YJL150W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL150W / YJL150W

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.05|P-value:5.67E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.61|P-value:4.83E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.72|P-value:5.66E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:7.34|P-value:3.99E-15 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.01|P-value:9.23E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.70|P-value:6.13E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.45|P-value:1.69E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.01|P-value:9.24E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.60|P-value:6.26E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.15|P-value:5.43E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.23|P-value:4.12E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.18|P-value:4.96E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.56|P-value:7.62E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.38|P-value:2.32E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.36|P-value:1.72E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.19|P-value:4.73E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.04|P-value:8.60E-6 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.11|P-value:4.60E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:2.90|P-value:9.78E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.31|P-value:2.32E-6 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.37|P-value:1.62E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.99|P-value:7.16E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.41|P-value:1.99E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.54|P-value:1.18E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.15|P-value:5.54E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.72|P-value:3.85E-5 ID:SGTC_2432|Compound:5630864|FD-Score:4.94|P-value:8.02E-8 ID:SGTC_2434|Compound:5670830|FD-Score:3.87|P-value:1.95E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.15|P-value:3.93E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.05|P-value:8.47E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.53|P-value:8.46E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.12|P-value:4.46E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.25|P-value:2.69E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.28|P-value:3.31E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.64|P-value:5.31E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.32|P-value:2.28E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.23|P-value:2.93E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.20|P-value:3.17E-4 ID:SGTC_3272|Compound:9137413|FD-Score:2.91|P-value:9.56E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.52|P-value:8.91E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:3.05|P-value:5.67E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.61|P-value:4.83E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.72|P-value:5.66E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:7.34|P-value:3.99E-15 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.01|P-value:9.23E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.70|P-value:6.13E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.45|P-value:1.69E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.01|P-value:9.24E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.60|P-value:6.26E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.15|P-value:5.43E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.23|P-value:4.12E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.18|P-value:4.96E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.56|P-value:7.62E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.38|P-value:2.32E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.36|P-value:1.72E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.19|P-value:4.73E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.04|P-value:8.60E-6 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.11|P-value:4.60E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:2.90|P-value:9.78E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.31|P-value:2.32E-6 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.37|P-value:1.62E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.99|P-value:7.16E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.41|P-value:1.99E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.54|P-value:1.18E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.15|P-value:5.54E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.72|P-value:3.85E-5 ID:SGTC_2432|Compound:5630864|FD-Score:4.94|P-value:8.02E-8 ID:SGTC_2434|Compound:5670830|FD-Score:3.87|P-value:1.95E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.15|P-value:3.93E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.05|P-value:8.47E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.53|P-value:8.46E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.12|P-value:4.46E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.25|P-value:2.69E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.28|P-value:3.31E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.64|P-value:5.31E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.32|P-value:2.28E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.23|P-value:2.93E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.20|P-value:3.17E-4 ID:SGTC_3272|Compound:9137413|FD-Score:2.91|P-value:9.56E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.52|P-value:8.91E-5

Top fitness defect scores for YJL150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 7.34 35.0 µM 3.99E-15 calcium & mitochondrial duress 17 1.03E-13
2 SGTC_2432 5630864 4.94 12.2 µM 8.02E-8 9 3.91E-7
3 SGTC_58 0957-0393 4.61 9.0 µM 4.83E-7 cell wall 321 1.97E-6
4 SGTC_2920 7982904 4.32 15.8 µM 2.28E-6 13 7.95E-6
5 SGTC_1479 0549-0158 4.31 134.0 µM 2.32E-6 14 8.09E-6
6 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.05 100.0 µM 8.47E-6 34 2.59E-5
7 SGTC_1040 k898-0338 4.04 155.0 µM 8.60E-6 19 2.63E-5
8 SGTC_2434 5670830 3.87 169.9 µM 1.95E-5 29 5.50E-5
9 SGTC_2429 5902844 3.72 64.4 µM 3.85E-5 32 1.01E-4
10 SGTC_2918 7977171 3.64 22.1 µM 5.31E-5 37 1.35E-4
11 SGTC_656 4090-1979 3.60 187.0 µM 6.26E-5 29 1.57E-4
12 SGTC_960 1222-0186 3.56 7.7 µM 7.62E-5 43 1.87E-4
13 SGTC_2636 apigenin dimethyl ether 3.53 100.0 µM 8.46E-5 60 2.06E-4
14 SGTC_3305 9127027 3.52 53.8 µM 8.91E-5 30 2.16E-4
15 SGTC_1501 4491-0275 3.37 38.4 µM 1.62E-4 24 3.70E-4
16 SGTC_1014 4130-3005 3.36 69.3 µM 1.72E-4 40 3.90E-4
17 SGTC_2810 7959871 3.25 45.5 µM 2.69E-4 copper-dependent oxidative stress 72 5.83E-4
18 SGTC_3157 9099274 3.23 49.5 µM 2.93E-4 41 6.29E-4
19 SGTC_3246 9135460 3.20 33.0 µM 3.17E-4 15 6.76E-4
20 SGTC_2564 betulinic acid 3.15 100.0 µM 3.93E-4 66 8.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 2.78E-57 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.170 3.89E-23 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.161 6.92E-21 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.160 1.17E-20 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.157 4.61E-20 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.150 2.24E-18 YHR125W_d YHR125W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148 5.67E-18 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.147 9.23E-18 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.145 2.41E-17 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.141 1.86E-16 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.141 2.20E-16 YGR106C VOA1 hom Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
0.139 5.18E-16 YJL187C SWE1 hom Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
0.137 1.40E-15 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.135 3.52E-15 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.135 4.77E-15 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene