YJL188C_d / BUD19

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL188C / BUD19

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.26|P-value:5.35E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.28|P-value:4.92E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:9.09|P-value:2.82E-19 ID:SGTC_159|Compound:3970-0959|FD-Score:3.71|P-value:1.04E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.29|P-value:4.84E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.68|P-value:2.98E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.20|P-value:6.58E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.11|P-value:8.45E-10 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.40|P-value:7.92E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.76|P-value:2.23E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.28|P-value:5.04E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.10|P-value:4.00E-23 ID:SGTC_808|Compound:0711-0032|FD-Score:3.24|P-value:5.79E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.97|P-value:3.74E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.51|P-value:2.63E-8 ID:SGTC_851|Compound:0394-0702|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.43|P-value:5.33E-6 ID:SGTC_918|Compound:glabranin|FD-Score:-3.53|P-value:5.02E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.39|P-value:3.38E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.02|P-value:3.12E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.46|P-value:6.53E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.61|P-value:2.40E-6 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.67|P-value:1.24E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.16|P-value:7.41E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.56|P-value:9.13E-6 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-5.53|P-value:9.10E-8 ID:SGTC_1657|Compound:st012939|FD-Score:-3.39|P-value:8.02E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.29|P-value:9.74E-6 ID:SGTC_1761|Compound:st044296|FD-Score:3.22|P-value:6.13E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.09|P-value:2.33E-5 ID:SGTC_1840|Compound:st055363|FD-Score:-4.06|P-value:7.24E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.81|P-value:2.00E-8 ID:SGTC_1849|Compound:st056239|FD-Score:5.07|P-value:2.53E-7 ID:SGTC_1969|Compound:st069479|FD-Score:3.14|P-value:8.11E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.91|P-value:5.73E-7 ID:SGTC_2078|Compound:5212016|FD-Score:4.66|P-value:1.87E-6 ID:SGTC_2166|Compound:5933061|FD-Score:-3.63|P-value:3.54E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.37|P-value:3.66E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.19|P-value:1.40E-7 ID:SGTC_2336|Compound:9001819|FD-Score:4.46|P-value:4.65E-6 ID:SGTC_2365|Compound:9042475|FD-Score:3.35|P-value:3.96E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.23|P-value:1.26E-5 ID:SGTC_2388|Compound:9080168|FD-Score:3.28|P-value:4.93E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.25|P-value:5.52E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.37|P-value:2.12E-5 ID:SGTC_2411|Compound:st077133|FD-Score:-5.65|P-value:4.84E-8 ID:SGTC_2455|Compound:5377712|FD-Score:3.41|P-value:3.15E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.29|P-value:8.19E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.63|P-value:2.20E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.53|P-value:3.48E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.35|P-value:9.26E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.19|P-value:6.80E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.13|P-value:8.19E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.37|P-value:5.58E-8 ID:SGTC_2804|Compound:7954240|FD-Score:3.24|P-value:5.67E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.10|P-value:9.26E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.83|P-value:6.63E-5 ID:SGTC_2866|Compound:9034245|FD-Score:4.45|P-value:4.84E-6 ID:SGTC_2921|Compound:7974240|FD-Score:-3.62|P-value:3.77E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-4.32|P-value:2.53E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.68|P-value:1.19E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.51|P-value:2.20E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.12|P-value:5.83E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.19|P-value:6.83E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.17|P-value:7.23E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.23|P-value:5.94E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.46|P-value:2.68E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.90|P-value:6.15E-7 ID:SGTC_3324|Compound:9138759|FD-Score:-8.62|P-value:1.17E-16 ID:SGTC_3327|Compound:9140648|FD-Score:3.21|P-value:6.43E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-5.16|P-value:5.86E-7 ID:SGTC_3334|Compound:9142812|FD-Score:5.07|P-value:2.64E-7 ID:SGTC_31|Compound:0508-1974|FD-Score:3.26|P-value:5.35E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.28|P-value:4.92E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:9.09|P-value:2.82E-19 ID:SGTC_159|Compound:3970-0959|FD-Score:3.71|P-value:1.04E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.29|P-value:4.84E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.68|P-value:2.98E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.20|P-value:6.58E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:6.11|P-value:8.45E-10 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.40|P-value:7.92E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.76|P-value:2.23E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.28|P-value:5.04E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.10|P-value:4.00E-23 ID:SGTC_808|Compound:0711-0032|FD-Score:3.24|P-value:5.79E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.97|P-value:3.74E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.51|P-value:2.63E-8 ID:SGTC_851|Compound:0394-0702|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.43|P-value:5.33E-6 ID:SGTC_918|Compound:glabranin|FD-Score:-3.53|P-value:5.02E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.39|P-value:3.38E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.02|P-value:3.12E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.46|P-value:6.53E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.61|P-value:2.40E-6 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.67|P-value:1.24E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.16|P-value:7.41E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.56|P-value:9.13E-6 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-5.53|P-value:9.10E-8 ID:SGTC_1657|Compound:st012939|FD-Score:-3.39|P-value:8.02E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.29|P-value:9.74E-6 ID:SGTC_1761|Compound:st044296|FD-Score:3.22|P-value:6.13E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.09|P-value:2.33E-5 ID:SGTC_1840|Compound:st055363|FD-Score:-4.06|P-value:7.24E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.81|P-value:2.00E-8 ID:SGTC_1849|Compound:st056239|FD-Score:5.07|P-value:2.53E-7 ID:SGTC_1969|Compound:st069479|FD-Score:3.14|P-value:8.11E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.91|P-value:5.73E-7 ID:SGTC_2078|Compound:5212016|FD-Score:4.66|P-value:1.87E-6 ID:SGTC_2166|Compound:5933061|FD-Score:-3.63|P-value:3.54E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.37|P-value:3.66E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.19|P-value:1.40E-7 ID:SGTC_2336|Compound:9001819|FD-Score:4.46|P-value:4.65E-6 ID:SGTC_2365|Compound:9042475|FD-Score:3.35|P-value:3.96E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.23|P-value:1.26E-5 ID:SGTC_2388|Compound:9080168|FD-Score:3.28|P-value:4.93E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.25|P-value:5.52E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.37|P-value:2.12E-5 ID:SGTC_2411|Compound:st077133|FD-Score:-5.65|P-value:4.84E-8 ID:SGTC_2455|Compound:5377712|FD-Score:3.41|P-value:3.15E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.29|P-value:8.19E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.63|P-value:2.20E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.53|P-value:3.48E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.35|P-value:9.26E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.19|P-value:6.80E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.13|P-value:8.19E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.37|P-value:5.58E-8 ID:SGTC_2804|Compound:7954240|FD-Score:3.24|P-value:5.67E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.10|P-value:9.26E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.83|P-value:6.63E-5 ID:SGTC_2866|Compound:9034245|FD-Score:4.45|P-value:4.84E-6 ID:SGTC_2921|Compound:7974240|FD-Score:-3.62|P-value:3.77E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-4.32|P-value:2.53E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.68|P-value:1.19E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.51|P-value:2.20E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.12|P-value:5.83E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.19|P-value:6.83E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.17|P-value:7.23E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.23|P-value:5.94E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.46|P-value:2.68E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.90|P-value:6.15E-7 ID:SGTC_3324|Compound:9138759|FD-Score:-8.62|P-value:1.17E-16 ID:SGTC_3327|Compound:9140648|FD-Score:3.21|P-value:6.43E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-5.16|P-value:5.86E-7 ID:SGTC_3334|Compound:9142812|FD-Score:5.07|P-value:2.64E-7

Top fitness defect scores for YJL188C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 10.10 155.0 µM 4.00E-23 translation 6 4.34E-24
2 SGTC_118 0083-0097 9.09 135.3 µM 2.82E-19 translation 3 5.10E-20
3 SGTC_625 k213-0058 6.11 121.0 µM 8.45E-10 translation 34 4.94E-10
4 SGTC_832 4083-0019 5.51 164.0 µM 2.63E-8 translation 26 1.82E-8
5 SGTC_2688 kanamycin b 5.37 96.7 µM 5.58E-8 calcium & mitochondrial duress 207 3.99E-8
6 SGTC_2501 sodium tetradecyl sulfate 5.29 13.4 µM 8.19E-8 13 5.96E-8
7 SGTC_2335 9018011 5.19 154.2 µM 1.40E-7 9 1.05E-7
8 SGTC_1849 st056239 5.07 19.2 µM 2.53E-7 RPP1 & pyrimidine depletion 8 1.94E-7
9 SGTC_3334 9142812 5.07 21.9 µM 2.64E-7 12 2.03E-7
10 SGTC_1989 st071868 4.91 50.2 µM 5.73E-7 4 4.56E-7
11 SGTC_3254 9136651 4.90 49.5 µM 6.15E-7 DNA damage response 11 4.91E-7
12 SGTC_2078 5212016 4.66 200.0 µM 1.87E-6 60S ribosome export 5 1.57E-6
13 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.63 92.6 µM 2.20E-6 15 1.86E-6
14 SGTC_1327 1436-0082 4.61 2.2 µM 2.40E-6 11 2.03E-6
15 SGTC_2536 dehydroabietamide 4.53 32.0 µM 3.48E-6 20 2.99E-6
16 SGTC_2336 9001819 4.46 198.7 µM 4.65E-6 heme biosynthesis & mitochondrial translocase 34 4.05E-6
17 SGTC_2866 9034245 4.45 58.4 µM 4.84E-6 3 4.22E-6
18 SGTC_911 3456-4043 4.43 236.0 µM 5.33E-6 mitochondrial processes 19 4.67E-6
19 SGTC_1670 st016595 4.29 4.0 µM 9.74E-6 6 8.74E-6
20 SGTC_2375 9072683 4.23 200.0 µM 1.26E-5 mitochondrial processes 13 1.14E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 2.15E-35 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.211 4.06E-35 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.205 4.41E-33 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.202 3.57E-32 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.198 4.30E-31 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.184 7.60E-27 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.183 1.13E-26 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.180 1.28E-25 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.178 3.05E-25 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.172 7.72E-24 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.172 1.21E-23 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.168 9.28E-23 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.167 2.57E-22 YBR267W REI1 hom Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
0.166 3.18E-22 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.165 7.32E-22 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication