YJL148W / RPA34

RNA polymerase I subunit A34.5

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL148W / RPA34

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.25|P-value:4.99E-7 ID:SGTC_66|Compound:0109-0187|FD-Score:2.88|P-value:3.92E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.66|P-value:1.20E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-6.15|P-value:7.44E-12 ID:SGTC_202|Compound:3594-0513|FD-Score:6.23|P-value:5.90E-13 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.33|P-value:1.64E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-3.19|P-value:3.00E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.96|P-value:7.52E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.28|P-value:2.06E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.94|P-value:2.73E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:3.46|P-value:3.14E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:4.78|P-value:2.05E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:4.10|P-value:1.18E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:8.51|P-value:2.37E-22 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.55|P-value:6.08E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:2.95|P-value:2.94E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.35|P-value:5.32E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.31|P-value:6.32E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.14|P-value:3.59E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.99|P-value:2.53E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.50|P-value:2.53E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.64|P-value:1.33E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.72|P-value:2.76E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.25|P-value:8.33E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.32|P-value:5.88E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.31|P-value:1.81E-4 ID:SGTC_1885|Compound:st057546|FD-Score:2.80|P-value:5.40E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.10|P-value:1.59E-4 ID:SGTC_1923|Compound:st058458|FD-Score:2.67|P-value:9.05E-4 ID:SGTC_1930|Compound:st074634|FD-Score:6.46|P-value:9.46E-14 ID:SGTC_1990|Compound:st072050|FD-Score:-5.00|P-value:2.39E-8 ID:SGTC_1993|Compound:st073995|FD-Score:-4.47|P-value:5.75E-7 ID:SGTC_1995|Compound:st072814|FD-Score:-4.05|P-value:5.52E-6 ID:SGTC_2000|Compound:st075254|FD-Score:3.65|P-value:1.26E-5 ID:SGTC_2088|Compound:5278280|FD-Score:-5.70|P-value:2.20E-10 ID:SGTC_2126|Compound:5251174|FD-Score:3.01|P-value:2.35E-4 ID:SGTC_2298|Compound:7976326|FD-Score:2.67|P-value:8.88E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:2.97|P-value:2.72E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.73|P-value:2.69E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.75|P-value:2.55E-8 ID:SGTC_2650|Compound:prasterone|FD-Score:2.94|P-value:3.14E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.43|P-value:1.56E-17 ID:SGTC_2671|Compound:danthron|FD-Score:3.76|P-value:7.24E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.55|P-value:8.66E-8 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:2.78|P-value:5.98E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.17|P-value:1.15E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.22|P-value:2.58E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-2.97|P-value:6.98E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.89|P-value:3.66E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.71|P-value:8.97E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:4.25|P-value:4.99E-7 ID:SGTC_66|Compound:0109-0187|FD-Score:2.88|P-value:3.92E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.66|P-value:1.20E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-6.15|P-value:7.44E-12 ID:SGTC_202|Compound:3594-0513|FD-Score:6.23|P-value:5.90E-13 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.33|P-value:1.64E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-3.19|P-value:3.00E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.96|P-value:7.52E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.28|P-value:2.06E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.94|P-value:2.73E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:3.46|P-value:3.14E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:4.78|P-value:2.05E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:4.10|P-value:1.18E-6 ID:SGTC_538|Compound:2922-0838|FD-Score:8.51|P-value:2.37E-22 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.55|P-value:6.08E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:2.95|P-value:2.94E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.35|P-value:5.32E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.31|P-value:6.32E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.14|P-value:3.59E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.99|P-value:2.53E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.50|P-value:2.53E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.64|P-value:1.33E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.72|P-value:2.76E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.25|P-value:8.33E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.32|P-value:5.88E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.31|P-value:1.81E-4 ID:SGTC_1885|Compound:st057546|FD-Score:2.80|P-value:5.40E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.10|P-value:1.59E-4 ID:SGTC_1923|Compound:st058458|FD-Score:2.67|P-value:9.05E-4 ID:SGTC_1930|Compound:st074634|FD-Score:6.46|P-value:9.46E-14 ID:SGTC_1990|Compound:st072050|FD-Score:-5.00|P-value:2.39E-8 ID:SGTC_1993|Compound:st073995|FD-Score:-4.47|P-value:5.75E-7 ID:SGTC_1995|Compound:st072814|FD-Score:-4.05|P-value:5.52E-6 ID:SGTC_2000|Compound:st075254|FD-Score:3.65|P-value:1.26E-5 ID:SGTC_2088|Compound:5278280|FD-Score:-5.70|P-value:2.20E-10 ID:SGTC_2126|Compound:5251174|FD-Score:3.01|P-value:2.35E-4 ID:SGTC_2298|Compound:7976326|FD-Score:2.67|P-value:8.88E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:2.97|P-value:2.72E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.73|P-value:2.69E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.75|P-value:2.55E-8 ID:SGTC_2650|Compound:prasterone|FD-Score:2.94|P-value:3.14E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.43|P-value:1.56E-17 ID:SGTC_2671|Compound:danthron|FD-Score:3.76|P-value:7.24E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.55|P-value:8.66E-8 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:2.78|P-value:5.98E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.17|P-value:1.15E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.22|P-value:2.58E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-2.97|P-value:6.98E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.89|P-value:3.66E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.71|P-value:8.97E-6

Top fitness defect scores for YJL148W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_538 2922-0838 8.51 53.3 µM 2.37E-22 Golgi 1 8.75E-18
2 SGTC_241 5hr heat shock (37°C) + cantharidin 7.96 155.4 µM 7.52E-20 cell wall signaling 17 8.28E-16
3 SGTC_2651 1327-0036 7.43 5.0 µM 1.56E-17 42 5.60E-14
4 SGTC_1930 st074634 6.46 34.3 µM 9.46E-14 RNA pol III & RNase P/MRP 8 5.38E-11
5 SGTC_202 3594-0513 6.23 34.8 µM 5.90E-13 PDR1 3 2.28E-10
6 SGTC_534 k292-0788 4.78 63.4 µM 2.05E-8 mitochondrial processes 12 8.58E-7
7 SGTC_2544 sphondin 4.75 68.5 µM 2.55E-8 RNA pol III & RNase P/MRP 12 1.01E-6
8 SGTC_2688 kanamycin b 4.55 96.7 µM 8.66E-8 calcium & mitochondrial duress 291 2.66E-6
9 SGTC_65 0798-0905 4.25 35.0 µM 4.99E-7 calcium & mitochondrial duress 77 1.05E-5
10 SGTC_535 2293-4129 4.10 48.2 µM 1.18E-6 NEO1 55 2.07E-5
11 SGTC_422 cantharidin 3.94 155.0 µM 2.73E-6 cell wall signaling 58 4.00E-5
12 SGTC_3193 9111931 3.89 49.5 µM 3.66E-6 27 5.03E-5
13 SGTC_2671 danthron 3.76 100.0 µM 7.24E-6 DNA damage response 51 8.60E-5
14 SGTC_3194 9111903 3.71 49.5 µM 8.97E-6 28 1.02E-4
15 SGTC_71 0417-1750 3.66 47.8 µM 1.20E-5 Golgi 58 1.28E-4
16 SGTC_2000 st075254 3.65 36.4 µM 1.26E-5 12 1.33E-4
17 SGTC_1207 2099-0101 3.64 141.0 µM 1.33E-5 29 1.39E-4
18 SGTC_1128 3448-9350 3.50 235.0 µM 2.53E-5 37 2.30E-4
19 SGTC_523 1934-0222 3.46 13.7 µM 3.14E-5 44 2.72E-4
20 SGTC_623 k072-0108 3.35 16.9 µM 5.32E-5 heme biosynthesis & mitochondrial translocase 43 4.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.303 1.82E-72 YNL248C RPA49 hom RNA polymerase I subunit A49
0.239 6.94E-45 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.199 3.65E-31 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.189 2.39E-28 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.170 3.32E-23 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.167 1.62E-22 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.165 7.38E-22 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.162 3.39E-21 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.159 1.53E-20 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.157 5.06E-20 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.153 5.28E-19 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.152 9.47E-19 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.145 3.82E-17 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.139 5.96E-16 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.134 7.32E-15 YOL006C TOP1 hom Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination