YJL175W_d

Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL175W / YJL175W

Click on Significant Values for Screen Details ID:SGTC_175|Compound:3793-3120|FD-Score:4.41|P-value:1.54E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.01|P-value:1.16E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.18|P-value:3.75E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:2.93|P-value:9.92E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.49|P-value:9.48E-7 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.67|P-value:5.28E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:2.97|P-value:8.70E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.35|P-value:2.00E-6 ID:SGTC_817|Compound:1391-0715|FD-Score:-5.56|P-value:1.94E-9 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.32|P-value:2.32E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:2.94|P-value:9.63E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.02|P-value:7.10E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.53|P-value:9.54E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.99|P-value:1.18E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.00|P-value:7.26E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.52|P-value:9.34E-5 ID:SGTC_1943|Compound:st076331|FD-Score:2.94|P-value:9.47E-4 ID:SGTC_1944|Compound:st076371|FD-Score:6.34|P-value:1.04E-11 ID:SGTC_1950|Compound:st077106|FD-Score:-4.13|P-value:5.82E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.94|P-value:1.50E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.06|P-value:5.86E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.13|P-value:4.67E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.32|P-value:2.11E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-5.53|P-value:2.34E-9 ID:SGTC_2380|Compound:9035439|FD-Score:-4.82|P-value:1.61E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-4.83|P-value:1.48E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.92|P-value:1.01E-7 ID:SGTC_2430|Compound:5571206|FD-Score:-3.08|P-value:5.34E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.33|P-value:2.08E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.87|P-value:1.23E-7 ID:SGTC_2801|Compound:7907800|FD-Score:3.24|P-value:3.09E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.11|P-value:4.87E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.05|P-value:6.03E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.03|P-value:6.43E-4 ID:SGTC_3038|Compound:9091290|FD-Score:2.94|P-value:9.48E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-3.94|P-value:1.49E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.88|P-value:1.97E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.10|P-value:5.25E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.37|P-value:1.73E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.13|P-value:4.83E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-2.97|P-value:7.99E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.02|P-value:1.01E-5 ID:SGTC_3336|Compound:9143619|FD-Score:-3.33|P-value:2.09E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:4.41|P-value:1.54E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.01|P-value:1.16E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.18|P-value:3.75E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:2.93|P-value:9.92E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.49|P-value:9.48E-7 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.67|P-value:5.28E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:2.97|P-value:8.70E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.35|P-value:2.00E-6 ID:SGTC_817|Compound:1391-0715|FD-Score:-5.56|P-value:1.94E-9 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.32|P-value:2.32E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:2.94|P-value:9.63E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.02|P-value:7.10E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.53|P-value:9.54E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.99|P-value:1.18E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.00|P-value:7.26E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.52|P-value:9.34E-5 ID:SGTC_1943|Compound:st076331|FD-Score:2.94|P-value:9.47E-4 ID:SGTC_1944|Compound:st076371|FD-Score:6.34|P-value:1.04E-11 ID:SGTC_1950|Compound:st077106|FD-Score:-4.13|P-value:5.82E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.94|P-value:1.50E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.06|P-value:5.86E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.13|P-value:4.67E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.32|P-value:2.11E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-5.53|P-value:2.34E-9 ID:SGTC_2380|Compound:9035439|FD-Score:-4.82|P-value:1.61E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-4.83|P-value:1.48E-7 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.92|P-value:1.01E-7 ID:SGTC_2430|Compound:5571206|FD-Score:-3.08|P-value:5.34E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.33|P-value:2.08E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.87|P-value:1.23E-7 ID:SGTC_2801|Compound:7907800|FD-Score:3.24|P-value:3.09E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.11|P-value:4.87E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.05|P-value:6.03E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.03|P-value:6.43E-4 ID:SGTC_3038|Compound:9091290|FD-Score:2.94|P-value:9.48E-4 ID:SGTC_3042|Compound:9091578|FD-Score:-3.94|P-value:1.49E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.88|P-value:1.97E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.10|P-value:5.25E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.37|P-value:1.73E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.13|P-value:4.83E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-2.97|P-value:7.99E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.02|P-value:1.01E-5 ID:SGTC_3336|Compound:9143619|FD-Score:-3.33|P-value:2.09E-4

Top fitness defect scores for YJL175W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1944 st076371 6.34 56.9 µM 1.04E-11 2 1.17E-10
2 SGTC_2409 alverine citrate 4.92 64.0 µM 1.01E-7 35 4.37E-7
3 SGTC_175 3793-3120 4.41 23.7 µM 1.54E-6 7 5.06E-6
4 SGTC_178 4092-0806 4.01 87.5 µM 1.16E-5 ergosterol depletion effects on membrane 96 3.09E-5
5 SGTC_415 dibenzyl ketone 3.67 100.0 µM 5.28E-5 16 1.21E-4
6 SGTC_940 3232-1287 3.53 54.8 µM 9.54E-5 NEO1 55 2.06E-4
7 SGTC_1819 st053448 3.50 58.6 µM 1.09E-4 amide catabolism 33 2.33E-4
8 SGTC_2801 7907800 3.24 81.8 µM 3.09E-4 59 5.93E-4
9 SGTC_2118 5526350 3.13 200.0 µM 4.67E-4 39 8.62E-4
10 SGTC_3093 9117344 3.13 49.5 µM 4.83E-4 60S ribosome export 55 8.88E-4
11 SGTC_3062 9077494 3.10 49.5 µM 5.25E-4 mitochondrial response to ROS 71 9.58E-4
12 SGTC_928 2764-0428 3.02 58.7 µM 7.10E-4 cell wall 110 0.00126
13 SGTC_614 0462-0418 2.97 107.0 µM 8.70E-4 85 0.00151
14 SGTC_1943 st076331 2.94 65.2 µM 9.47E-4 55 0.00163
15 SGTC_3038 9091290 2.94 49.5 µM 9.48E-4 62 0.00163
16 SGTC_851 0394-0702 2.94 453.0 µM 9.63E-4 mitochondrial processes 45 0.00166
17 SGTC_302 1094-0063 2.93 18.9 µM 9.92E-4 42 0.00170
18 SGTC_405 ebelactone b 2.90 50.0 µM 0.00111 60 0.00188
19 SGTC_501 nsc-95397 2.89 161.0 µM 0.00114 45 0.00192
20 SGTC_831 k061-1017 2.80 217.0 µM 0.00155 translation 157 0.00254

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.231 7.40E-42 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.224 4.89E-39 YJL115W ASF1 hom Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
0.134 5.69E-15 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.124 4.88E-13 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.122 1.42E-12 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.121 1.96E-12 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.120 3.59E-12 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.118 6.14E-12 YBL058W SHP1 hom UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
0.113 4.50E-11 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.103 2.04E-9 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.103 2.32E-9 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.103 2.49E-9 YFR045W_p YFR045W_p hom Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
0.102 3.29E-9 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.099 1.00E-8 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.094 5.37E-8 YMR265C_p YMR265C_p hom Putative protein of unknown function