress 154 0.00106

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 6.34E-13 YNL272C SEC2 het Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
0.114 3.90E-11 YHR191C CTF8 hom Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
0.095 3.24E-8 YPL052W OAZ1 hom Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p
0.094 5.10E-8 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.093 6.36E-8 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.093 7.47E-8 YJL029C VPS53 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
0.092 1.01E-7 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.091 1.42E-7 YPR138C MEP3 hom Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
0.088 3.36E-7 YPL074W YTA6 hom Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress
0.085 9.08E-7 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.085 9.40E-7 YLR274W MCM5 het Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
0.084 9.70E-7 YJL013C MAD3 hom Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
0.080 3.29E-6 YGL031C RPL24A hom Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication
0.079 5.23E-6 YLR079W SIC1 hom Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.078 6.91E-6 YHR018C ARG4 hom Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway