YJL195C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL195C / YJL195C

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.52|P-value:8.74E-4 ID:SGTC_57|Compound:miconazole|FD-Score:9.48|P-value:1.56E-17 ID:SGTC_70|Compound:0141-0289|FD-Score:3.93|P-value:2.33E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.98|P-value:5.05E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:4.50|P-value:3.04E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.90|P-value:2.58E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.10|P-value:1.33E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-4.59|P-value:2.20E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.88|P-value:2.80E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.60|P-value:2.13E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:41.20|P-value:3.83E-294 ID:SGTC_236|Compound:1509-0011|FD-Score:5.60|P-value:3.16E-7 ID:SGTC_252|Compound:miconazole|FD-Score:12.40|P-value:1.12E-28 ID:SGTC_256|Compound:clotrimazole|FD-Score:13.40|P-value:7.31E-33 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.58|P-value:7.30E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.06|P-value:1.50E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.00|P-value:1.83E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.54|P-value:2.71E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.14|P-value:2.26E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.04|P-value:3.61E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:4.68|P-value:1.53E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:10.80|P-value:4.35E-22 ID:SGTC_584|Compound:0986-0246|FD-Score:4.58|P-value:2.25E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.96|P-value:2.08E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-4.48|P-value:3.40E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.90|P-value:2.57E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.91|P-value:2.54E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:5.43|P-value:6.60E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:-5.07|P-value:3.26E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.92|P-value:2.40E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:5.65|P-value:2.43E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.51|P-value:9.00E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.66|P-value:5.53E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:18.80|P-value:2.11E-63 ID:SGTC_1072|Compound:oxiconazole|FD-Score:11.30|P-value:5.85E-24 ID:SGTC_1084|Compound:voriconazole|FD-Score:11.60|P-value:3.44E-25 ID:SGTC_1152|Compound:3909-8331|FD-Score:5.16|P-value:2.16E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.97|P-value:5.38E-8 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.87|P-value:2.83E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.50|P-value:3.17E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.23|P-value:8.31E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.56|P-value:2.46E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:7.34|P-value:3.29E-11 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.36|P-value:5.13E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.20|P-value:9.08E-5 ID:SGTC_1658|Compound:st012944|FD-Score:5.24|P-value:1.52E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.65|P-value:5.70E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.40|P-value:4.55E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.99|P-value:1.88E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.66|P-value:5.59E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.66|P-value:1.68E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:-4.09|P-value:1.38E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.96|P-value:2.11E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-4.00|P-value:1.86E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.54|P-value:4.08E-7 ID:SGTC_1937|Compound:st074714|FD-Score:4.54|P-value:2.61E-5 ID:SGTC_1961|Compound:st076550|FD-Score:4.19|P-value:9.71E-5 ID:SGTC_2152|Compound:5568786|FD-Score:4.10|P-value:1.31E-4 ID:SGTC_2153|Compound:5569715|FD-Score:4.58|P-value:2.28E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.65|P-value:5.83E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.62|P-value:5.73E-18 ID:SGTC_2325|Compound:6158266|FD-Score:-4.06|P-value:1.50E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-4.55|P-value:2.62E-5 ID:SGTC_2344|Compound:7990960|FD-Score:5.73|P-value:1.70E-7 ID:SGTC_2389|Compound:9091542|FD-Score:4.09|P-value:1.34E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.73|P-value:4.49E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.12|P-value:1.25E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.12|P-value:2.55E-6 ID:SGTC_2459|Compound:5811157|FD-Score:3.57|P-value:7.30E-4 ID:SGTC_2471|Compound:5466956|FD-Score:6.60|P-value:2.11E-9 ID:SGTC_2478|Compound:5763493|FD-Score:4.70|P-value:1.44E-5 ID:SGTC_2482|Compound:5981709|FD-Score:4.12|P-value:1.22E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.48|P-value:9.82E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.18|P-value:1.01E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.01|P-value:1.80E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.73|P-value:4.47E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:6.96E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.52|P-value:4.38E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.88|P-value:2.79E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.90|P-value:6.35E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.99|P-value:1.91E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.30|P-value:1.22E-6 