YJL207C / LAA1

AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL207C / LAA1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.94|P-value:4.13E-5 ID:SGTC_57|Compound:miconazole|FD-Score:5.64|P-value:8.39E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:3.31|P-value:4.75E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.59|P-value:1.71E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:6.91|P-value:2.51E-12 ID:SGTC_172|Compound:1112-0046|FD-Score:3.35|P-value:4.04E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.06|P-value:2.53E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:6.66|P-value:1.38E-11 ID:SGTC_197|Compound:4544-0043|FD-Score:3.18|P-value:7.39E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.51|P-value:3.28E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:5.04|P-value:2.40E-7 ID:SGTC_254|Compound:nsc-64875|FD-Score:9.06|P-value:6.46E-20 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.79|P-value:7.82E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.67|P-value:1.24E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.87|P-value:1.73E-15 ID:SGTC_278|Compound:4092-0821|FD-Score:3.12|P-value:9.14E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:10.90|P-value:4.07E-28 ID:SGTC_313|Compound:3474-0040|FD-Score:6.47|P-value:4.94E-11 ID:SGTC_320|Compound:4092-0846|FD-Score:7.04|P-value:9.43E-13 ID:SGTC_340|Compound:k038-0059|FD-Score:3.20|P-value:6.91E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:6.56|P-value:2.72E-11 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.63|P-value:1.87E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.52|P-value:3.14E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.36|P-value:3.77E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:9.83|P-value:4.13E-23 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.19|P-value:6.89E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.10|P-value:1.93E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:-4.08|P-value:2.08E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.15|P-value:1.71E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.24|P-value:6.14E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.21|P-value:2.82E-13 ID:SGTC_649|Compound:1123-0311|FD-Score:6.75|P-value:7.65E-12 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.73|P-value:9.00E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.17|P-value:7.40E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.31|P-value:5.53E-8 ID:SGTC_743|Compound:1275-0778|FD-Score:3.69|P-value:1.15E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.99|P-value:1.08E-9 ID:SGTC_788|Compound:1182-0090|FD-Score:9.43|P-value:1.97E-21 ID:SGTC_846|Compound:0335-0850|FD-Score:4.81|P-value:7.80E-7 ID:SGTC_887|Compound:0885-0007|FD-Score:4.23|P-value:1.20E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:6.98|P-value:1.49E-12 ID:SGTC_954|Compound:1189-0853|FD-Score:4.44|P-value:4.63E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.47|P-value:2.27E-8 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.35|P-value:3.83E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.09|P-value:5.61E-10 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.11|P-value:1.63E-7 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.06|P-value:2.33E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.15|P-value:8.21E-4 ID:SGTC_1638|Compound:st008370|FD-Score:7.51|P-value:2.94E-14 ID:SGTC_1672|Compound:st016598|FD-Score:9.69|P-value:1.70E-22 ID:SGTC_1712|Compound:st032288|FD-Score:4.99|P-value:3.01E-7 ID:SGTC_1729|Compound:st035615|FD-Score:-5.27|P-value:6.38E-8 ID:SGTC_1733|Compound:st037357|FD-Score:4.54|P-value:2.84E-6 ID:SGTC_1736|Compound:st036774|FD-Score:-3.72|P-value:9.64E-5 ID:SGTC_1750|Compound:st081859|FD-Score:6.76|P-value:7.12E-12 ID:SGTC_1754|Compound:st042065|FD-Score:7.82|P-value:2.64E-15 ID:SGTC_1760|Compound:st045453|FD-Score:10.90|P-value:4.03E-28 ID:SGTC_1762|Compound:st045503|FD-Score:3.24|P-value:6.17E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.29|P-value:1.57E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.46|P-value:4.24E-6 ID:SGTC_1797|Compound:st048695|FD-Score:5.64|P-value:8.70E-9 ID:SGTC_1801|Compound:st050089|FD-Score:3.85|P-value:6.11E-5 ID:SGTC_1803|Compound:st050068|FD-Score:5.00|P-value:2.84E-7 ID:SGTC_1856|Compound:st057054|FD-Score:-3.58|P-value:1.64E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.53|P-value:2.15E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.92|P-value:4.19E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.56|P-value:1.78E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.13|P-value:1.81E-5 ID:SGTC_2006|Compound:4011487|FD-Score:11.30|P-value:8.28E-30 ID:SGTC_2021|Compound:4019055|FD-Score:3.47|P-value:2.67E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.61|P-value:2.05E-6 ID:SGTC_2036|Compound:5160441|FD-Score:8.06|P-value:3.73E-16 ID:SGTC_2084|Compound:5306078|FD-Score:4.91|P-value:4.71E-7 ID:SGTC_2159|Compound:5658611|FD-Score:3.35|P-value:4.09E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.98|P-value:1.09E-9 ID:SGTC_2257|Compound:7960413|FD-Score:4.05|P-value:2.56E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-4.86|P-value:5.54E-7 ID:SGTC_2277|Compound:7947813|FD-Score:-3.12|P-value:8.76E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.21|P-value:6.76E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.30|P-value:4.58E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.32|P-value:7.93E-6 ID:SGTC_2398|Compound:5228213|FD-Score:4.25|P-value:1.09E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.85|P-value:5.95E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.10|P-value:9.99E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.57|P-value:2.50E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.41|P-value:3.23E-8 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.77|P-value:8.23E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.30|P-value:4.87E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.62|P-value:1.51E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.83|P-value:6.79E-7 ID:SGTC_2790|Compound:5423970|FD-Score:6.50|P-value:4.09E-11 ID:SGTC_2849|Compound:9019321|FD-Score:6.70|P-value:1.04E-11 ID:SGTC_2859|Compound:9028643|FD-Score:3.15|P-value:8.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.96|P-value:3.84E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-4.20|P-value:1.28E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.27|P-value:5.14E-4 ID:SGTC_2948|Compound:9070189|FD-Score:17.00|P-value:2.80E-65 ID:SGTC_2949|Compound:9072542|FD-Score:4.55|P-value:2.69E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.37|P-value:3.53E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.34|P-value:3.95E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.55|P-value:1.86E-4 ID:SGTC_3018|Compound:9082602|FD-Score:6.58|P-value:2.36E-11 ID:SGTC_3074|Compound:9116018|FD-Score:-3.83|P-value:5.97E-5 ID:SGTC_3126|Compound:9127922|FD-Score:12.70|P-value:3.06E-37 ID:SGTC_3152|Compound:9099253|FD-Score:4.74|P-value:1.06E-6 ID:SGTC_3255|Compound:9139072|FD-Score:4.18|P-value:1.47E-5 ID:SGTC_3308|Compound:9128332|FD-Score:14.90|P-value:2.59E-50 ID:SGTC_15|Compound:0266-0086|FD-Score:3.94|P-value:4.13E-5 ID:SGTC_57|Compound:miconazole|FD-Score:5.64|P-value:8.39E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:3.31|P-value:4.75E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.59|P-value:1.71E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:6.91|P-value:2.51E-12 ID:SGTC_172|Compound:1112-0046|FD-Score:3.35|P-value:4.04E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.06|P-value:2.53E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:6.66|P-value:1.38E-11 ID:SGTC_197|Compound:4544-0043|FD-Score:3.18|P-value:7.39E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.51|P-value:3.28E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:5.04|P-value:2.40E-7 ID:SGTC_254|Compound:nsc-64875|FD-Score:9.06|P-value:6.46E-20 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.79|P-value:7.82E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.67|P-value:1.24E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.87|P-value:1.73E-15 ID:SGTC_278|Compound:4092-0821|FD-Score:3.12|P-value:9.14E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:10.90|P-value:4.07E-28 ID:SGTC_313|Compound:3474-0040|FD-Score:6.47|P-value:4.94E-11 ID:SGTC_320|Compound:4092-0846|FD-Score:7.04|P-value:9.43E-13 ID:SGTC_340|Compound:k038-0059|FD-Score:3.20|P-value:6.91E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:6.56|P-value:2.72E-11 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.63|P-value:1.87E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.52|P-value:3.14E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.36|P-value:3.77E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:9.83|P-value:4.13E-23 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.19|P-value:6.89E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.10|P-value:1.93E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:-4.08|P-value:2.08E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.15|P-value:1.71E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.24|P-value:6.14E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.21|P-value:2.82E-13 ID:SGTC_649|Compound:1123-0311|FD-Score:6.75|P-value:7.65E-12 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.73|P-value:9.00E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.17|P-value:7.40E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:5.31|P-value:5.53E-8 ID:SGTC_743|Compound:1275-0778|FD-Score:3.69|P-value:1.15E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.99|P-value:1.08E-9 ID:SGTC_788|Compound:1182-0090|FD-Score:9.43|P-value:1.97E-21 ID:SGTC_846|Compound:0335-0850|FD-Score:4.81|P-value:7.80E-7 ID:SGTC_887|Compound:0885-0007|FD-Score:4.23|P-value:1.20E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:6.98|P-value:1.49E-12 ID:SGTC_954|Compound:1189-0853|FD-Score:4.44|P-value:4.63E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.47|P-value:2.27E-8 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.35|P-value:3.83E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.09|P-value:5.61E-10 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.11|P-value:1.63E-7 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.06|P-value:2.33E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.15|P-value:8.21E-4 ID:SGTC_1638|Compound:st008370|FD-Score:7.51|P-value:2.94E-14 ID:SGTC_1672|Compound:st016598|FD-Score:9.69|P-value:1.70E-22 ID:SGTC_1712|Compound:st032288|FD-Score:4.99|P-value:3.01E-7 ID:SGTC_1729|Compound:st035615|FD-Score:-5.27|P-value:6.38E-8 ID:SGTC_1733|Compound:st037357|FD-Score:4.54|P-value:2.84E-6 ID:SGTC_1736|Compound:st036774|FD-Score:-3.72|P-value:9.64E-5 ID:SGTC_1750|Compound:st081859|FD-Score:6.76|P-value:7.12E-12 ID:SGTC_1754|Compound:st042065|FD-Score:7.82|P-value:2.64E-15 ID:SGTC_1760|Compound:st045453|FD-Score:10.90|P-value:4.03E-28 ID:SGTC_1762|Compound:st045503|FD-Score:3.24|P-value:6.17E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.29|P-value:1.57E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.46|P-value:4.24E-6 ID:SGTC_1797|Compound:st048695|FD-Score:5.64|P-value:8.70E-9 ID:SGTC_1801|Compound:st050089|FD-Score:3.85|P-value:6.11E-5 ID:SGTC_1803|Compound:st050068|FD-Score:5.00|P-value:2.84E-7 ID:SGTC_1856|Compound:st057054|FD-Score:-3.58|P-value:1.64E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.53|P-value:2.15E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.92|P-value:4.19E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.56|P-value:1.78E-4 ID:SGTC_1971|Compound:st069429|FD-Score:4.13|P-value:1.81E-5 ID:SGTC_2006|Compound:4011487|FD-Score:11.30|P-value:8.28E-30 ID:SGTC_2021|Compound:4019055|FD-Score:3.47|P-value:2.67E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.61|P-value:2.05E-6 ID:SGTC_2036|Compound:5160441|FD-Score:8.06|P-value:3.73E-16 ID:SGTC_2084|Compound:5306078|FD-Score:4.91|P-value:4.71E-7 ID:SGTC_2159|Compound:5658611|FD-Score:3.35|P-value:4.09E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.98|P-value:1.09E-9 ID:SGTC_2257|Compound:7960413|FD-Score:4.05|P-value:2.56E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-4.86|P-value:5.54E-7 ID:SGTC_2277|Compound:7947813|FD-Score:-3.12|P-value:8.76E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.21|P-value:6.76E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.30|P-value:4.58E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.32|P-value:7.93E-6 ID:SGTC_2398|Compound:5228213|FD-Score:4.25|P-value:1.09E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.85|P-value:5.95E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.10|P-value:9.99E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.57|P-value:2.50E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.41|P-value:3.23E-8 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.77|P-value:8.23E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.30|P-value:4.87E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.62|P-value:1.51E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.83|P-value:6.79E-7 ID:SGTC_2790|Compound:5423970|FD-Score:6.50|P-value:4.09E-11 ID:SGTC_2849|Compound:9019321|FD-Score:6.70|P-value:1.04E-11 ID:SGTC_2859|Compound:9028643|FD-Score:3.15|P-value:8.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.96|P-value:3.84E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-4.20|P-value:1.28E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.27|P-value:5.14E-4 ID:SGTC_2948|Compound:9070189|FD-Score:17.00|P-value:2.80E-65 ID:SGTC_2949|Compound:9072542|FD-Score:4.55|P-value:2.69E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-3.37|P-value:3.53E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.34|P-value:3.95E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.55|P-value:1.86E-4 ID:SGTC_3018|Compound:9082602|FD-Score:6.58|P-value:2.36E-11 ID:SGTC_3074|Compound:9116018|FD-Score:-3.83|P-value:5.97E-5 ID:SGTC_3126|Compound:9127922|FD-Score:12.70|P-value:3.06E-37 ID:SGTC_3152|Compound:9099253|FD-Score:4.74|P-value:1.06E-6 ID:SGTC_3255|Compound:9139072|FD-Score:4.18|P-value:1.47E-5 ID:SGTC_3308|Compound:9128332|FD-Score:14.90|P-value:2.59E-50

Top fitness defect scores for YJL207C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2948 9070189 17.00 9.4 µM 2.80E-65 plasma membrane duress 3 3.38E-65
2 SGTC_3308 9128332 14.90 17.6 µM 2.59E-50 plasma membrane duress 11 2.94E-50
3 SGTC_3126 9127922 12.70 49.5 µM 3.06E-37 fatty acid desaturase (OLE1) 3 3.31E-37
4 SGTC_2006 4011487 11.30 200.0 µM 8.28E-30 endomembrane recycling 10 8.70E-30
5 SGTC_1760 st045453 10.90 10.4 µM 4.03E-28 NEO1-PIK1 28 4.22E-28
6 SGTC_312 4092-0653 10.90 6.8 µM 4.07E-28 ergosterol depletion effects on membrane 9 4.25E-28
7 SGTC_515 4092-1064 9.83 102.0 µM 4.13E-23 plasma membrane duress 7 4.25E-23
8 SGTC_1672 st016598 9.69 6.5 µM 1.70E-22 endomembrane recycling 10 1.74E-22
9 SGTC_788 1182-0090 9.43 188.0 µM 1.97E-21 endomembrane recycling 15 2.01E-21
10 SGTC_254 nsc-64875 9.06 3.8 µM 6.46E-20 ergosterol depletion effects on membrane 8 6.57E-20
11 SGTC_2036 5160441 8.06 105.0 µM 3.73E-16 NEO1 28 3.75E-16
12 SGTC_262 fenpropimorph 7.87 62.5 µM 1.73E-15 ergosterol depletion effects on membrane 6 1.74E-15
13 SGTC_1754 st042065 7.82 16.1 µM 2.64E-15 NEO1-PIK1 58 2.65E-15
14 SGTC_1638 st008370 7.51 60.6 µM 2.94E-14 ergosterol biosynthesis 7 2.95E-14
15 SGTC_637 1181-0519 7.21 7.3 µM 2.82E-13 fatty acid desaturase (OLE1) 38 2.82E-13
16 SGTC_320 4092-0846 7.04 5.3 µM 9.43E-13 ergosterol depletion effects on membrane 7 9.40E-13
17 SGTC_888 0916-0002 6.98 7.0 µM 1.49E-12 NEO1 18 1.49E-12
18 SGTC_146 3448-8650 6.91 53.1 µM 2.51E-12 NEO1-PIK1 38 2.50E-12
19 SGTC_1750 st081859 6.76 2.4 µM 7.12E-12 endomembrane recycling 92 7.08E-12
20 SGTC_649 1123-0311 6.75 367.0 µM 7.65E-12 endomembrane recycling 21 7.60E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.643 0 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.546 5.79E-259 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.482 4.08E-194 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.481 1.52E-193 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.481 2.52E-193 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.475 8.15E-188 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.465 1.35E-178 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.439 1.60E-157 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.437 5.87E-156 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.415 1.38E-139 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.407 1.06E-133 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.404 8.90E-131 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.400 4.72E-129 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.396 2.35E-126 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.389 4.05E-121 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p