HIPHOP chemogenomics database

YJL183W / MNN11

Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL183W / MNN11

Click on Significant Values for Screen Details

Top fitness defect scores for YJL183W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2399	5884133	15.00	200.0 µM	1.70E-39	cell wall signaling	5	6.49E-51
2	SGTC_2350	9023895	8.78	38.9 µM	8.00E-15	ergosterol biosynthesis	2	8.50E-19
3	SGTC_911	3456-4043	6.95	236.0 µM	5.97E-10	mitochondrial processes	1	1.82E-12
4	SGTC_119	0121-0043	6.95	24.8 µM	6.01E-10	mitochondrial stress	17	1.83E-12
5	SGTC_878	0828-0289	6.14	13.7 µM	3.82E-8		13	4.00E-10
6	SGTC_1853	st056710	6.09	91.2 µM	4.99E-8	amide catabolism	3	5.66E-10
7	SGTC_2829	7992743	5.81	58.4 µM	1.85E-7		8	3.09E-9
8	SGTC_121	0557-0495	5.73	61.3 µM	2.73E-7	calcium & mitochondrial duress	21	5.10E-9
9	SGTC_1097	itavastatin	5.66	7.2 µM	3.68E-7	azole & statin	8	7.51E-9
10	SGTC_2582	agaric acid	5.48	100.0 µM	8.10E-7	redox potentiating	190	2.09E-8
11	SGTC_18	0111-0177	5.39	500.0 nM	1.22E-6		28	3.55E-8
12	SGTC_2924	9010168	5.06	62.8 µM	4.78E-6	cell wall signaling	15	2.08E-7
13	SGTC_1457	k015-0032	5.00	57.3 µM	6.10E-6		14	2.85E-7
14	SGTC_663	1486-0733	4.85	13.9 µM	1.10E-5	cell wall signaling	33	6.07E-7
15	SGTC_2851	9015922	4.66	71.4 µM	2.32E-5		21	1.60E-6
16	SGTC_989	1501-0895	4.63	10.3 µM	2.57E-5		3	1.82E-6
17	SGTC_976	1348-1067	4.62	47.6 µM	2.66E-5	60S ribosome export	15	1.91E-6
18	SGTC_179	1273-0063	4.62	6.8 µM	2.69E-5		15	1.94E-6
19	SGTC_2460	5552655	4.59	174.2 µM	3.01E-5	amide catabolism	17	2.23E-6
20	SGTC_975	1335-0046	4.48	28.5 µM	4.46E-5	RPP1 & pyrimidine depletion	21	3.71E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.268	3.22E-56	YBR260C	RGD1	hom	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.255	9.27E-51	YAL053W	FLC2	hom	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.229	5.81E-41	YAL056C-A_d	YAL056C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.227	1.37E-40	YNL322C	KRE1	hom	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.207	1.03E-33	YGR196C	FYV8	hom	Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.207	1.16E-33	YNL084C	END3	hom	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.205	4.47E-33	YEL036C	ANP1	hom	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
0.199	3.62E-31	YMR200W	ROT1	het	Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.191	6.70E-29	YAL058W	CNE1	hom	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.176	1.25E-24	YMR238W	DFG5	hom	Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
0.172	1.14E-23	YBR229C	ROT2	hom	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.168	1.05E-22	YGL027C	CWH41	hom	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
0.163	2.25E-21	YDR245W	MNN10	hom	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
0.160	1.24E-20	YJR075W	HOC1	hom	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.143	6.77E-17	YLR332W	MID2	hom	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p