ID:SGTC_2695|Compound:st077686|FD-Score:4.09|P-value:1.37E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:6.90|P-value:4.16E-10 ID:SGTC_2739|Compound:tacrine|FD-Score:3.90|P-value:2.61E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.47|P-value:2.39E-14 ID:SGTC_2804|Compound:7954240|FD-Score:3.65|P-value:5.78E-4 ID:SGTC_2867|Compound:9039098|FD-Score:5.86|P-value:9.03E-8 ID:SGTC_2907|Compound:7721985|FD-Score:3.85|P-value:3.02E-4 ID:SGTC_2925|Compound:9010536|FD-Score:7.02|P-value:2.11E-10 ID:SGTC_2952|Compound:9073731|FD-Score:4.35|P-value:5.45E-5 ID:SGTC_2959|Compound:9079155|FD-Score:-4.23|P-value:8.28E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-6.88|P-value:4.56E-10 ID:SGTC_2972|Compound:9093619|FD-Score:-3.90|P-value:2.62E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.28|P-value:6.96E-5 ID:SGTC_2993|Compound:9054257|FD-Score:10.60|P-value:2.43E-21 ID:SGTC_2994|Compound:9053520|FD-Score:7.02|P-value:2.02E-10 ID:SGTC_2997|Compound:9067075|FD-Score:11.00|P-value:4.96E-23 ID:SGTC_3117|Compound:9124945|FD-Score:-4.24|P-value:8.16E-5 ID:SGTC_3243|Compound:9134147|FD-Score:-5.18|P-value:2.04E-6 ID:SGTC_3270|Compound:9137563|FD-Score:-3.57|P-value:7.53E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.84|P-value:3.20E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.52|P-value:8.74E-4 ID:SGTC_57|Compound:miconazole|FD-Score:9.48|P-value:1.56E-17 ID:SGTC_70|Compound:0141-0289|FD-Score:3.93|P-value:2.33E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.98|P-value:5.05E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:4.50|P-value:3.04E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.90|P-value:2.58E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.10|P-value:1.33E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-4.59|P-value:2.20E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.88|P-value:2.80E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.60|P-value:2.13E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:41.20|P-value:3.83E-294 ID:SGTC_236|Compound:1509-0011|FD-Score:5.60|P-value:3.16E-7 ID:SGTC_252|Compound:miconazole|FD-Score:12.40|P-value:1.12E-28 ID:SGTC_256|Compound:clotrimazole|FD-Score:13.40|P-value:7.31E-33 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.58|P-value:7.30E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.06|P-value:1.50E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.00|P-value:1.83E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.54|P-value:2.71E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.14|P-value:2.26E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.04|P-value:3.61E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:4.68|P-value:1.53E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:10.80|P-value:4.35E-22 ID:SGTC_584|Compound:0986-0246|FD-Score:4.58|P-value:2.25E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.96|P-value:2.08E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-4.48|P-value:3.40E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.90|P-value:2.57E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.91|P-value:2.54E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:5.43|P-value:6.60E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:-5.07|P-value:3.26E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.92|P-value:2.40E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:5.65|P-value:2.43E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.51|P-value:9.00E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.66|P-value:5.53E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:18.80|P-value:2.11E-63 ID:SGTC_1072|Compound:oxiconazole|FD-Score:11.30|P-value:5.85E-24 ID:SGTC_1084|Compound:voriconazole|FD-Score:11.60|P-value:3.44E-25 ID:SGTC_1152|Compound:3909-8331|FD-Score:5.16|P-value:2.16E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.97|P-value:5.38E-8 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.87|P-value:2.83E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.50|P-value:3.17E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.23|P-value:8.31E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.56|P-value:2.46E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:7.34|P-value:3.29E-11 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.36|P-value:5.13E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.20|P-value:9.08E-5 ID:SGTC_1658|Compound:st012944|FD-Score:5.24|P-value:1.52E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.65|P-value:5.70E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.40|P-value:4.55E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.99|P-value:1.88E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.66|P-value:5.59E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.66|P-value:1.68E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:-4.09|P-value:1.38E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.96|P-value:2.11E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-4.00|P-value:1.86E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.54|P-value:4.08E-7 ID:SGTC_1937|Compound:st074714|FD-Score:4.54|P-value:2.61E-5 ID:SGTC_1961|Compound:st076550|FD-Score:4.19|P-value:9.71E-5 ID:SGTC_2152|Compound:5568786|FD-Score:4.10|P-value:1.31E-4 ID:SGTC_2153|Compound:5569715|FD-Score:4.58|P-value:2.28E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.65|P-value:5.83E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.62|P-value:5.73E-18 ID:SGTC_2325|Compound:6158266|FD-Score:-4.06|P-value:1.50E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-4.55|P-value:2.62E-5 ID:SGTC_2344|Compound:7990960|FD-Score:5.73|P-value:1.70E-7 ID:SGTC_2389|Compound:9091542|FD-Score:4.09|P-value:1.34E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.73|P-value:4.49E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.12|P-value:1.25E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.12|P-value:2.55E-6 ID:SGTC_2459|Compound:5811157|FD-Score:3.57|P-value:7.30E-4 ID:SGTC_2471|Compound:5466956|FD-Score:6.60|P-value:2.11E-9 ID:SGTC_2478|Compound:5763493|FD-Score:4.70|P-value:1.44E-5 ID:SGTC_2482|Compound:5981709|FD-Score:4.12|P-value:1.22E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.48|P-value:9.82E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.18|P-value:1.01E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.01|P-value:1.80E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.73|P-value:4.47E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:6.96E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.52|P-value:4.38E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.88|P-value:2.79E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.90|P-value:6.35E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.99|P-value:1.91E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.30|P-value:1.22E-6 ID:SGTC_2695|Compound:st077686|FD-Score:4.09|P-value:1.37E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:6.90|P-value:4.16E-10 ID:SGTC_2739|Compound:tacrine|FD-Score:3.90|P-value:2.61E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:8.47|P-value:2.39E-14 ID:SGTC_2804|Compound:7954240|FD-Score:3.65|P-value:5.78E-4 ID:SGTC_2867|Compound:9039098|FD-Score:5.86|P-value:9.03E-8 ID:SGTC_2907|Compound:7721985|FD-Score:3.85|P-value:3.02E-4 ID:SGTC_2925|Compound:9010536|FD-Score:7.02|P-value:2.11E-10 ID:SGTC_2952|Compound:9073731|FD-Score:4.35|P-value:5.45E-5 ID:SGTC_2959|Compound:9079155|FD-Score:-4.23|P-value:8.28E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-6.88|P-value:4.56E-10 ID:SGTC_2972|Compound:9093619|FD-Score:-3.90|P-value:2.62E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.28|P-value:6.96E-5 ID:SGTC_2993|Compound:9054257|FD-Score:10.60|P-value:2.43E-21 ID:SGTC_2994|Compound:9053520|FD-Score:7.02|P-value:2.02E-10 ID:SGTC_2997|Compound:9067075|FD-Score:11.00|P-value:4.96E-23 ID:SGTC_3117|Compound:9124945|FD-Score:-4.24|P-value:8.16E-5 ID:SGTC_3243|Compound:9134147|FD-Score:-5.18|P-value:2.04E-6 ID:SGTC_3270|Compound:9137563|FD-Score:-3.57|P-value:7.53E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.84|P-value:3.20E-4

Top fitness defect scores for YJL195C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_227 fluconazole 41.20 33.5 µM 3.83E-294 azole & statin 1 0 10.50
2 SGTC_1067 clotrimazole 18.80 1.4 µM 2.11E-63 azole & statin 1 1.76E-79 4.89
3 SGTC_256 clotrimazole 13.40 625.0 nM 7.31E-33 ergosterol depletion effects on membrane 1 5.84E-41 4.41
4 SGTC_252 miconazole 12.40 1.3 nM 1.12E-28 ergosterol depletion effects on membrane 2 1.11E-35 2.07
5 SGTC_1084 voriconazole 11.60 435.0 nM 3.44E-25 azole & statin 1 2.74E-31 3.75
6 SGTC_1072 oxiconazole 11.30 14.9 nM 5.85E-24 ergosterol depletion effects on membrane 3 9.74E-30 1.83
7 SGTC_2997 9067075 11.00 71.4 µM 4.96E-23 unfolded protein response 2 1.44E-28 2.40
8 SGTC_457 grayanotoxin iii 10.80 135.0 µM 4.35E-22 1 2.22E-27 2.41
9 SGTC_2993 9054257 10.60 71.4 µM 2.43E-21 fatty acid desaturase (OLE1) 3 1.94E-26 3.32
10 SGTC_2322 7413319 9.62 38.2 µM 5.73E-18 ERAD & cell cycle 5 3.43E-22 1.81
11 SGTC_57 miconazole 9.48 162.5 nM 1.56E-17 ergosterol depletion effects on membrane 7 1.21E-21 0.17
12 SGTC_2778 tioconazole 8.47 65.1 nM 2.39E-14 ergosterol depletion effects on membrane 7 1.23E-17 0.12
13 SGTC_1469 k284-2957 7.34 126.0 µM 3.29E-11 1 1.09E-13 0.77
14 SGTC_2994 9053520 7.02 71.4 µM 2.02E-10 RPP1 & pyrimidine depletion 1 1.08E-12 1.35
15 SGTC_2925 9010536 7.02 32.5 µM 2.11E-10 azole & statin 1 1.13E-12 2.24
16 SGTC_2735 sertaconazole 6.90 140.0 nM 4.16E-10 plasma membrane duress 1 2.66E-12 2.40
17 SGTC_2471 5466956 6.60 24.8 µM 2.11E-9 mitochondrial processes 8 2.05E-11 0.84
18 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 6.14 8.0 µM 2.26E-8 6 4.00E-10 0.01
19 SGTC_119 0121-0043 5.98 24.8 µM 5.05E-8 mitochondrial stress 7 1.10E-9 0.18
20 SGTC_1282 0886-0010 5.97 32.4 µM 5.38E-8 endomembrane recycling 3 1.19E-9 0.25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 1.11E-68 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.270 3.89E-57 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.242 5.77E-46 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.235 2.37E-43 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.218 1.95E-37 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.211 4.51E-35 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.210 1.09E-34 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.192 3.94E-29 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.191 5.67E-29 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.185 2.46E-27 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.184 5.30E-27 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.181 5.26E-26 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.173 6.91E-24 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.172 1.16E-23 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.170 4.34E-23 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules