YJL146W / IDS2

Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL146W / IDS2

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:4.00|P-value:1.52E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.47|P-value:1.73E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.31|P-value:4.29E-6 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.86|P-value:3.37E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.01|P-value:8.27E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.49|P-value:1.56E-4 ID:SGTC_489|Compound:paxilline|FD-Score:4.43|P-value:1.96E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:3.49|P-value:1.37E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.22|P-value:3.95E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.48|P-value:1.43E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.48|P-value:1.38E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.90|P-value:1.69E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.42|P-value:2.00E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.99|P-value:9.06E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.22|P-value:3.89E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.80|P-value:4.47E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:2.99|P-value:8.92E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.92|P-value:2.14E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.66|P-value:7.84E-5 ID:SGTC_1516|Compound:st013856|FD-Score:3.31|P-value:2.80E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.61|P-value:7.81E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.54|P-value:1.10E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.82|P-value:3.45E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.86|P-value:2.81E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.49|P-value:1.34E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.92|P-value:2.59E-5 ID:SGTC_2955|Compound:9076254|FD-Score:5.13|P-value:4.44E-8 ID:SGTC_2960|Compound:9079389|FD-Score:-6.07|P-value:1.75E-10 ID:SGTC_2989|Compound:9073649|FD-Score:4.68|P-value:5.50E-7 ID:SGTC_2994|Compound:9053520|FD-Score:-4.83|P-value:2.95E-7 ID:SGTC_3101|Compound:9120531|FD-Score:3.09|P-value:6.25E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.00|P-value:1.52E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.47|P-value:1.73E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.31|P-value:4.29E-6 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.86|P-value:3.37E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.01|P-value:8.27E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.49|P-value:1.56E-4 ID:SGTC_489|Compound:paxilline|FD-Score:4.43|P-value:1.96E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:3.49|P-value:1.37E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.22|P-value:3.95E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.48|P-value:1.43E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.48|P-value:1.38E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.90|P-value:1.69E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.42|P-value:2.00E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.99|P-value:9.06E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.22|P-value:3.89E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.80|P-value:4.47E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:2.99|P-value:8.92E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.92|P-value:2.14E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.66|P-value:7.84E-5 ID:SGTC_1516|Compound:st013856|FD-Score:3.31|P-value:2.80E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.61|P-value:7.81E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.54|P-value:1.10E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.82|P-value:3.45E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.86|P-value:2.81E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.49|P-value:1.34E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.92|P-value:2.59E-5 ID:SGTC_2955|Compound:9076254|FD-Score:5.13|P-value:4.44E-8 ID:SGTC_2960|Compound:9079389|FD-Score:-6.07|P-value:1.75E-10 ID:SGTC_2989|Compound:9073649|FD-Score:4.68|P-value:5.50E-7 ID:SGTC_2994|Compound:9053520|FD-Score:-4.83|P-value:2.95E-7 ID:SGTC_3101|Compound:9120531|FD-Score:3.09|P-value:6.25E-4

Top fitness defect scores for YJL146W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2955 9076254 5.13 12.2 µM 4.44E-8 4 1.41E-7
2 SGTC_1120 ficusin 4.90 1.8 µM 1.69E-7 9 4.88E-7
3 SGTC_2989 9073649 4.68 71.4 µM 5.50E-7 17 1.46E-6
4 SGTC_2344 7990960 4.61 77.0 µM 7.81E-7 16 2.02E-6
5 SGTC_489 paxilline 4.43 115.0 µM 1.96E-6 PDR1 8 4.75E-6
6 SGTC_1125 tnp00248 4.42 1.3 µM 2.00E-6 17 4.83E-6
7 SGTC_132 0417-1715 4.00 25.8 µM 1.52E-5 RPP1 & pyrimidine depletion 22 3.17E-5
8 SGTC_1349 flufenamic acid 3.92 69.0 µM 2.14E-5 13 4.37E-5
9 SGTC_2690 usnic acid 3.86 100.0 µM 2.81E-5 29 5.61E-5
10 SGTC_2592 piperlongumine 3.82 83.3 µM 3.45E-5 TSC3-RPN4 47 6.80E-5
11 SGTC_2419 paclitaxel 3.54 166.5 µM 1.10E-4 64 1.99E-4
12 SGTC_2883 9059145 3.49 45.5 µM 1.34E-4 16 2.40E-4
13 SGTC_921 1561-0023 3.49 372.0 µM 1.37E-4 31 2.45E-4
14 SGTC_983 1491-0821 3.48 12.2 µM 1.38E-4 25 2.46E-4
15 SGTC_960 1222-0186 3.48 7.7 µM 1.43E-4 49 2.55E-4
16 SGTC_1516 st013856 3.31 110.0 µM 2.80E-4 28 4.74E-4
17 SGTC_1221 2958-7315 3.22 257.0 µM 3.89E-4 42 6.44E-4
18 SGTC_940 3232-1287 3.22 54.8 µM 3.95E-4 NEO1 71 6.52E-4
19 SGTC_3101 9120531 3.09 49.5 µM 6.25E-4 67 9.99E-4
20 SGTC_451 chloral hydrate 3.01 100.0 µM 8.27E-4 111 0.00130

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.34E-16 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.138 9.55E-16 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.134 5.81E-15 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.125 3.93E-13 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.118 6.05E-12 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.115 2.22E-11 YDL057W_p YDL057W_p hom Putative protein of unknown function; YDL057W is not an essential gene
0.114 3.69E-11 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.49E-10 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.102 3.07E-9 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.098 1.26E-8 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.095 4.21E-8 YGL062W PYC1 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication
0.094 4.97E-8 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.092 8.19E-8 YPL071C_p YPL071C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.092 8.27E-8 YPR056W TFB4 het Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
0.091 1.16E-7 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus