YJL168C / SET2

Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL168C / SET2

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:-4.06|P-value:2.56E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.23|P-value:4.45E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.85|P-value:1.20E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:4.51|P-value:1.97E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:14.50|P-value:2.37E-49 ID:SGTC_67|Compound:0335-0847|FD-Score:14.20|P-value:3.54E-47 ID:SGTC_86|Compound:0417-1630|FD-Score:11.90|P-value:8.69E-34 ID:SGTC_137|Compound:0438-0332|FD-Score:7.47|P-value:1.35E-14 ID:SGTC_138|Compound:0850-0259|FD-Score:3.89|P-value:3.34E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:6.24|P-value:9.76E-11 ID:SGTC_158|Compound:k038-0087|FD-Score:9.12|P-value:8.42E-21 ID:SGTC_165|Compound:k038-0023|FD-Score:7.51|P-value:9.91E-15 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.29|P-value:9.11E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:5.55|P-value:7.41E-9 ID:SGTC_216|Compound:k038-0035|FD-Score:5.63|P-value:4.59E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.85|P-value:1.17E-9 ID:SGTC_235|Compound:0330-0087|FD-Score:3.56|P-value:1.27E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.87|P-value:3.55E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.34|P-value:4.34E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:3.05|P-value:8.49E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.25|P-value:6.60E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.24|P-value:7.83E-8 ID:SGTC_444|Compound:curcumin|FD-Score:-3.57|P-value:1.91E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.17|P-value:5.55E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.93|P-value:2.80E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.06|P-value:8.14E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.47|P-value:1.81E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.08|P-value:7.56E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.89|P-value:3.28E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:5.28|P-value:3.46E-8 ID:SGTC_837|Compound:0091-0265|FD-Score:3.09|P-value:7.35E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.16|P-value:1.01E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:3.74|P-value:6.33E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:4.95|P-value:2.05E-7 ID:SGTC_994|Compound:3910-0338|FD-Score:5.03|P-value:1.39E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.91|P-value:4.72E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.85|P-value:3.98E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.91|P-value:8.03E-10 ID:SGTC_1529|Compound:apigenin|FD-Score:4.58|P-value:1.36E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.29|P-value:3.61E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.04|P-value:1.72E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.17|P-value:5.48E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-4.12|P-value:1.95E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.16|P-value:8.28E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.88|P-value:3.02E-7 ID:SGTC_1760|Compound:st045453|FD-Score:3.27|P-value:3.89E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.98|P-value:2.22E-5 ID:SGTC_1801|Compound:st050089|FD-Score:3.77|P-value:5.51E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.69|P-value:7.80E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.28|P-value:3.42E-8 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.07|P-value:2.46E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.02|P-value:9.29E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.70|P-value:1.15E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.13|P-value:6.32E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.37|P-value:2.69E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.47|P-value:1.79E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.42|P-value:3.32E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-3.30|P-value:5.10E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.45|P-value:2.00E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.68|P-value:1.25E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.07|P-value:1.52E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:3.33|P-value:3.15E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-6.25|P-value:1.83E-10 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-5.69|P-value:6.04E-9 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.33|P-value:5.49E-11 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.41|P-value:3.16E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:3.59|P-value:1.14E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.18|P-value:5.35E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.34|P-value:4.41E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.22|P-value:7.67E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.70|P-value:7.47E-7 ID:SGTC_3208|Compound:9114115|FD-Score:3.09|P-value:7.37E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.47|P-value:2.79E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.46|P-value:1.89E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.44|P-value:3.05E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-4.06|P-value:2.56E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.23|P-value:4.45E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.85|P-value:1.20E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:4.51|P-value:1.97E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:14.50|P-value:2.37E-49 ID:SGTC_67|Compound:0335-0847|FD-Score:14.20|P-value:3.54E-47 ID:SGTC_86|Compound:0417-1630|FD-Score:11.90|P-value:8.69E-34 ID:SGTC_137|Compound:0438-0332|FD-Score:7.47|P-value:1.35E-14 ID:SGTC_138|Compound:0850-0259|FD-Score:3.89|P-value:3.34E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:6.24|P-value:9.76E-11 ID:SGTC_158|Compound:k038-0087|FD-Score:9.12|P-value:8.42E-21 ID:SGTC_165|Compound:k038-0023|FD-Score:7.51|P-value:9.91E-15 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.29|P-value:9.11E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:5.55|P-value:7.41E-9 ID:SGTC_216|Compound:k038-0035|FD-Score:5.63|P-value:4.59E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.85|P-value:1.17E-9 ID:SGTC_235|Compound:0330-0087|FD-Score:3.56|P-value:1.27E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.87|P-value:3.55E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.34|P-value:4.34E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:3.05|P-value:8.49E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.25|P-value:6.60E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.24|P-value:7.83E-8 ID:SGTC_444|Compound:curcumin|FD-Score:-3.57|P-value:1.91E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.17|P-value:5.55E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.93|P-value:2.80E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.06|P-value:8.14E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.47|P-value:1.81E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.08|P-value:7.56E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.89|P-value:3.28E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:5.28|P-value:3.46E-8 ID:SGTC_837|Compound:0091-0265|FD-Score:3.09|P-value:7.35E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.16|P-value:1.01E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:3.74|P-value:6.33E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:4.95|P-value:2.05E-7 ID:SGTC_994|Compound:3910-0338|FD-Score:5.03|P-value:1.39E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.91|P-value:4.72E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.85|P-value:3.98E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.91|P-value:8.03E-10 ID:SGTC_1529|Compound:apigenin|FD-Score:4.58|P-value:1.36E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.29|P-value:3.61E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.04|P-value:1.72E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.17|P-value:5.48E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-4.12|P-value:1.95E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.16|P-value:8.28E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.88|P-value:3.02E-7 ID:SGTC_1760|Compound:st045453|FD-Score:3.27|P-value:3.89E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.98|P-value:2.22E-5 ID:SGTC_1801|Compound:st050089|FD-Score:3.77|P-value:5.51E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.69|P-value:7.80E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.28|P-value:3.42E-8 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.07|P-value:2.46E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.02|P-value:9.29E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.70|P-value:1.15E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.13|P-value:6.32E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.37|P-value:2.69E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.47|P-value:1.79E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.42|P-value:3.32E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-3.30|P-value:5.10E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.45|P-value:2.00E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.68|P-value:1.25E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.07|P-value:1.52E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:3.33|P-value:3.15E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-6.25|P-value:1.83E-10 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-5.69|P-value:6.04E-9 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.33|P-value:5.49E-11 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.41|P-value:3.16E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:3.59|P-value:1.14E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.18|P-value:5.35E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.34|P-value:4.41E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.22|P-value:7.67E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.70|P-value:7.47E-7 ID:SGTC_3208|Compound:9114115|FD-Score:3.09|P-value:7.37E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.47|P-value:2.79E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.46|P-value:1.89E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.44|P-value:3.05E-4

Top fitness defect scores for YJL168C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 14.50 272.1 µM 2.37E-49 ubiquinone biosynthesis & proteasome 22 5.88E-48
2 SGTC_67 0335-0847 14.20 266.0 µM 3.54E-47 ubiquinone biosynthesis & proteasome 12 7.71E-46
3 SGTC_86 0417-1630 11.90 471.9 µM 8.69E-34 ubiquinone biosynthesis & proteasome 29 8.47E-33
4 SGTC_158 k038-0087 9.12 26.4 µM 8.42E-21 ubiquinone biosynthesis & proteasome 34 3.66E-20
5 SGTC_165 k038-0023 7.51 64.4 µM 9.91E-15 ubiquinone biosynthesis & proteasome 9 2.91E-14
6 SGTC_137 0438-0332 7.47 85.4 µM 1.35E-14 ubiquinone biosynthesis & proteasome 43 3.92E-14
7 SGTC_2582 agaric acid 6.33 100.0 µM 5.49E-11 redox potentiating 146 1.25E-10
8 SGTC_142 0335-0849 6.24 62.7 µM 9.76E-11 ubiquinone biosynthesis & proteasome 55 2.19E-10
9 SGTC_1511 0906-3109 5.91 28.5 µM 8.03E-10 excess fatty acid 12 1.69E-9
10 SGTC_221 trifluoperazine 5.85 10.3 µM 1.17E-9 NEO1-PIK1 126 2.43E-9
11 SGTC_36 0335-0881 5.85 14.2 µM 1.20E-9 ubiquinone biosynthesis & proteasome 67 2.50E-9
12 SGTC_216 k038-0035 5.63 28.4 µM 4.59E-9 ubiquinone biosynthesis & proteasome 27 9.17E-9
13 SGTC_200 k038-0079 5.55 37.5 µM 7.41E-9 ubiquinone biosynthesis & proteasome 32 1.46E-8
14 SGTC_1844 rapamycin 5.28 4.0 nM 3.42E-8 106 6.42E-8
15 SGTC_794 k038-0031 5.28 316.0 µM 3.46E-8 ubiquinone biosynthesis & proteasome 74 6.50E-8
16 SGTC_994 3910-0338 5.03 138.0 µM 1.39E-7 calcium & mitochondrial duress 22 2.50E-7
17 SGTC_934 2950-0684 4.95 338.0 µM 2.05E-7 8 3.63E-7
18 SGTC_1754 st042065 4.88 16.1 µM 3.02E-7 NEO1-PIK1 134 5.30E-7
19 SGTC_3152 9099253 4.70 49.5 µM 7.47E-7 NEO1-PIK1 89 1.27E-6
20 SGTC_1529 apigenin 4.58 74.0 µM 1.36E-6 18 2.28E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.581 4.03E-302 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.570 5.45E-288 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.544 3.98E-258 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.523 4.48E-235 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.515 1.49E-226 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.508 5.27E-220 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.490 2.77E-202 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.486 1.54E-198 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.472 4.49E-186 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.460 2.02E-175 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.455 4.94E-171 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.455 6.40E-171 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.452 1.75E-168 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.451 1.14E-167 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.451 1.15E-167 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress