YJL166W / QCR8

Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL166W / QCR8

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:6.03|P-value:4.26E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:2.94|P-value:7.75E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:34.00|P-value:5.74E-294 ID:SGTC_275|Compound:trichlorophene|FD-Score:2.94|P-value:7.77E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.99|P-value:8.90E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:6.02|P-value:4.61E-11 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.10|P-value:4.22E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.95|P-value:7.44E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.16|P-value:3.26E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:16.90|P-value:1.15E-74 ID:SGTC_435|Compound:c-PAF|FD-Score:2.95|P-value:7.43E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.03|P-value:5.51E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.61|P-value:5.03E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.04|P-value:5.37E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.90|P-value:8.79E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.31|P-value:1.83E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.86|P-value:1.62E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.11|P-value:4.73E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:2.97|P-value:6.95E-4 ID:SGTC_1635|Compound:st007035|FD-Score:22.40|P-value:1.16E-128 ID:SGTC_1637|Compound:st007924|FD-Score:-3.79|P-value:2.25E-5 ID:SGTC_1799|Compound:st045822|FD-Score:4.14|P-value:4.28E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-2.93|P-value:7.84E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.94|P-value:5.17E-8 ID:SGTC_2473|Compound:5854593|FD-Score:-2.87|P-value:9.89E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.11|P-value:4.12E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:2.95|P-value:7.52E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.03|P-value:7.23E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:3.00|P-value:6.22E-4 ID:SGTC_2534|Compound:helenine|FD-Score:4.96|P-value:4.77E-8 ID:SGTC_2537|Compound:larixol|FD-Score:7.38|P-value:9.69E-16 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.28|P-value:2.02E-6 ID:SGTC_2702|Compound:st077768|FD-Score:-3.02|P-value:5.62E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.51|P-value:7.69E-5 ID:SGTC_2953|Compound:9074162|FD-Score:2.96|P-value:7.27E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.70|P-value:3.46E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.56|P-value:6.31E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-3.01|P-value:5.85E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:6.03|P-value:4.26E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:2.94|P-value:7.75E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:34.00|P-value:5.74E-294 ID:SGTC_275|Compound:trichlorophene|FD-Score:2.94|P-value:7.77E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.99|P-value:8.90E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:6.02|P-value:4.61E-11 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.10|P-value:4.22E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-2.95|P-value:7.44E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.16|P-value:3.26E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:16.90|P-value:1.15E-74 ID:SGTC_435|Compound:c-PAF|FD-Score:2.95|P-value:7.43E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.03|P-value:5.51E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.61|P-value:5.03E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.04|P-value:5.37E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.90|P-value:8.79E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.31|P-value:1.83E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.86|P-value:1.62E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.11|P-value:4.73E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:2.97|P-value:6.95E-4 ID:SGTC_1635|Compound:st007035|FD-Score:22.40|P-value:1.16E-128 ID:SGTC_1637|Compound:st007924|FD-Score:-3.79|P-value:2.25E-5 ID:SGTC_1799|Compound:st045822|FD-Score:4.14|P-value:4.28E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-2.93|P-value:7.84E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.94|P-value:5.17E-8 ID:SGTC_2473|Compound:5854593|FD-Score:-2.87|P-value:9.89E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.11|P-value:4.12E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:2.95|P-value:7.52E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.03|P-value:7.23E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:3.00|P-value:6.22E-4 ID:SGTC_2534|Compound:helenine|FD-Score:4.96|P-value:4.77E-8 ID:SGTC_2537|Compound:larixol|FD-Score:7.38|P-value:9.69E-16 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.28|P-value:2.02E-6 ID:SGTC_2702|Compound:st077768|FD-Score:-3.02|P-value:5.62E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.51|P-value:7.69E-5 ID:SGTC_2953|Compound:9074162|FD-Score:2.96|P-value:7.27E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.70|P-value:3.46E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.56|P-value:6.31E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-3.01|P-value:5.85E-4

Top fitness defect scores for YJL166W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 34.00 5.3 µM 5.74E-294 3 5.35E-254
2 SGTC_1635 st007035 22.40 42.4 µM 1.16E-128 16 2.42E-111
3 SGTC_386 1509-0011 16.90 3.1 µM 1.15E-74 15 9.84E-65
4 SGTC_2537 larixol 7.38 68.9 µM 9.69E-16 2 7.78E-14
5 SGTC_134 0269-0018 6.03 6.9 µM 4.26E-11 83 8.11E-10
6 SGTC_335 4077-0256 6.02 27.6 µM 4.61E-11 2 8.70E-10
7 SGTC_2534 helenine 4.96 20.1 µM 4.77E-8 RSC complex & mRNA processing 9 3.56E-7
8 SGTC_1799 st045822 4.14 46.1 µM 4.28E-6 12 1.77E-5
9 SGTC_291 4130-1278 3.99 35.5 µM 8.90E-6 Golgi 16 3.33E-5
10 SGTC_3015 9080845 3.70 49.5 µM 3.46E-5 11 1.09E-4
11 SGTC_2514 salinomycin 3.11 42.7 µM 4.12E-4 96 9.38E-4
12 SGTC_739 1486-1183 3.04 203.0 µM 5.37E-4 46 0.00118
13 SGTC_2533 agelasine 3.00 13.7 µM 6.22E-4 ERG2 99 0.00135
14 SGTC_1499 4480-0877 2.97 67.3 µM 6.95E-4 33 0.00148
15 SGTC_2953 9074162 2.96 66.5 µM 7.27E-4 65 0.00154
16 SGTC_435 c-PAF 2.95 6.7 µM 7.43E-4 101 0.00157
17 SGTC_2522 biochanin a 2.95 4.9 µM 7.52E-4 RNA pol III & RNase P/MRP 45 0.00159
18 SGTC_168 3970-0862 2.94 530.5 µM 7.75E-4 229 0.00163
19 SGTC_275 trichlorophene 2.94 5.7 µM 7.77E-4 mitochondrial stress 308 0.00163
20 SGTC_1859 st055998 2.84 20.0 µM 0.00114 71 0.00229

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.827 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.771 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.762 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.759 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.756 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.749 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.741 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.733 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.733 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.732 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.726 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.722 0 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.718 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.712 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.710 0 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p