YJL152W_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL152W / YJL152W

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:-2.51|P-value:8.62E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-2.69|P-value:4.01E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:2.64|P-value:2.89E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.93|P-value:1.80E-7 ID:SGTC_284|Compound:0988-0104|FD-Score:2.95|P-value:6.28E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.61|P-value:2.99E-6 ID:SGTC_306|Compound:1672-3436|FD-Score:2.88|P-value:9.01E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:2.86|P-value:9.99E-5 ID:SGTC_398|Compound:bronopol|FD-Score:2.44|P-value:7.21E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:2.83|P-value:1.17E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:-2.61|P-value:5.67E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:2.84|P-value:1.10E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-2.79|P-value:2.46E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:2.86|P-value:9.97E-5 ID:SGTC_918|Compound:glabranin|FD-Score:-3.60|P-value:3.08E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.31|P-value:1.71E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-2.72|P-value:3.36E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.58|P-value:3.59E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.01|P-value:4.71E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.54|P-value:4.79E-13 ID:SGTC_1173|Compound:0443-0020|FD-Score:-2.52|P-value:8.26E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:2.97|P-value:5.70E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.57|P-value:1.87E-6 ID:SGTC_1710|Compound:st031758|FD-Score:2.50|P-value:5.50E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-2.86|P-value:1.75E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.63|P-value:5.18E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-2.72|P-value:3.35E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.29|P-value:1.83E-5 ID:SGTC_2038|Compound:4100038|FD-Score:2.37|P-value:9.72E-4 ID:SGTC_2112|Compound:5488546|FD-Score:2.51|P-value:5.29E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-2.58|P-value:6.49E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:2.61|P-value:3.30E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.31|P-value:1.66E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.36|P-value:6.50E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-3.63|P-value:2.54E-6 ID:SGTC_2715|Compound:st079500|FD-Score:-3.14|P-value:4.27E-5 ID:SGTC_2820|Compound:7989630|FD-Score:4.07|P-value:6.89E-8 ID:SGTC_2822|Compound:7994718|FD-Score:-5.27|P-value:1.47E-11 ID:SGTC_3060|Compound:1327-0027|FD-Score:2.44|P-value:7.29E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.43|P-value:7.52E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.07|P-value:3.32E-5 ID:SGTC_3190|Compound:9110366|FD-Score:2.60|P-value:3.59E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-2.80|P-value:2.33E-4 ID:SGTC_3305|Compound:9127027|FD-Score:2.40|P-value:8.58E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-2.51|P-value:8.62E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-2.69|P-value:4.01E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:2.64|P-value:2.89E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.93|P-value:1.80E-7 ID:SGTC_284|Compound:0988-0104|FD-Score:2.95|P-value:6.28E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.61|P-value:2.99E-6 ID:SGTC_306|Compound:1672-3436|FD-Score:2.88|P-value:9.01E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:2.86|P-value:9.99E-5 ID:SGTC_398|Compound:bronopol|FD-Score:2.44|P-value:7.21E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:2.83|P-value:1.17E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:-2.61|P-value:5.67E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:2.84|P-value:1.10E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-2.79|P-value:2.46E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:2.86|P-value:9.97E-5 ID:SGTC_918|Compound:glabranin|FD-Score:-3.60|P-value:3.08E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.31|P-value:1.71E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-2.72|P-value:3.36E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.58|P-value:3.59E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.01|P-value:4.71E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.54|P-value:4.79E-13 ID:SGTC_1173|Compound:0443-0020|FD-Score:-2.52|P-value:8.26E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:2.97|P-value:5.70E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.57|P-value:1.87E-6 ID:SGTC_1710|Compound:st031758|FD-Score:2.50|P-value:5.50E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-2.86|P-value:1.75E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.63|P-value:5.18E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-2.72|P-value:3.35E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.29|P-value:1.83E-5 ID:SGTC_2038|Compound:4100038|FD-Score:2.37|P-value:9.72E-4 ID:SGTC_2112|Compound:5488546|FD-Score:2.51|P-value:5.29E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-2.58|P-value:6.49E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:2.61|P-value:3.30E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.31|P-value:1.66E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.36|P-value:6.50E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-3.63|P-value:2.54E-6 ID:SGTC_2715|Compound:st079500|FD-Score:-3.14|P-value:4.27E-5 ID:SGTC_2820|Compound:7989630|FD-Score:4.07|P-value:6.89E-8 ID:SGTC_2822|Compound:7994718|FD-Score:-5.27|P-value:1.47E-11 ID:SGTC_3060|Compound:1327-0027|FD-Score:2.44|P-value:7.29E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.43|P-value:7.52E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.07|P-value:3.32E-5 ID:SGTC_3190|Compound:9110366|FD-Score:2.60|P-value:3.59E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-2.80|P-value:2.33E-4 ID:SGTC_3305|Compound:9127027|FD-Score:2.40|P-value:8.58E-4

Top fitness defect scores for YJL152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1061 3448-9325 5.54 110.0 µM 4.79E-13 3 1.52E-8
2 SGTC_2820 7989630 4.07 71.4 µM 6.89E-8 ERG2 17 2.31E-5
3 SGTC_280 3448-3607 3.93 3.0 µM 1.80E-7 60S ribosome export 9 4.18E-5
4 SGTC_1704 st028805 3.57 70.8 µM 1.87E-6 18 1.79E-4
5 SGTC_2617 dihydrotanshinone i 3.36 20.8 µM 6.50E-6 copper-dependent oxidative stress 71 3.87E-4
6 SGTC_3136 9095672 3.07 49.5 µM 3.32E-5 61 0.00107
7 SGTC_1058 3448-5425 3.01 97.3 µM 4.71E-5 63 0.00133
8 SGTC_1500 4488-1866 2.97 171.0 µM 5.70E-5 RPP1 & pyrimidine depletion 63 0.00150
9 SGTC_284 0988-0104 2.95 32.6 µM 6.28E-5 heme requiring 38 0.00159
10 SGTC_306 1672-3436 2.88 11.6 µM 9.01E-5 Golgi 60 0.00199
11 SGTC_851 0394-0702 2.86 453.0 µM 9.97E-5 mitochondrial processes 54 0.00212
12 SGTC_307 1501-1223 2.86 22.3 µM 9.99E-5 50 0.00212
13 SGTC_520 3584-0023 2.84 682.0 µM 1.10E-4 83 0.00225
14 SGTC_402 epigallocatechin gallate 2.83 10.0 µM 1.17E-4 97 0.00234
15 SGTC_237 nikkomycin 2.64 200.0 µM 2.89E-4 RSC complex & mRNA processing 89 0.00412
16 SGTC_2532 xanthone 2.61 78.9 µM 3.30E-4 108 0.00448
17 SGTC_3190 9110366 2.60 49.5 µM 3.59E-4 70 0.00472
18 SGTC_2112 5488546 2.51 200.0 µM 5.29E-4 TSC3-RPN4 111 0.00602
19 SGTC_1710 st031758 2.50 61.5 µM 5.50E-4 88 0.00617
20 SGTC_398 bronopol 2.44 33.3 µM 7.21E-4 RNA processing & uracil transport 126 0.00732

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.46E-14 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.114 3.20E-11 YPL070W MUK1 hom Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
0.114 3.71E-11 YKL078W DHR2 het Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
0.114 3.77E-11 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.106 8.32E-10 YLR389C STE23 hom Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family
0.098 1.29E-8 YOL057W YOL057W hom Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
0.093 7.47E-8 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.092 9.42E-8 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.090 1.97E-7 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.088 3.59E-7 YOL154W ZPS1 hom Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
0.087 4.81E-7 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.086 5.37E-7 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.086 5.35E-7 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.084 9.97E-7 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.084 1.07E-6 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal