YJL193W_p

Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL193W / YJL193W

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.20|P-value:4.99E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:5.51|P-value:7.04E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:8.53|P-value:7.05E-19 ID:SGTC_44|Compound:0929-0055|FD-Score:-6.35|P-value:2.57E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:15.50|P-value:9.40E-58 ID:SGTC_64|Compound:000l-0018|FD-Score:9.88|P-value:1.09E-24 ID:SGTC_67|Compound:0335-0847|FD-Score:5.40|P-value:1.37E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:10.20|P-value:4.73E-26 ID:SGTC_103|Compound:0844-0104|FD-Score:9.57|P-value:2.81E-23 ID:SGTC_107|Compound:0358-0022|FD-Score:5.87|P-value:7.59E-10 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.06|P-value:1.28E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:21.00|P-value:8.10E-105 ID:SGTC_138|Compound:0850-0259|FD-Score:9.34|P-value:3.14E-22 ID:SGTC_142|Compound:0335-0849|FD-Score:24.90|P-value:4.60E-146 ID:SGTC_150|Compound:3970-0969|FD-Score:3.16|P-value:5.75E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:8.49|P-value:1.08E-18 ID:SGTC_163|Compound:1327-0036|FD-Score:4.20|P-value:7.77E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.08|P-value:7.86E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.04|P-value:1.03E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:6.63|P-value:4.22E-12 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.77|P-value:4.70E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:6.27|P-value:5.25E-11 ID:SGTC_384|Compound:k007-0144|FD-Score:4.83|P-value:3.24E-7 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.08|P-value:1.34E-5 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.28|P-value:5.42E-6 ID:SGTC_406|Compound:estrone|FD-Score:5.58|P-value:4.58E-9 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.33|P-value:3.08E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-4.06|P-value:1.33E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.74|P-value:5.93E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:3.20|P-value:5.05E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.01|P-value:9.89E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.17|P-value:6.04E-14 ID:SGTC_794|Compound:k038-0031|FD-Score:6.22|P-value:7.19E-11 ID:SGTC_819|Compound:1013-0258|FD-Score:3.05|P-value:8.53E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.10|P-value:1.21E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.04|P-value:1.64E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.58|P-value:4.53E-9 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.38|P-value:2.53E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:12.90|P-value:6.21E-41 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.57|P-value:1.28E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.42|P-value:2.20E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-3.37|P-value:2.37E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.48|P-value:1.57E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.06|P-value:7.54E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.37|P-value:2.37E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.52|P-value:1.50E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.32|P-value:4.45E-6 ID:SGTC_1640|Compound:st009078|FD-Score:3.05|P-value:8.51E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.14|P-value:6.14E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.82|P-value:4.33E-5 ID:SGTC_1960|Compound:st011366|FD-Score:-3.21|P-value:4.45E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.59|P-value:1.18E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.63|P-value:9.26E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.32|P-value:3.24E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.47|P-value:1.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.52|P-value:6.59E-9 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.52|P-value:1.42E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.37|P-value:2.39E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.23|P-value:4.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.19|P-value:4.78E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.74|P-value:6.09E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.16|P-value:5.71E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.91|P-value:2.88E-5 ID:SGTC_2803|Compound:7707263|FD-Score:6.51|P-value:9.80E-12 ID:SGTC_2859|Compound:9028643|FD-Score:3.78|P-value:5.03E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.26|P-value:5.84E-6 ID:SGTC_3339|Compound:9145883|FD-Score:3.29|P-value:3.58E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.69|P-value:7.26E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.20|P-value:4.99E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:5.51|P-value:7.04E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:8.53|P-value:7.05E-19 ID:SGTC_44|Compound:0929-0055|FD-Score:-6.35|P-value:2.57E-11 ID:SGTC_58|Compound:0957-0393|FD-Score:15.50|P-value:9.40E-58 ID:SGTC_64|Compound:000l-0018|FD-Score:9.88|P-value:1.09E-24 ID:SGTC_67|Compound:0335-0847|FD-Score:5.40|P-value:1.37E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:10.20|P-value:4.73E-26 ID:SGTC_103|Compound:0844-0104|FD-Score:9.57|P-value:2.81E-23 ID:SGTC_107|Compound:0358-0022|FD-Score:5.87|P-value:7.59E-10 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.06|P-value:1.28E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:21.00|P-value:8.10E-105 ID:SGTC_138|Compound:0850-0259|FD-Score:9.34|P-value:3.14E-22 ID:SGTC_142|Compound:0335-0849|FD-Score:24.90|P-value:4.60E-146 ID:SGTC_150|Compound:3970-0969|FD-Score:3.16|P-value:5.75E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:8.49|P-value:1.08E-18 ID:SGTC_163|Compound:1327-0036|FD-Score:4.20|P-value:7.77E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.08|P-value:7.86E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.04|P-value:1.03E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:6.63|P-value:4.22E-12 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.77|P-value:4.70E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:6.27|P-value:5.25E-11 ID:SGTC_384|Compound:k007-0144|FD-Score:4.83|P-value:3.24E-7 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.08|P-value:1.34E-5 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.28|P-value:5.42E-6 ID:SGTC_406|Compound:estrone|FD-Score:5.58|P-value:4.58E-9 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.33|P-value:3.08E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-4.06|P-value:1.33E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.74|P-value:5.93E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:3.20|P-value:5.05E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.01|P-value:9.89E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.17|P-value:6.04E-14 ID:SGTC_794|Compound:k038-0031|FD-Score:6.22|P-value:7.19E-11 ID:SGTC_819|Compound:1013-0258|FD-Score:3.05|P-value:8.53E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.10|P-value:1.21E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.04|P-value:1.64E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.58|P-value:4.53E-9 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.38|P-value:2.53E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:12.90|P-value:6.21E-41 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.57|P-value:1.28E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.42|P-value:2.20E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-3.37|P-value:2.37E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.48|P-value:1.57E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.06|P-value:7.54E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.37|P-value:2.37E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.52|P-value:1.50E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.32|P-value:4.45E-6 ID:SGTC_1640|Compound:st009078|FD-Score:3.05|P-value:8.51E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.14|P-value:6.14E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.82|P-value:4.33E-5 ID:SGTC_1960|Compound:st011366|FD-Score:-3.21|P-value:4.45E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.59|P-value:1.18E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.63|P-value:9.26E-5 ID:SGTC_2311|Compound:7694451|FD-Score:3.32|P-value:3.24E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.47|P-value:1.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.52|P-value:6.59E-9 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.52|P-value:1.42E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.37|P-value:2.39E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.23|P-value:4.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.19|P-value:4.78E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.74|P-value:6.09E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.16|P-value:5.71E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.91|P-value:2.88E-5 ID:SGTC_2803|Compound:7707263|FD-Score:6.51|P-value:9.80E-12 ID:SGTC_2859|Compound:9028643|FD-Score:3.78|P-value:5.03E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.26|P-value:5.84E-6 ID:SGTC_3339|Compound:9145883|FD-Score:3.29|P-value:3.58E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.69|P-value:7.26E-5

Top fitness defect scores for YJL193W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 24.90 62.7 µM 4.60E-146 ubiquinone biosynthesis & proteasome 4 2.46E-137
2 SGTC_137 0438-0332 21.00 85.4 µM 8.10E-105 ubiquinone biosynthesis & proteasome 4 1.31E-98
3 SGTC_58 0957-0393 15.50 9.0 µM 9.40E-58 cell wall 27 2.08E-54
4 SGTC_1294 1000-1494 12.90 117.0 µM 6.21E-41 7 1.32E-38
5 SGTC_86 0417-1630 10.20 471.9 µM 4.73E-26 ubiquinone biosynthesis & proteasome 37 1.27E-24
6 SGTC_64 000l-0018 9.88 272.1 µM 1.09E-24 ubiquinone biosynthesis & proteasome 37 2.43E-23
7 SGTC_103 0844-0104 9.57 51.8 µM 2.81E-23 ERAD & cell cycle 32 5.16E-22
8 SGTC_138 0850-0259 9.34 40.9 µM 3.14E-22 cell wall 50 4.97E-21
9 SGTC_36 0335-0881 8.53 14.2 µM 7.05E-19 ubiquinone biosynthesis & proteasome 32 7.06E-18
10 SGTC_158 k038-0087 8.49 26.4 µM 1.08E-18 ubiquinone biosynthesis & proteasome 45 1.05E-17
11 SGTC_340 k038-0059 6.63 454.0 µM 4.22E-12 ubiquinone biosynthesis & proteasome 14 1.68E-11
12 SGTC_2803 7707263 6.51 71.4 µM 9.80E-12 3 3.71E-11
13 SGTC_367 0335-0881 6.27 7.1 µM 5.25E-11 ubiquinone biosynthesis & proteasome 23 1.80E-10
14 SGTC_794 k038-0031 6.22 316.0 µM 7.19E-11 ubiquinone biosynthesis & proteasome 52 2.42E-10
15 SGTC_107 0358-0022 5.87 2.7 µM 7.59E-10 SWF1 & branched chain AA biosynthesis 17 2.23E-9
16 SGTC_1161 k007-0610 5.58 110.0 µM 4.53E-9 ERAD & cell cycle 63 1.20E-8
17 SGTC_406 estrone 5.58 100.0 µM 4.58E-9 2 1.21E-8
18 SGTC_2582 agaric acid 5.52 100.0 µM 6.59E-9 redox potentiating 186 1.71E-8
19 SGTC_29 0299-0004 5.51 13.0 µM 7.04E-9 14 1.81E-8
20 SGTC_67 0335-0847 5.40 266.0 µM 1.37E-8 ubiquinone biosynthesis & proteasome 77 3.40E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.710 0 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.678 0 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.672 0 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.663 0 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.629 0 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.611 0 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.611 0 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.586 3.19E-308 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.525 4.09E-237 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.513 2.36E-224 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.464 3.60E-178 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.463 1.26E-177 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.463 3.08E-177 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.462 1.06E-176 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.441 1.04E-159 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p