YJL167W / ERG20

Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL167W / ERG20

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.02|P-value:6.63E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:6.93|P-value:6.77E-14 ID:SGTC_178|Compound:4092-0806|FD-Score:4.56|P-value:5.85E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:-5.10|P-value:2.16E-8 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.12|P-value:4.51E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.26|P-value:2.35E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:4.06|P-value:7.51E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:-3.03|P-value:5.55E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:8.04|P-value:4.45E-18 ID:SGTC_607|Compound:4491-0986|FD-Score:3.31|P-value:2.16E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.02|P-value:6.60E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-3.25|P-value:2.30E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.70|P-value:4.01E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:-5.25|P-value:8.41E-9 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.32|P-value:2.03E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.21|P-value:3.21E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.05|P-value:7.91E-6 ID:SGTC_1607|Compound:st000305|FD-Score:-3.42|P-value:1.16E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.75|P-value:2.76E-5 ID:SGTC_1623|Compound:st003709|FD-Score:-4.45|P-value:8.61E-7 ID:SGTC_1625|Compound:st003711|FD-Score:-3.61|P-value:5.10E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-3.40|P-value:1.23E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.63|P-value:4.60E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.03|P-value:6.38E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.09|P-value:5.07E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.32|P-value:2.05E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.63|P-value:4.65E-5 ID:SGTC_2073|Compound:5212005|FD-Score:3.83|P-value:2.28E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.19|P-value:3.48E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-2.89|P-value:9.03E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.36|P-value:1.48E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.52|P-value:7.56E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.48|P-value:8.92E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.44|P-value:1.09E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.60|P-value:3.81E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.42|P-value:1.37E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-2.89|P-value:9.11E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:3.51|P-value:9.43E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.03|P-value:6.34E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:5.82|P-value:2.68E-10 ID:SGTC_2954|Compound:9074818|FD-Score:-4.31|P-value:1.80E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-6.54|P-value:1.04E-12 ID:SGTC_3034|Compound:9090421|FD-Score:3.08|P-value:5.27E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.31|P-value:1.84E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.00|P-value:7.08E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.44|P-value:1.26E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.52|P-value:5.01E-16 ID:SGTC_68|Compound:0986-0284|FD-Score:3.02|P-value:6.63E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:6.93|P-value:6.77E-14 ID:SGTC_178|Compound:4092-0806|FD-Score:4.56|P-value:5.85E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:-5.10|P-value:2.16E-8 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.12|P-value:4.51E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.26|P-value:2.35E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:4.06|P-value:7.51E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:-3.03|P-value:5.55E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:8.04|P-value:4.45E-18 ID:SGTC_607|Compound:4491-0986|FD-Score:3.31|P-value:2.16E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.02|P-value:6.60E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-3.25|P-value:2.30E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.70|P-value:4.01E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:-5.25|P-value:8.41E-9 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.32|P-value:2.03E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.21|P-value:3.21E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.05|P-value:7.91E-6 ID:SGTC_1607|Compound:st000305|FD-Score:-3.42|P-value:1.16E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.75|P-value:2.76E-5 ID:SGTC_1623|Compound:st003709|FD-Score:-4.45|P-value:8.61E-7 ID:SGTC_1625|Compound:st003711|FD-Score:-3.61|P-value:5.10E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-3.40|P-value:1.23E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.63|P-value:4.60E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.03|P-value:6.38E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.09|P-value:5.07E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.32|P-value:2.05E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.63|P-value:4.65E-5 ID:SGTC_2073|Compound:5212005|FD-Score:3.83|P-value:2.28E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.19|P-value:3.48E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-2.89|P-value:9.03E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.36|P-value:1.48E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.52|P-value:7.56E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.48|P-value:8.92E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.44|P-value:1.09E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.60|P-value:3.81E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.42|P-value:1.37E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-2.89|P-value:9.11E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:3.51|P-value:9.43E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.03|P-value:6.34E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:5.82|P-value:2.68E-10 ID:SGTC_2954|Compound:9074818|FD-Score:-4.31|P-value:1.80E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-6.54|P-value:1.04E-12 ID:SGTC_3034|Compound:9090421|FD-Score:3.08|P-value:5.27E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.31|P-value:1.84E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.00|P-value:7.08E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.44|P-value:1.26E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.52|P-value:5.01E-16

Top fitness defect scores for YJL167W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_584 0986-0246 8.04 15.4 µM 4.45E-18 heme requiring 3 4.47E-16 0.70
2 SGTC_3304 9125678 7.52 46.1 µM 5.01E-16 15 2.81E-14 0.29
3 SGTC_171 k064-0041 6.93 9.7 µM 6.77E-14 heme requiring 6 2.07E-12 0.62
4 SGTC_2739 tacrine 5.82 100.9 µM 2.68E-10 heme requiring 2 2.97E-9 0.61
5 SGTC_178 4092-0806 4.56 87.5 µM 5.85E-7 ergosterol depletion effects on membrane 17 2.56E-6 0.24
6 SGTC_2510 benzyl isothiocyanate 4.44 8.3 µM 1.09E-6 19 4.44E-6 0.08
7 SGTC_1155 4088-0394 4.32 48.2 µM 2.03E-6 1 7.67E-6 0.25
8 SGTC_521 r062-0005 4.06 13.8 µM 7.51E-6 1 2.42E-5 0.33
9 SGTC_1260 0700-1617 4.05 7.8 µM 7.91E-6 calcium & mitochondrial duress 9 2.54E-5 0.40
10 SGTC_1069 diphenylcyclopropenone 3.97 8.5 µM 1.18E-5 9 3.60E-5 0.10
11 SGTC_2073 5212005 3.83 126.0 µM 2.28E-5 3 6.45E-5 0.01
12 SGTC_1070 indatraline 3.70 8.8 µM 4.01E-5 60S ribosome export 5 1.06E-4 0.04
13 SGTC_2673 kobusone 3.51 100.0 µM 9.43E-5 2 2.26E-4 0.62
14 SGTC_3280 9140961 3.44 49.5 µM 1.26E-4 60S ribosome export 9 2.92E-4 0.07
15 SGTC_2634 4'-methoxyflavone 3.42 100.0 µM 1.37E-4 14 3.15E-4 0.17
16 SGTC_2045 5106652 3.32 78.0 µM 2.05E-4 5 4.49E-4 0.06
17 SGTC_607 4491-0986 3.31 66.8 µM 2.16E-4 heme requiring 11 4.71E-4 0.00
18 SGTC_1183 1254-0324 3.21 198.0 µM 3.21E-4 4 6.69E-4 0.10
19 SGTC_2270 7924575 3.19 90.9 µM 3.48E-4 RPP1 & pyrimidine depletion 14 7.18E-4 0.02
20 SGTC_250 brefeldin a 3.12 552.2 µM 4.51E-4 PDR1 5 9.04E-4 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.291 3.38E-66 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.219 9.45E-38 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.192 3.15E-29 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.176 1.09E-24 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.164 1.00E-21 YLR438C-A LSM3 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.140 3.41E-16 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.138 1.16E-15 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.133 9.02E-15 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.114 4.00E-11 YML085C TUB1 het Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
0.114 4.11E-11 YDR397C NCB2 het Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
0.113 5.22E-11 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.106 8.39E-10 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.105 9.34E-10 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.105 1.08E-9 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.105 1.26E-9 YJL112W MDV1 hom Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication