HIPHOP chemogenomics database
YJL175W_d 
Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YJL175W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.231 | 7.40E-42 | YFL034C-B | MOB2 | het | Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p |
| 0.224 | 4.89E-39 | YJL115W | ASF1 | hom | Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition |
| 0.134 | 5.69E-15 | YJL007C_d | YJL007C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.124 | 4.88E-13 | YGL254W | FZF1 | hom | Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress |
| 0.122 | 1.42E-12 | YDR452W | PPN1 | hom | Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress |
| 0.121 | 1.96E-12 | YNL220W | ADE12 | hom | Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence |
| 0.120 | 3.59E-12 | YBL013W | FMT1 | hom | Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate |
| 0.118 | 6.14E-12 | YBL058W | SHP1 | hom | UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate |
| 0.113 | 4.50E-11 | YPR088C | SRP54 | het | Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain |
| 0.103 | 2.04E-9 | YBR196C-A_p | YBR196C-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.103 | 2.32E-9 | YMR040W | YET2 | hom | Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein |
| 0.103 | 2.49E-9 | YFR045W_p | YFR045W_p | hom | Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white |
| 0.102 | 3.29E-9 | YIR010W | DSN1 | het | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation |
| 0.099 | 1.00E-8 | YNL026W | SAM50 | het | Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 |
| 0.094 | 5.37E-8 | YMR265C_p | YMR265C_p | hom | Putative protein of unknown function |