YJL209W / CBP1

Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL209W / CBP1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.09|P-value:8.91E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.57|P-value:1.59E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.36|P-value:5.69E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:3.42|P-value:2.75E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:17.40|P-value:3.26E-68 ID:SGTC_161|Compound:4065-0411|FD-Score:3.84|P-value:5.30E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:6.81|P-value:3.87E-12 ID:SGTC_214|Compound:4373-3496|FD-Score:3.82|P-value:5.83E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:24.30|P-value:2.07E-131 ID:SGTC_310|Compound:1273-0058|FD-Score:4.02|P-value:2.49E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:3.16|P-value:7.11E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:15.10|P-value:2.95E-52 ID:SGTC_522|Compound:1273-0010|FD-Score:3.16|P-value:7.02E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.30|P-value:4.28E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.63|P-value:1.55E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.11|P-value:8.36E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:5.32|P-value:4.34E-8 ID:SGTC_895|Compound:0964-0006|FD-Score:3.25|P-value:5.11E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.84|P-value:6.79E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.43|P-value:3.32E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.12|P-value:8.13E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.36|P-value:3.42E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.17|P-value:6.83E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.24|P-value:5.31E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.68|P-value:1.02E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.25|P-value:5.20E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.30|P-value:4.33E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.43|P-value:2.66E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.37|P-value:3.37E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.20|P-value:5.53E-53 ID:SGTC_1786|Compound:berberine|FD-Score:3.15|P-value:7.25E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.70|P-value:1.16E-11 ID:SGTC_1910|Compound:st062352|FD-Score:-3.91|P-value:4.99E-5 ID:SGTC_1912|Compound:st060209|FD-Score:5.07|P-value:1.64E-7 ID:SGTC_2002|Compound:4023503|FD-Score:4.54|P-value:2.43E-6 ID:SGTC_2043|Compound:5101342|FD-Score:3.11|P-value:8.40E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.45|P-value:3.05E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.43|P-value:3.99E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.90|P-value:4.12E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.21|P-value:5.90E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.44|P-value:2.54E-4 ID:SGTC_2277|Compound:7947813|FD-Score:5.95|P-value:1.11E-9 ID:SGTC_2307|Compound:7538926|FD-Score:4.35|P-value:5.87E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.59|P-value:1.44E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.67|P-value:1.32E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.58|P-value:1.87E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.76|P-value:9.45E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.29|P-value:4.54E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.44|P-value:2.59E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.67|P-value:1.08E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-4.23|P-value:1.30E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-4.29|P-value:9.84E-6 ID:SGTC_2841|Compound:9004761|FD-Score:4.27|P-value:8.28E-6 ID:SGTC_2846|Compound:9008642|FD-Score:4.83|P-value:5.65E-7 ID:SGTC_2861|Compound:9024595|FD-Score:3.17|P-value:6.84E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.91|P-value:4.96E-5 ID:SGTC_2919|Compound:7978188|FD-Score:4.63|P-value:1.52E-6 ID:SGTC_2923|Compound:7992654|FD-Score:-3.58|P-value:1.89E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.11|P-value:8.26E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.20|P-value:7.43E-4 ID:SGTC_3100|Compound:9120536|FD-Score:4.18|P-value:1.26E-5 ID:SGTC_3103|Compound:9120822|FD-Score:5.07|P-value:1.63E-7 ID:SGTC_3106|Compound:9121286|FD-Score:3.74|P-value:7.92E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.63|P-value:1.25E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.09|P-value:8.91E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.60|P-value:1.42E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.57|P-value:1.59E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.36|P-value:5.69E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:3.42|P-value:2.75E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:17.40|P-value:3.26E-68 ID:SGTC_161|Compound:4065-0411|FD-Score:3.84|P-value:5.30E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:6.81|P-value:3.87E-12 ID:SGTC_214|Compound:4373-3496|FD-Score:3.82|P-value:5.83E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:24.30|P-value:2.07E-131 ID:SGTC_310|Compound:1273-0058|FD-Score:4.02|P-value:2.49E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:3.16|P-value:7.11E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:15.10|P-value:2.95E-52 ID:SGTC_522|Compound:1273-0010|FD-Score:3.16|P-value:7.02E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.30|P-value:4.28E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.63|P-value:1.55E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.11|P-value:8.36E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:5.32|P-value:4.34E-8 ID:SGTC_895|Compound:0964-0006|FD-Score:3.25|P-value:5.11E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.84|P-value:6.79E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.43|P-value:3.32E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.12|P-value:8.13E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.36|P-value:3.42E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.17|P-value:6.83E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.24|P-value:5.31E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.68|P-value:1.02E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.25|P-value:5.20E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.30|P-value:4.33E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.43|P-value:2.66E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.37|P-value:3.37E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.20|P-value:5.53E-53 ID:SGTC_1786|Compound:berberine|FD-Score:3.15|P-value:7.25E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.70|P-value:1.16E-11 ID:SGTC_1910|Compound:st062352|FD-Score:-3.91|P-value:4.99E-5 ID:SGTC_1912|Compound:st060209|FD-Score:5.07|P-value:1.64E-7 ID:SGTC_2002|Compound:4023503|FD-Score:4.54|P-value:2.43E-6 ID:SGTC_2043|Compound:5101342|FD-Score:3.11|P-value:8.40E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.45|P-value:3.05E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.43|P-value:3.99E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.90|P-value:4.12E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.21|P-value:5.90E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.44|P-value:2.54E-4 ID:SGTC_2277|Compound:7947813|FD-Score:5.95|P-value:1.11E-9 ID:SGTC_2307|Compound:7538926|FD-Score:4.35|P-value:5.87E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.59|P-value:1.44E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.67|P-value:1.32E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.58|P-value:1.87E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.76|P-value:9.45E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.29|P-value:4.54E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.44|P-value:2.59E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.67|P-value:1.08E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-4.23|P-value:1.30E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-4.29|P-value:9.84E-6 ID:SGTC_2841|Compound:9004761|FD-Score:4.27|P-value:8.28E-6 ID:SGTC_2846|Compound:9008642|FD-Score:4.83|P-value:5.65E-7 ID:SGTC_2861|Compound:9024595|FD-Score:3.17|P-value:6.84E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.91|P-value:4.96E-5 ID:SGTC_2919|Compound:7978188|FD-Score:4.63|P-value:1.52E-6 ID:SGTC_2923|Compound:7992654|FD-Score:-3.58|P-value:1.89E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.11|P-value:8.26E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.20|P-value:7.43E-4 ID:SGTC_3100|Compound:9120536|FD-Score:4.18|P-value:1.26E-5 ID:SGTC_3103|Compound:9120822|FD-Score:5.07|P-value:1.63E-7 ID:SGTC_3106|Compound:9121286|FD-Score:3.74|P-value:7.92E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.63|P-value:1.25E-4

Top fitness defect scores for YJL209W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 24.30 5.3 µM 2.07E-131 36 9.05E-131
2 SGTC_134 0269-0018 17.40 6.9 µM 3.26E-68 12 7.96E-68
3 SGTC_1635 st007035 15.20 42.4 µM 5.53E-53 39 1.16E-52
4 SGTC_386 1509-0011 15.10 3.1 µM 2.95E-52 19 6.13E-52
5 SGTC_168 3970-0862 6.81 530.5 µM 3.87E-12 31 5.01E-12
6 SGTC_2277 7947813 5.95 106.9 µM 1.11E-9 RSC complex & mRNA processing 7 1.38E-9
7 SGTC_893 0958-0369 5.32 48.9 µM 4.34E-8 7 5.26E-8
8 SGTC_3103 9120822 5.07 49.5 µM 1.63E-7 5 1.96E-7
9 SGTC_1912 st060209 5.07 90.8 µM 1.64E-7 16 1.97E-7
10 SGTC_2846 9008642 4.83 19.5 µM 5.65E-7 11 6.72E-7
11 SGTC_2919 7978188 4.63 46.4 µM 1.52E-6 11 1.79E-6
12 SGTC_2002 4023503 4.54 131.0 µM 2.43E-6 mitochondrial processes 18 2.86E-6
13 SGTC_2167 5876490 4.43 200.0 µM 3.99E-6 21 4.67E-6
14 SGTC_87 0100-0052 4.36 35.5 µM 5.69E-6 83 6.64E-6
15 SGTC_2307 7538926 4.35 6.3 µM 5.87E-6 26 6.84E-6
16 SGTC_2841 9004761 4.27 39.0 µM 8.28E-6 amide catabolism 20 9.63E-6
17 SGTC_3100 9120536 4.18 49.5 µM 1.26E-5 7 1.46E-5
18 SGTC_310 1273-0058 4.02 1.1 µM 2.49E-5 mitochondrial stress 241 2.87E-5
19 SGTC_2255 7941087 3.90 197.4 µM 4.12E-5 31 4.72E-5
20 SGTC_161 4065-0411 3.84 162.2 µM 5.30E-5 68 6.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.683 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.673 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.667 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.662 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.655 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.648 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.635 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.633 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.632 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.625 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.624 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.617 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.616 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.613 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.613 0 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p