YJL154C / VPS35

Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL154C / VPS35

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:5.21|P-value:4.89E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:4.38|P-value:1.01E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.97|P-value:1.69E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:5.65|P-value:7.87E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:7.14|P-value:6.35E-10 ID:SGTC_146|Compound:3448-8650|FD-Score:16.40|P-value:1.99E-44 ID:SGTC_149|Compound:3970-0822|FD-Score:4.35|P-value:1.10E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.12|P-value:2.34E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:5.34|P-value:2.91E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:7.55|P-value:6.88E-11 ID:SGTC_172|Compound:1112-0046|FD-Score:8.50|P-value:2.41E-13 ID:SGTC_197|Compound:4544-0043|FD-Score:5.19|P-value:5.29E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:18.60|P-value:1.65E-56 ID:SGTC_221|Compound:trifluoperazine|FD-Score:33.30|P-value:1.05E-177 ID:SGTC_227|Compound:fluconazole|FD-Score:6.28|P-value:4.65E-8 ID:SGTC_232|Compound:clozapine|FD-Score:20.90|P-value:2.62E-71 ID:SGTC_263|Compound:alizarin|FD-Score:6.73|P-value:5.21E-9 ID:SGTC_301|Compound:4119-0100|FD-Score:19.60|P-value:5.23E-63 ID:SGTC_308|Compound:4092-1169|FD-Score:3.74|P-value:7.57E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:8.16|P-value:1.92E-12 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.82|P-value:5.45E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.84|P-value:5.59E-4 ID:SGTC_443|Compound:clozapine|FD-Score:8.76|P-value:4.79E-14 ID:SGTC_445|Compound:e6 berbamine|FD-Score:20.40|P-value:1.42E-67 ID:SGTC_447|Compound:ml7|FD-Score:10.40|P-value:4.66E-19 ID:SGTC_449|Compound:xestospongin c|FD-Score:16.10|P-value:2.70E-43 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-15.30|P-value:1.98E-39 ID:SGTC_455|Compound:paf C-16|FD-Score:-4.54|P-value:5.19E-5 ID:SGTC_459|Compound:nigericin|FD-Score:7.13|P-value:6.71E-10 ID:SGTC_525|Compound:k781-2675|FD-Score:5.66|P-value:7.73E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:4.37|P-value:1.04E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:16.80|P-value:7.06E-47 ID:SGTC_535|Compound:2293-4129|FD-Score:24.90|P-value:4.63E-100 ID:SGTC_562|Compound:3772-2733|FD-Score:9.76|P-value:5.28E-17 ID:SGTC_577|Compound:r071-0003|FD-Score:6.58|P-value:1.10E-8 ID:SGTC_624|Compound:k048-0052|FD-Score:3.82|P-value:5.91E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.81|P-value:6.10E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:8.37|P-value:5.48E-13 ID:SGTC_658|Compound:3253-0951|FD-Score:5.22|P-value:4.56E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:4.90|P-value:1.60E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:4.93|P-value:1.41E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:4.25|P-value:1.53E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:10.40|P-value:4.53E-19 ID:SGTC_900|Compound:1112-0045|FD-Score:7.74|P-value:2.36E-11 ID:SGTC_940|Compound:3232-1287|FD-Score:4.92|P-value:1.47E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.33|P-value:1.17E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.12|P-value:2.38E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:5.30|P-value:3.41E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.80|P-value:4.09E-7 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.69|P-value:8.83E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.88|P-value:4.90E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.13|P-value:9.45E-8 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.90|P-value:4.19E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-4.80|P-value:2.02E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.99|P-value:3.53E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.24|P-value:1.42E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.60|P-value:4.71E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.49|P-value:1.56E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.78|P-value:6.70E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.69|P-value:8.03E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.31|P-value:2.63E-10 ID:SGTC_1647|Compound:st011722|FD-Score:4.13|P-value:2.30E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.05|P-value:2.94E-4 ID:SGTC_1665|Compound:st014639|FD-Score:6.34|P-value:3.57E-8 ID:SGTC_1675|Compound:st018485|FD-Score:-4.21|P-value:1.59E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.78|P-value:2.47E-5 ID:SGTC_1712|Compound:st032288|FD-Score:8.83|P-value:2.90E-14 ID:SGTC_1754|Compound:st042065|FD-Score:23.60|P-value:7.08E-90 ID:SGTC_1760|Compound:st045453|FD-Score:34.80|P-value:7.09E-193 ID:SGTC_1781|Compound:st038725|FD-Score:11.00|P-value:2.81E-21 ID:SGTC_1797|Compound:st048695|FD-Score:10.90|P-value:1.11E-20 ID:SGTC_1800|Compound:st050079|FD-Score:5.60|P-value:9.60E-7 ID:SGTC_1801|Compound:st050089|FD-Score:9.39|P-value:6.71E-16 ID:SGTC_1803|Compound:st050068|FD-Score:9.76|P-value:5.17E-17 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.20|P-value:6.18E-22 ID:SGTC_1972|Compound:st070201|FD-Score:6.62|P-value:9.05E-9 ID:SGTC_1991|Compound:st073000|FD-Score:13.60|P-value:4.52E-31 ID:SGTC_2006|Compound:4011487|FD-Score:8.46|P-value:3.20E-13 ID:SGTC_2009|Compound:4012297|FD-Score:3.65|P-value:9.76E-4 ID:SGTC_2021|Compound:4019055|FD-Score:8.39|P-value:4.77E-13 ID:SGTC_2036|Compound:5160441|FD-Score:5.56|P-value:1.17E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.17|P-value:3.18E-15 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.84|P-value:5.55E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.77|P-value:6.88E-4 ID:SGTC_2284|Compound:7945075|FD-Score:5.70|P-value:6.37E-7 ID:SGTC_2288|Compound:7946289|FD-Score:5.38|P-value:2.43E-6 ID:SGTC_2322|Compound:7413319|FD-Score:7.20|P-value:4.56E-10 ID:SGTC_2398|Compound:5228213|FD-Score:5.67|P-value:7.20E-7 ID:SGTC_2455|Compound:5377712|FD-Score:-3.62|P-value:9.64E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.53|P-value:5.96E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.17|P-value:1.99E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.10|P-value:2.69E-25 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.58|P-value:5.70E-11 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:18.50|P-value:2.16E-56 ID:SGTC_2717|Compound:st081029|FD-Score:3.77|P-value:6.96E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.31|P-value:4.08E-8 ID:SGTC_2978|Compound:9011784|FD-Score:4.46|P-value:7.53E-5 ID:SGTC_2984|Compound:9022109|FD-Score:-4.77|P-value:2.27E-5 ID:SGTC_2985|Compound:9022375|FD-Score:9.02|P-value:8.54E-15 ID:SGTC_2987|Compound:9018338|FD-Score:-6.81|P-value:3.09E-9 ID:SGTC_3018|Compound:9082602|FD-Score:5.98|P-value:1.90E-7 ID:SGTC_3037|Compound:9091026|FD-Score:5.22|P-value:4.71E-6 ID:SGTC_3081|Compound:9117243|FD-Score:4.32|P-value:1.21E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.64|P-value:8.15E-9 ID:SGTC_3328|Compound:9140624|FD-Score:4.28|P-value:1.41E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:5.21|P-value:4.89E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:4.38|P-value:1.01E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.97|P-value:1.69E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:5.65|P-value:7.87E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:7.14|P-value:6.35E-10 ID:SGTC_146|Compound:3448-8650|FD-Score:16.40|P-value:1.99E-44 ID:SGTC_149|Compound:3970-0822|FD-Score:4.35|P-value:1.10E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.12|P-value:2.34E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:5.34|P-value:2.91E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:7.55|P-value:6.88E-11 ID:SGTC_172|Compound:1112-0046|FD-Score:8.50|P-value:2.41E-13 ID:SGTC_197|Compound:4544-0043|FD-Score:5.19|P-value:5.29E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:18.60|P-value:1.65E-56 ID:SGTC_221|Compound:trifluoperazine|FD-Score:33.30|P-value:1.05E-177 ID:SGTC_227|Compound:fluconazole|FD-Score:6.28|P-value:4.65E-8 ID:SGTC_232|Compound:clozapine|FD-Score:20.90|P-value:2.62E-71 ID:SGTC_263|Compound:alizarin|FD-Score:6.73|P-value:5.21E-9 ID:SGTC_301|Compound:4119-0100|FD-Score:19.60|P-value:5.23E-63 ID:SGTC_308|Compound:4092-1169|FD-Score:3.74|P-value:7.57E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:8.16|P-value:1.92E-12 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.82|P-value:5.45E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.84|P-value:5.59E-4 ID:SGTC_443|Compound:clozapine|FD-Score:8.76|P-value:4.79E-14 ID:SGTC_445|Compound:e6 berbamine|FD-Score:20.40|P-value:1.42E-67 ID:SGTC_447|Compound:ml7|FD-Score:10.40|P-value:4.66E-19 ID:SGTC_449|Compound:xestospongin c|FD-Score:16.10|P-value:2.70E-43 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-15.30|P-value:1.98E-39 ID:SGTC_455|Compound:paf C-16|FD-Score:-4.54|P-value:5.19E-5 ID:SGTC_459|Compound:nigericin|FD-Score:7.13|P-value:6.71E-10 ID:SGTC_525|Compound:k781-2675|FD-Score:5.66|P-value:7.73E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:4.37|P-value:1.04E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:16.80|P-value:7.06E-47 ID:SGTC_535|Compound:2293-4129|FD-Score:24.90|P-value:4.63E-100 ID:SGTC_562|Compound:3772-2733|FD-Score:9.76|P-value:5.28E-17 ID:SGTC_577|Compound:r071-0003|FD-Score:6.58|P-value:1.10E-8 ID:SGTC_624|Compound:k048-0052|FD-Score:3.82|P-value:5.91E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.81|P-value:6.10E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:8.37|P-value:5.48E-13 ID:SGTC_658|Compound:3253-0951|FD-Score:5.22|P-value:4.56E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:4.90|P-value:1.60E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:4.93|P-value:1.41E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:4.25|P-value:1.53E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:10.40|P-value:4.53E-19 ID:SGTC_900|Compound:1112-0045|FD-Score:7.74|P-value:2.36E-11 ID:SGTC_940|Compound:3232-1287|FD-Score:4.92|P-value:1.47E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:4.33|P-value:1.17E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.12|P-value:2.38E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:5.30|P-value:3.41E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.80|P-value:4.09E-7 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.69|P-value:8.83E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.88|P-value:4.90E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.13|P-value:9.45E-8 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.90|P-value:4.19E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-4.80|P-value:2.02E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.99|P-value:3.53E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.24|P-value:1.42E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.60|P-value:4.71E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.49|P-value:1.56E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.78|P-value:6.70E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.69|P-value:8.03E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.31|P-value:2.63E-10 ID:SGTC_1647|Compound:st011722|FD-Score:4.13|P-value:2.30E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.05|P-value:2.94E-4 ID:SGTC_1665|Compound:st014639|FD-Score:6.34|P-value:3.57E-8 ID:SGTC_1675|Compound:st018485|FD-Score:-4.21|P-value:1.59E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.78|P-value:2.47E-5 ID:SGTC_1712|Compound:st032288|FD-Score:8.83|P-value:2.90E-14 ID:SGTC_1754|Compound:st042065|FD-Score:23.60|P-value:7.08E-90 ID:SGTC_1760|Compound:st045453|FD-Score:34.80|P-value:7.09E-193 ID:SGTC_1781|Compound:st038725|FD-Score:11.00|P-value:2.81E-21 ID:SGTC_1797|Compound:st048695|FD-Score:10.90|P-value:1.11E-20 ID:SGTC_1800|Compound:st050079|FD-Score:5.60|P-value:9.60E-7 ID:SGTC_1801|Compound:st050089|FD-Score:9.39|P-value:6.71E-16 ID:SGTC_1803|Compound:st050068|FD-Score:9.76|P-value:5.17E-17 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.20|P-value:6.18E-22 ID:SGTC_1972|Compound:st070201|FD-Score:6.62|P-value:9.05E-9 ID:SGTC_1991|Compound:st073000|FD-Score:13.60|P-value:4.52E-31 ID:SGTC_2006|Compound:4011487|FD-Score:8.46|P-value:3.20E-13 ID:SGTC_2009|Compound:4012297|FD-Score:3.65|P-value:9.76E-4 