YJL181W_p

Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL181W / YJL181W

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-2.97|P-value:4.72E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.57|P-value:2.14E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.37|P-value:5.50E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.79|P-value:6.94E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.28|P-value:1.29E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.43|P-value:1.98E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:3.18|P-value:1.31E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-2.90|P-value:6.34E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:2.74|P-value:7.88E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.46|P-value:3.66E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.67|P-value:1.26E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.42|P-value:2.10E-7 ID:SGTC_1341|Compound:1486-1360|FD-Score:-2.98|P-value:4.49E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-2.81|P-value:8.81E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-2.87|P-value:7.01E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.81|P-value:8.86E-4 ID:SGTC_1755|Compound:st041960|FD-Score:2.98|P-value:3.00E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.04|P-value:2.34E-4 ID:SGTC_1808|Compound:st050063|FD-Score:2.71|P-value:8.95E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.98|P-value:3.02E-4 ID:SGTC_1914|Compound:st062367|FD-Score:2.78|P-value:6.75E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-2.90|P-value:6.16E-4 ID:SGTC_1939|Compound:st074455|FD-Score:5.12|P-value:2.48E-9 ID:SGTC_1947|Compound:st076332|FD-Score:-3.04|P-value:3.58E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.63|P-value:1.61E-5 ID:SGTC_1977|Compound:st070720|FD-Score:2.71|P-value:8.90E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.58|P-value:1.99E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.97|P-value:4.57E-6 ID:SGTC_2397|Compound:5161689|FD-Score:3.95|P-value:3.02E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-2.78|P-value:9.93E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.13|P-value:1.16E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:-4.07|P-value:2.69E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.16|P-value:1.44E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.17|P-value:2.09E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.14|P-value:2.35E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.14|P-value:2.36E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.41|P-value:2.31E-7 ID:SGTC_2821|Compound:7996764|FD-Score:4.47|P-value:1.59E-7 ID:SGTC_2825|Compound:7998094|FD-Score:-4.24|P-value:1.06E-6 ID:SGTC_2827|Compound:7993847|FD-Score:-3.00|P-value:4.15E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.29|P-value:7.77E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.88|P-value:7.16E-6 ID:SGTC_3080|Compound:9117754|FD-Score:2.69|P-value:9.69E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.57|P-value:2.09E-5 ID:SGTC_3127|Compound:9126946|FD-Score:2.96|P-value:3.26E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.46|P-value:3.67E-5 ID:SGTC_3145|Compound:9085516|FD-Score:2.73|P-value:8.31E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.00|P-value:2.77E-4 ID:SGTC_3275|Compound:9138069|FD-Score:2.91|P-value:4.14E-4 ID:SGTC_3337|Compound:9144342|FD-Score:7.32|P-value:3.65E-17 ID:SGTC_3345|Compound:9148410|FD-Score:3.26|P-value:9.12E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.97|P-value:4.72E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.57|P-value:2.14E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.37|P-value:5.50E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.79|P-value:6.94E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.28|P-value:1.29E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.43|P-value:1.98E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:3.18|P-value:1.31E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-2.90|P-value:6.34E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:2.74|P-value:7.88E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.46|P-value:3.66E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.67|P-value:1.26E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.42|P-value:2.10E-7 ID:SGTC_1341|Compound:1486-1360|FD-Score:-2.98|P-value:4.49E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-2.81|P-value:8.81E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-2.87|P-value:7.01E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.81|P-value:8.86E-4 ID:SGTC_1755|Compound:st041960|FD-Score:2.98|P-value:3.00E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.04|P-value:2.34E-4 ID:SGTC_1808|Compound:st050063|FD-Score:2.71|P-value:8.95E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.98|P-value:3.02E-4 ID:SGTC_1914|Compound:st062367|FD-Score:2.78|P-value:6.75E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-2.90|P-value:6.16E-4 ID:SGTC_1939|Compound:st074455|FD-Score:5.12|P-value:2.48E-9 ID:SGTC_1947|Compound:st076332|FD-Score:-3.04|P-value:3.58E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.63|P-value:1.61E-5 ID:SGTC_1977|Compound:st070720|FD-Score:2.71|P-value:8.90E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.58|P-value:1.99E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-3.97|P-value:4.57E-6 ID:SGTC_2397|Compound:5161689|FD-Score:3.95|P-value:3.02E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-2.78|P-value:9.93E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.13|P-value:1.16E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:-4.07|P-value:2.69E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.16|P-value:1.44E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.17|P-value:2.09E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.14|P-value:2.35E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.14|P-value:2.36E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.41|P-value:2.31E-7 ID:SGTC_2821|Compound:7996764|FD-Score:4.47|P-value:1.59E-7 ID:SGTC_2825|Compound:7998094|FD-Score:-4.24|P-value:1.06E-6 ID:SGTC_2827|Compound:7993847|FD-Score:-3.00|P-value:4.15E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.29|P-value:7.77E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.88|P-value:7.16E-6 ID:SGTC_3080|Compound:9117754|FD-Score:2.69|P-value:9.69E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.57|P-value:2.09E-5 ID:SGTC_3127|Compound:9126946|FD-Score:2.96|P-value:3.26E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.46|P-value:3.67E-5 ID:SGTC_3145|Compound:9085516|FD-Score:2.73|P-value:8.31E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.00|P-value:2.77E-4 ID:SGTC_3275|Compound:9138069|FD-Score:2.91|P-value:4.14E-4 ID:SGTC_3337|Compound:9144342|FD-Score:7.32|P-value:3.65E-17 ID:SGTC_3345|Compound:9148410|FD-Score:3.26|P-value:9.12E-5

Top fitness defect scores for YJL181W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3337 9144342 7.32 33.5 µM 3.65E-17 10 1.21E-13
2 SGTC_1939 st074455 5.12 53.6 µM 2.48E-9 10 1.53E-7
3 SGTC_2821 7996764 4.47 71.4 µM 1.59E-7 25 3.92E-6
4 SGTC_459 nigericin 4.43 15.3 µM 1.98E-7 53 4.65E-6
5 SGTC_1181 1222-0449 4.42 220.0 µM 2.10E-7 19 4.87E-6
6 SGTC_2794 7785382 4.41 27.3 µM 2.31E-7 19 5.26E-6
7 SGTC_2749 bexarotene 4.13 57.4 µM 1.16E-6 17 1.85E-5
8 SGTC_2397 5161689 3.95 200.0 µM 3.02E-6 35 3.90E-5
9 SGTC_334 1502-1024 3.79 68.5 µM 6.94E-6 15 7.48E-5
10 SGTC_1128 3448-9350 3.67 235.0 µM 1.26E-5 28 1.19E-4
11 SGTC_1956 st077085 3.63 54.0 µM 1.61E-5 26 1.44E-4
12 SGTC_2003 4023581 3.58 200.0 µM 1.99E-5 cell wall signaling 43 1.71E-4
13 SGTC_3082 9117008 3.57 49.5 µM 2.09E-5 25 1.77E-4
14 SGTC_280 3448-3607 3.57 3.0 µM 2.14E-5 60S ribosome export 18 1.80E-4
15 SGTC_1083 didemethylchlorpromazine sulfoxide 3.46 707.4 nM 3.66E-5 redox potentiating 108 2.75E-4
16 SGTC_3135 9127742 3.46 49.5 µM 3.67E-5 35 2.75E-4
17 SGTC_304 1310-0298 3.37 97.0 µM 5.50E-5 cell wall 86 3.77E-4
18 SGTC_3027 9089541 3.29 49.5 µM 7.77E-5 fatty acid desaturase (OLE1) 43 4.95E-4
19 SGTC_3345 9148410 3.26 3.6 µM 9.12E-5 23 5.60E-4
20 SGTC_626 0214-0009 3.18 33.0 µM 1.31E-4 copper-dependent oxidative stress 51 7.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.37E-15 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.123 7.58E-13 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.110 2.04E-10 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.107 6.18E-10 YLR140W_d YLR140W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
0.103 2.16E-9 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 9.47E-9 YNL089C_d YNL089C_d hom Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
0.097 1.80E-8 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.092 1.03E-7 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.086 5.59E-7 YLR123C_d YLR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
0.083 1.55E-6 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.083 1.70E-6 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.082 1.77E-6 YFL019C_d YFL019C_d hom Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
0.080 3.72E-6 YJL067W_d YJL067W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.88E-6 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.078 5.76E-6 YLR410W VIP1 hom Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1