YJL169W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL169W / YJL169W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.31|P-value:5.92E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:9.23|P-value:1.25E-20 ID:SGTC_39|Compound:0986-0283|FD-Score:3.82|P-value:5.69E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.18|P-value:6.47E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:9.73|P-value:1.06E-22 ID:SGTC_67|Compound:0335-0847|FD-Score:8.41|P-value:1.82E-17 ID:SGTC_86|Compound:0417-1630|FD-Score:9.26|P-value:9.52E-21 ID:SGTC_137|Compound:0438-0332|FD-Score:6.71|P-value:8.31E-12 ID:SGTC_142|Compound:0335-0849|FD-Score:6.22|P-value:2.19E-10 ID:SGTC_158|Compound:k038-0087|FD-Score:8.92|P-value:2.13E-19 ID:SGTC_165|Compound:k038-0023|FD-Score:5.01|P-value:2.32E-7 ID:SGTC_190|Compound:3970-0790|FD-Score:3.23|P-value:5.34E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:4.75|P-value:8.54E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:7.10|P-value:5.43E-13 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.64|P-value:7.30E-9 ID:SGTC_252|Compound:miconazole|FD-Score:-3.20|P-value:8.81E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.96|P-value:2.98E-7 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.86|P-value:4.98E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:4.29|P-value:7.67E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.13|P-value:7.67E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.31|P-value:4.13E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.22|P-value:5.52E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.30|P-value:7.22E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:-5.23|P-value:1.29E-7 ID:SGTC_580|Compound:1123-0028|FD-Score:3.12|P-value:8.00E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.70|P-value:5.14E-9 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.42|P-value:7.04E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:-4.98|P-value:4.73E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:3.61|P-value:1.33E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.44|P-value:1.04E-10 ID:SGTC_768|Compound:0384-0033|FD-Score:3.74|P-value:8.13E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:4.36|P-value:5.58E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.87|P-value:4.73E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.41|P-value:2.78E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.58|P-value:1.47E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.39|P-value:3.06E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.84|P-value:5.41E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.70|P-value:9.29E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.48|P-value:2.21E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:8.32|P-value:3.90E-17 ID:SGTC_1722|Compound:st034304|FD-Score:6.45|P-value:4.84E-11 ID:SGTC_1754|Compound:st042065|FD-Score:5.97|P-value:1.02E-9 ID:SGTC_1800|Compound:st050079|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.73|P-value:8.31E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.60|P-value:1.38E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.72|P-value:8.74E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.82|P-value:9.11E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.16|P-value:7.03E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.18|P-value:6.37E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.06|P-value:9.56E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.21|P-value:5.78E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.28|P-value:6.64E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-4.36|P-value:9.04E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.21|P-value:1.08E-5 ID:SGTC_2479|Compound:5617353|FD-Score:4.31|P-value:7.03E-6 ID:SGTC_2485|Compound:5633444|FD-Score:4.86|P-value:5.07E-7 ID:SGTC_2486|Compound:5283202|FD-Score:-3.18|P-value:9.51E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.51|P-value:2.73E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.50|P-value:2.38E-36 ID:SGTC_2828|Compound:7998861|FD-Score:3.11|P-value:8.14E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-4.14|P-value:2.43E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.88|P-value:4.54E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.79|P-value:7.17E-7 ID:SGTC_3037|Compound:9091026|FD-Score:7.03|P-value:8.75E-13 ID:SGTC_3077|Compound:9117319|FD-Score:-4.57|P-value:3.56E-6 ID:SGTC_3119|Compound:9125183|FD-Score:3.08|P-value:8.98E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.19|P-value:6.23E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.80|P-value:6.31E-5 ID:SGTC_3309|Compound:9129340|FD-Score:4.00|P-value:2.77E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.11|P-value:8.17E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.31|P-value:5.92E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:9.23|P-value:1.25E-20 ID:SGTC_39|Compound:0986-0283|FD-Score:3.82|P-value:5.69E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.18|P-value:6.47E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:9.73|P-value:1.06E-22 ID:SGTC_67|Compound:0335-0847|FD-Score:8.41|P-value:1.82E-17 ID:SGTC_86|Compound:0417-1630|FD-Score:9.26|P-value:9.52E-21 ID:SGTC_137|Compound:0438-0332|FD-Score:6.71|P-value:8.31E-12 ID:SGTC_142|Compound:0335-0849|FD-Score:6.22|P-value:2.19E-10 ID:SGTC_158|Compound:k038-0087|FD-Score:8.92|P-value:2.13E-19 ID:SGTC_165|Compound:k038-0023|FD-Score:5.01|P-value:2.32E-7 ID:SGTC_190|Compound:3970-0790|FD-Score:3.23|P-value:5.34E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:4.75|P-value:8.54E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:7.10|P-value:5.43E-13 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.64|P-value:7.30E-9 ID:SGTC_252|Compound:miconazole|FD-Score:-3.20|P-value:8.81E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.96|P-value:2.98E-7 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.86|P-value:4.98E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:4.29|P-value:7.67E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.13|P-value:7.67E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.31|P-value:4.13E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.22|P-value:5.52E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.30|P-value:7.22E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:-5.23|P-value:1.29E-7 ID:SGTC_580|Compound:1123-0028|FD-Score:3.12|P-value:8.00E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.70|P-value:5.14E-9 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.42|P-value:7.04E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:-4.98|P-value:4.73E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:3.61|P-value:1.33E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.44|P-value:1.04E-10 ID:SGTC_768|Compound:0384-0033|FD-Score:3.74|P-value:8.13E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:4.36|P-value:5.58E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.87|P-value:4.73E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.41|P-value:2.78E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.58|P-value:1.47E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.39|P-value:3.06E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.84|P-value:5.41E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.70|P-value:9.29E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.48|P-value:2.21E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:8.32|P-value:3.90E-17 ID:SGTC_1722|Compound:st034304|FD-Score:6.45|P-value:4.84E-11 ID:SGTC_1754|Compound:st042065|FD-Score:5.97|P-value:1.02E-9 ID:SGTC_1800|Compound:st050079|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.73|P-value:8.31E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.60|P-value:1.38E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.72|P-value:8.74E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.82|P-value:9.11E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.16|P-value:7.03E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.18|P-value:6.37E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.06|P-value:9.56E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.21|P-value:5.78E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.28|P-value:6.64E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-4.36|P-value:9.04E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.21|P-value:1.08E-5 ID:SGTC_2479|Compound:5617353|FD-Score:4.31|P-value:7.03E-6 ID:SGTC_2485|Compound:5633444|FD-Score:4.86|P-value:5.07E-7 ID:SGTC_2486|Compound:5283202|FD-Score:-3.18|P-value:9.51E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.51|P-value:2.73E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.50|P-value:2.38E-36 ID:SGTC_2828|Compound:7998861|FD-Score:3.11|P-value:8.14E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-4.14|P-value:2.43E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.88|P-value:4.54E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.79|P-value:7.17E-7 ID:SGTC_3037|Compound:9091026|FD-Score:7.03|P-value:8.75E-13 ID:SGTC_3077|Compound:9117319|FD-Score:-4.57|P-value:3.56E-6 ID:SGTC_3119|Compound:9125183|FD-Score:3.08|P-value:8.98E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.19|P-value:6.23E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.80|P-value:6.31E-5 ID:SGTC_3309|Compound:9129340|FD-Score:4.00|P-value:2.77E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.11|P-value:8.17E-4

Top fitness defect scores for YJL169W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 12.50 100.0 µM 2.38E-36 redox potentiating 34 2.09E-36
2 SGTC_64 000l-0018 9.73 272.1 µM 1.06E-22 ubiquinone biosynthesis & proteasome 38 1.11E-22
3 SGTC_86 0417-1630 9.26 471.9 µM 9.52E-21 ubiquinone biosynthesis & proteasome 47 1.02E-20
4 SGTC_36 0335-0881 9.23 14.2 µM 1.25E-20 ubiquinone biosynthesis & proteasome 24 1.33E-20
5 SGTC_158 k038-0087 8.92 26.4 µM 2.13E-19 ubiquinone biosynthesis & proteasome 35 2.31E-19
6 SGTC_67 0335-0847 8.41 266.0 µM 1.82E-17 ubiquinone biosynthesis & proteasome 35 2.00E-17
7 SGTC_1718 roemerine 8.32 11.9 µM 3.90E-17 redox potentiating 6 4.30E-17
8 SGTC_216 k038-0035 7.10 28.4 µM 5.43E-13 ubiquinone biosynthesis & proteasome 15 6.19E-13
9 SGTC_3037 9091026 7.03 49.5 µM 8.75E-13 NEO1-PIK1 27 9.98E-13
10 SGTC_137 0438-0332 6.71 85.4 µM 8.31E-12 ubiquinone biosynthesis & proteasome 54 9.54E-12
11 SGTC_1722 st034304 6.45 3.6 µM 4.84E-11 mitochondrial processes 3 5.58E-11
12 SGTC_142 0335-0849 6.22 62.7 µM 2.19E-10 ubiquinone biosynthesis & proteasome 58 2.53E-10
13 SGTC_1754 st042065 5.97 16.1 µM 1.02E-9 NEO1-PIK1 100 1.18E-9
14 SGTC_642 0335-0876 5.70 158.0 µM 5.14E-9 ubiquinone biosynthesis & proteasome 13 5.96E-9
15 SGTC_221 trifluoperazine 5.64 10.3 µM 7.30E-9 NEO1-PIK1 137 8.47E-9
16 SGTC_165 k038-0023 5.01 64.4 µM 2.32E-7 ubiquinone biosynthesis & proteasome 41 2.70E-7
17 SGTC_254 nsc-64875 4.96 3.8 µM 2.98E-7 ergosterol depletion effects on membrane 17 3.46E-7
18 SGTC_2485 5633444 4.86 17.8 µM 5.07E-7 redox potentiating 27 5.89E-7
19 SGTC_2973 9094665 4.79 18.0 µM 7.17E-7 NEO1 17 8.33E-7
20 SGTC_200 k038-0079 4.75 37.5 µM 8.54E-7 ubiquinone biosynthesis & proteasome 43 9.93E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.544 3.98E-258 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.487 1.77E-199 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.465 1.26E-179 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.446 1.57E-163 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.445 2.68E-163 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.443 2.37E-161 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.428 2.51E-149 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.418 2.71E-142 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.410 2.77E-136 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.396 1.71E-126 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.395 6.26E-126 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.394 3.54E-125 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.394 7.67E-125 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.384 1.68E-118 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.382 3.90E-117 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data