ID:SGTC_2021|Compound:4019055|FD-Score:8.39|P-value:4.77E-13 ID:SGTC_2036|Compound:5160441|FD-Score:5.56|P-value:1.17E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.17|P-value:3.18E-15 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.84|P-value:5.55E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.77|P-value:6.88E-4 ID:SGTC_2284|Compound:7945075|FD-Score:5.70|P-value:6.37E-7 ID:SGTC_2288|Compound:7946289|FD-Score:5.38|P-value:2.43E-6 ID:SGTC_2322|Compound:7413319|FD-Score:7.20|P-value:4.56E-10 ID:SGTC_2398|Compound:5228213|FD-Score:5.67|P-value:7.20E-7 ID:SGTC_2455|Compound:5377712|FD-Score:-3.62|P-value:9.64E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.53|P-value:5.96E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.17|P-value:1.99E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.10|P-value:2.69E-25 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.58|P-value:5.70E-11 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:18.50|P-value:2.16E-56 ID:SGTC_2717|Compound:st081029|FD-Score:3.77|P-value:6.96E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.31|P-value:4.08E-8 ID:SGTC_2978|Compound:9011784|FD-Score:4.46|P-value:7.53E-5 ID:SGTC_2984|Compound:9022109|FD-Score:-4.77|P-value:2.27E-5 ID:SGTC_2985|Compound:9022375|FD-Score:9.02|P-value:8.54E-15 ID:SGTC_2987|Compound:9018338|FD-Score:-6.81|P-value:3.09E-9 ID:SGTC_3018|Compound:9082602|FD-Score:5.98|P-value:1.90E-7 ID:SGTC_3037|Compound:9091026|FD-Score:5.22|P-value:4.71E-6 ID:SGTC_3081|Compound:9117243|FD-Score:4.32|P-value:1.21E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.64|P-value:8.15E-9 ID:SGTC_3328|Compound:9140624|FD-Score:4.28|P-value:1.41E-4

Top fitness defect scores for YJL154C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1760 st045453 34.80 10.4 µM 7.09E-193 NEO1-PIK1 2 5.19E-265
2 SGTC_221 trifluoperazine 33.30 10.3 µM 1.05E-177 NEO1-PIK1 1 4.10E-244
3 SGTC_535 2293-4129 24.90 48.2 µM 4.63E-100 NEO1 2 3.79E-137
4 SGTC_1754 st042065 23.60 16.1 µM 7.08E-90 NEO1-PIK1 2 4.06E-123
5 SGTC_232 clozapine 20.90 119.0 µM 2.62E-71 NEO1 4 1.53E-97
6 SGTC_445 e6 berbamine 20.40 66.0 µM 1.42E-67 NEO1-PIK1 1 2.13E-92
7 SGTC_301 4119-0100 19.60 24.5 µM 5.23E-63 NEO1 3 4.13E-86
8 SGTC_206 4546-0025 18.60 72.0 µM 1.65E-56 NEO1 3 3.68E-77
9 SGTC_2697 mebhydrolin 18.50 72.4 µM 2.16E-56 NEO1 6 5.35E-77
10 SGTC_528 3492-0019 16.80 172.0 µM 7.06E-47 calcium & mitochondrial duress 6 6.76E-64
11 SGTC_146 3448-8650 16.40 53.1 µM 1.99E-44 NEO1-PIK1 5 1.59E-60
12 SGTC_449 xestospongin c 16.10 11.2 µM 2.70E-43 NEO1-PIK1 1 5.79E-59
13 SGTC_1991 st073000 13.60 8.9 µM 4.52E-31 NEO1 6 3.90E-42
14 SGTC_2679 rapamycin 12.10 1.0 nM 2.69E-25 17 3.45E-34
15 SGTC_1844 rapamycin 11.20 4.0 nM 6.18E-22 29 1.45E-29
16 SGTC_1781 st038725 11.00 66.3 µM 2.81E-21 NEO1 14 1.16E-28
17 SGTC_1797 st048695 10.90 56.8 µM 1.11E-20 NEO1 16 7.65E-28
18 SGTC_888 0916-0002 10.40 7.0 µM 4.53E-19 NEO1 10 1.26E-25
19 SGTC_447 ml7 10.40 120.0 µM 4.66E-19 NEO1-PIK1 2 1.31E-25
20 SGTC_1803 st050068 9.76 52.4 µM 5.17E-17 NEO1-PIK1 26 8.49E-23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.731 0 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.718 0 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.653 0 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.583 2.43E-304 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.581 8.22E-303 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.574 1.78E-293 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.540 1.05E-252 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.538 9.47E-251 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.536 1.51E-249 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.520 8.56E-231 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.504 3.86E-215 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.502 3.48E-213 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.491 2.06E-202 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.468 2.30E-182 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.466 2.50E-179 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit