YJL153C / INO1

Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL153C / INO1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.84|P-value:1.07E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:25.80|P-value:7.97E-139 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:5.49|P-value:5.61E-8 ID:SGTC_538|Compound:2922-0838|FD-Score:4.56|P-value:5.17E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:3.87|P-value:9.41E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.21|P-value:9.91E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.30|P-value:7.19E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.70|P-value:1.47E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.29|P-value:6.40E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.83|P-value:1.10E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.21|P-value:9.80E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.45|P-value:3.67E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.47|P-value:4.07E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.74|P-value:1.52E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.24|P-value:7.63E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.31|P-value:7.00E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.24|P-value:7.71E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.23|P-value:9.16E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.49|P-value:3.22E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.19|P-value:8.98E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.28|P-value:7.75E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.22|P-value:9.52E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.71|P-value:1.42E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.39|P-value:4.50E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.21|P-value:2.40E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.95|P-value:5.64E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.23|P-value:7.84E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.82|P-value:9.51E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.41|P-value:5.04E-4 ID:SGTC_2868|Compound:9035608|FD-Score:5.82|P-value:9.02E-9 ID:SGTC_2876|Compound:9059903|FD-Score:3.29|P-value:7.68E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.03|P-value:4.95E-5 ID:SGTC_2978|Compound:9011784|FD-Score:4.09|P-value:3.93E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.69|P-value:1.86E-4 ID:SGTC_3165|Compound:9101544|FD-Score:6.58|P-value:9.77E-11 ID:SGTC_3168|Compound:9103419|FD-Score:3.39|P-value:5.33E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.64|P-value:1.87E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.43|P-value:9.51E-6 ID:SGTC_3203|Compound:9113543|FD-Score:4.54|P-value:5.73E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-3.97|P-value:5.14E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.66|P-value:1.73E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.14|P-value:3.20E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.84|P-value:1.07E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:25.80|P-value:7.97E-139 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:5.49|P-value:5.61E-8 ID:SGTC_538|Compound:2922-0838|FD-Score:4.56|P-value:5.17E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:3.87|P-value:9.41E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.21|P-value:9.91E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.30|P-value:7.19E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.70|P-value:1.47E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.29|P-value:6.40E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.83|P-value:1.10E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.21|P-value:9.80E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.45|P-value:3.67E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.47|P-value:4.07E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.74|P-value:1.52E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.24|P-value:7.63E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.31|P-value:7.00E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.24|P-value:7.71E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.23|P-value:9.16E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.49|P-value:3.22E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.19|P-value:8.98E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.28|P-value:7.75E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.22|P-value:9.52E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.71|P-value:1.42E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.39|P-value:4.50E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.21|P-value:2.40E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.95|P-value:5.64E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.23|P-value:7.84E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.82|P-value:9.51E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.41|P-value:5.04E-4 ID:SGTC_2868|Compound:9035608|FD-Score:5.82|P-value:9.02E-9 ID:SGTC_2876|Compound:9059903|FD-Score:3.29|P-value:7.68E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.03|P-value:4.95E-5 ID:SGTC_2978|Compound:9011784|FD-Score:4.09|P-value:3.93E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.69|P-value:1.86E-4 ID:SGTC_3165|Compound:9101544|FD-Score:6.58|P-value:9.77E-11 ID:SGTC_3168|Compound:9103419|FD-Score:3.39|P-value:5.33E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.64|P-value:1.87E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.43|P-value:9.51E-6 ID:SGTC_3203|Compound:9113543|FD-Score:4.54|P-value:5.73E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-3.97|P-value:5.14E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.66|P-value:1.73E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.14|P-value:3.20E-5

Top fitness defect scores for YJL153C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_309 k408-0051 25.80 1.5 µM 7.97E-139 1 2.93E-147
2 SGTC_3165 9101544 6.58 49.5 µM 9.77E-11 2 2.41E-11
3 SGTC_2868 9035608 5.82 32.5 µM 9.02E-9 3 2.94E-9
4 SGTC_437 s-farnesyl-l-cysteine methyl ester 5.49 6.7 µM 5.61E-8 2 2.05E-8
5 SGTC_538 2922-0838 4.56 53.3 µM 5.17E-6 Golgi 19 2.51E-6
6 SGTC_3203 9113543 4.54 49.5 µM 5.73E-6 18 2.80E-6
7 SGTC_3202 9113761 4.43 49.5 µM 9.51E-6 32 4.79E-6
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.21 3.7 µM 2.40E-5 69 1.28E-5
9 SGTC_3293 9120939 4.14 62.0 µM 3.20E-5 17 1.74E-5
10 SGTC_2978 9011784 4.09 43.0 µM 3.93E-5 23 2.17E-5
11 SGTC_2878 9043973 4.03 26.0 µM 4.95E-5 18 2.77E-5
12 SGTC_551 k048-0028 3.87 34.9 µM 9.41E-5 16 5.47E-5
13 SGTC_6 0844-0013 3.84 19.8 µM 1.07E-4 98 6.25E-5
14 SGTC_783 0848-0141 3.83 92.7 µM 1.10E-4 RSC & ERG11 18 6.49E-5
15 SGTC_1200 1643-0193 3.74 18.4 µM 1.52E-4 25 9.12E-5
16 SGTC_3160 9100216 3.69 49.5 µM 1.86E-4 10 1.13E-4
17 SGTC_1184 1269-1718 3.47 139.0 µM 4.07E-4 47 2.60E-4
18 SGTC_2693 st077581 3.41 40.7 µM 5.04E-4 62 3.26E-4
19 SGTC_3168 9103419 3.39 49.5 µM 5.33E-4 60S ribosome export 11 3.45E-4
20 SGTC_1603 st002045 3.31 67.8 µM 7.00E-4 TSC3-RPN4 35 4.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.502 6.14E-213 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.245 4.01E-47 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.212 2.58E-35 YMR229C RRP5 het RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress
0.204 1.06E-32 YKL175W ZRT3 hom Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
0.180 6.76E-26 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.161 7.59E-21 YJL084C ALY2 hom Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication
0.149 4.80E-18 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.147 1.02E-17 YKR059W TIF1 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication
0.145 3.91E-17 YNL023C FAP1 hom Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
0.138 9.28E-16 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.138 1.14E-15 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.138 1.31E-15 YKL056C TMA19 hom Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
0.137 1.82E-15 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.135 4.84E-15 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.132 1.50E-14 YNL182C IPI3 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene