YJL171C

GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL171C / YJL171C

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-3.02|P-value:7.81E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.48|P-value:1.31E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.08|P-value:3.96E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:-3.10|P-value:5.77E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.23|P-value:3.56E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:2.86|P-value:8.77E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.19|P-value:4.07E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.05|P-value:7.01E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:2.95|P-value:6.47E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.44|P-value:1.56E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.16|P-value:2.85E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.46|P-value:8.43E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.00|P-value:5.36E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.83|P-value:9.82E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.54|P-value:9.90E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.61|P-value:5.90E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-10.10|P-value:2.22E-27 ID:SGTC_1463|Compound:k081-0032|FD-Score:-9.35|P-value:1.63E-23 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.15|P-value:2.92E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.97|P-value:9.50E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.07|P-value:6.62E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.30|P-value:1.64E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.17|P-value:2.69E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.49|P-value:7.39E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.28|P-value:1.72E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.92|P-value:7.01E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.44|P-value:9.03E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.02|P-value:7.85E-4 ID:SGTC_2914|Compound:7968218|FD-Score:2.93|P-value:6.84E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.48|P-value:1.32E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-5.14|P-value:2.80E-8 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.02|P-value:7.81E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.48|P-value:1.31E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.08|P-value:3.96E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:-3.10|P-value:5.77E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.23|P-value:3.56E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:2.86|P-value:8.77E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.19|P-value:4.07E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.05|P-value:7.01E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:2.95|P-value:6.47E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.44|P-value:1.56E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.16|P-value:2.85E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.46|P-value:8.43E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.00|P-value:5.36E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.83|P-value:9.82E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.54|P-value:9.90E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.61|P-value:5.90E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-10.10|P-value:2.22E-27 ID:SGTC_1463|Compound:k081-0032|FD-Score:-9.35|P-value:1.63E-23 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.15|P-value:2.92E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.97|P-value:9.50E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.07|P-value:6.62E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.30|P-value:1.64E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.17|P-value:2.69E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.49|P-value:7.39E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.28|P-value:1.72E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.92|P-value:7.01E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.44|P-value:9.03E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.02|P-value:7.85E-4 ID:SGTC_2914|Compound:7968218|FD-Score:2.93|P-value:6.84E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.48|P-value:1.32E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-5.14|P-value:2.80E-8

Top fitness defect scores for YJL171C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 3.49 19.9 µM 7.39E-5 redox potentiating 17 2.45E-4
2 SGTC_1295 1013-0063 3.46 9.8 µM 8.43E-5 27 2.75E-4
3 SGTC_2788 5282734 3.44 71.4 µM 9.03E-5 71 2.92E-4
4 SGTC_1679 4130-1276 3.30 6.7 µM 1.64E-4 Golgi 107 4.90E-4
5 SGTC_2557 derrustone 3.28 83.8 µM 1.72E-4 63 5.11E-4
6 SGTC_2255 7941087 3.17 197.4 µM 2.69E-4 63 7.51E-4
7 SGTC_1251 0490-5699 3.16 265.0 µM 2.85E-4 72 7.90E-4
8 SGTC_1541 2',3',6-trimethoxyflavone 3.15 64.0 µM 2.92E-4 37 8.09E-4
9 SGTC_261 5-fluorouridine 3.08 15.4 µM 3.96E-4 exosome 52 0.00105
10 SGTC_1409 3909-8004 3.00 61.9 µM 5.36E-4 79 0.00137
11 SGTC_1105 epirubicin 2.95 18.1 µM 6.47E-4 anthracycline transcription coupled DNA repair 63 0.00161
12 SGTC_2914 7968218 2.93 45.3 µM 6.84E-4 36 0.00169
13 SGTC_2594 a-mangostin 2.92 100.0 µM 7.01E-4 83 0.00173
14 SGTC_342 k048-0088 2.86 23.3 µM 8.77E-4 RSC & ERG11 59 0.00210
15 SGTC_1411 3909-8223 2.83 150.0 µM 9.82E-4 44 0.00231
16 SGTC_2032 5185112 2.77 26.0 µM 0.00123 65 0.00281
17 SGTC_2302 7771753 2.74 200.0 µM 0.00135 127 0.00306
18 SGTC_576 1073-0113 2.74 22.7 µM 0.00136 redox potentiating 176 0.00307
19 SGTC_1227 3909-8010 2.70 46.6 µM 0.00159 96 0.00351
20 SGTC_1106 tegaserod maleate 2.63 11.7 µM 0.00201 117 0.00430

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.523 7.34E-235 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.511 4.20E-221 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.487 6.80E-199 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.486 4.48E-198 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.428 1.30E-149 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.402 1.33E-130 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.398 1.94E-127 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.393 1.51E-124 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.374 8.62E-112 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.362 1.49E-104 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.359 9.42E-103 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.358 3.32E-102 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.356 1.68E-100 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.353 3.63E-99 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.349 2.31E-96 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin