YJL213W

Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL213W / YJL213W

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.32|P-value:2.11E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.06|P-value:5.68E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.66|P-value:5.17E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.52|P-value:9.23E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.18|P-value:3.60E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.40|P-value:1.51E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.47|P-value:1.12E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.20|P-value:3.32E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.12|P-value:5.98E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:3.83|P-value:2.42E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:4.31|P-value:2.36E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:4.01|P-value:1.02E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.18|P-value:4.47E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.27|P-value:2.59E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.56|P-value:7.58E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:2.97|P-value:8.06E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.61|P-value:6.20E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.75|P-value:3.38E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.08|P-value:5.31E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.34|P-value:1.92E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.99|P-value:7.46E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.19|P-value:3.48E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:6.42|P-value:4.45E-12 ID:SGTC_2134|Compound:5324836|FD-Score:-3.71|P-value:4.06E-5 ID:SGTC_2159|Compound:5658611|FD-Score:-3.56|P-value:7.72E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.24|P-value:2.92E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-2.92|P-value:9.37E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_2431|Compound:5490079|FD-Score:5.75|P-value:5.12E-10 ID:SGTC_2433|Compound:5607874|FD-Score:3.22|P-value:3.19E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.31|P-value:2.33E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.17|P-value:3.75E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.10|P-value:4.95E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.12|P-value:4.55E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.07|P-value:5.42E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.09|P-value:5.26E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-2.91|P-value:9.90E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.17|P-value:3.76E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.18|P-value:3.63E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.49|P-value:9.10E-7 ID:SGTC_3216|Compound:9129716|FD-Score:3.57|P-value:7.37E-5 ID:SGTC_3292|Compound:9120825|FD-Score:-3.19|P-value:3.49E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.17|P-value:3.86E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.12|P-value:4.60E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.32|P-value:2.11E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.06|P-value:5.68E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.66|P-value:5.17E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.52|P-value:9.23E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.18|P-value:3.60E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.40|P-value:1.51E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.47|P-value:1.12E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.20|P-value:3.32E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.12|P-value:5.98E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:3.83|P-value:2.42E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:4.31|P-value:2.36E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:4.01|P-value:1.02E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.18|P-value:4.47E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.27|P-value:2.59E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.56|P-value:7.58E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:2.97|P-value:8.06E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.61|P-value:6.20E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.75|P-value:3.38E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.08|P-value:5.31E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.34|P-value:1.92E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-2.99|P-value:7.46E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.19|P-value:3.48E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:6.42|P-value:4.45E-12 ID:SGTC_2134|Compound:5324836|FD-Score:-3.71|P-value:4.06E-5 ID:SGTC_2159|Compound:5658611|FD-Score:-3.56|P-value:7.72E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.24|P-value:2.92E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-2.92|P-value:9.37E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_2431|Compound:5490079|FD-Score:5.75|P-value:5.12E-10 ID:SGTC_2433|Compound:5607874|FD-Score:3.22|P-value:3.19E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.31|P-value:2.33E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.17|P-value:3.75E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.10|P-value:4.95E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.12|P-value:4.55E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.07|P-value:5.42E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.09|P-value:5.26E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-2.91|P-value:9.90E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-3.17|P-value:3.76E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.18|P-value:3.63E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.49|P-value:9.10E-7 ID:SGTC_3216|Compound:9129716|FD-Score:3.57|P-value:7.37E-5 ID:SGTC_3292|Compound:9120825|FD-Score:-3.19|P-value:3.49E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.17|P-value:3.86E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.12|P-value:4.60E-4

Top fitness defect scores for YJL213W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1876 myriocin 6.42 605.0 nM 4.45E-12 12 6.70E-11
2 SGTC_2431 5490079 5.75 200.0 µM 5.12E-10 9 4.53E-9
3 SGTC_3058 9093861 4.49 49.5 µM 9.10E-7 10 3.51E-6
4 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.31 66.7 µM 2.33E-6 11 8.11E-6
5 SGTC_910 3454-3003 4.31 490.0 µM 2.36E-6 11 8.20E-6
6 SGTC_851 0394-0702 4.12 453.0 µM 5.98E-6 mitochondrial processes 10 1.88E-5
7 SGTC_919 tnp00227 4.01 403.6 nM 1.02E-5 RNA pol III & RNase P/MRP 33 3.02E-5
8 SGTC_892 0929-0076 3.83 29.0 µM 2.42E-5 TRP & mitochondrial translation 43 6.53E-5
9 SGTC_1445 4239-0156 3.75 97.7 µM 3.38E-5 34 8.79E-5
10 SGTC_154 3389-1638 3.66 511.1 µM 5.17E-5 33 1.28E-4
11 SGTC_1164 k060-0068 3.61 93.7 µM 6.20E-5 40 1.51E-4
12 SGTC_3216 9129716 3.57 49.5 µM 7.37E-5 RPP1 & pyrimidine depletion 36 1.76E-4
13 SGTC_541 4513-1321 3.52 94.0 µM 9.23E-5 33 2.15E-4
14 SGTC_826 1683-5028 3.40 118.0 µM 1.51E-4 30 3.34E-4
15 SGTC_2285 7945142 3.38 200.0 µM 1.64E-4 39 3.59E-4
16 SGTC_22 0964-0034 3.32 14.5 µM 2.11E-4 unfolded protein response 70 4.50E-4
17 SGTC_1045 1348-1485 3.27 165.0 µM 2.59E-4 66 5.40E-4
18 SGTC_2241 6772625 3.24 37.8 µM 2.92E-4 50 6.01E-4
19 SGTC_2433 5607874 3.22 27.8 µM 3.19E-4 53 6.50E-4
20 SGTC_1837 st055472 3.19 66.5 µM 3.48E-4 44 7.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.259 1.08E-52 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.175 1.82E-24 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.149 3.29E-18 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.148 7.57E-18 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.141 2.29E-16 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.116 1.83E-11 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.100 5.77E-9 YER150W SPI1 hom GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
0.093 7.96E-8 YHR059W FYV4 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.089 2.31E-7 YDR333C RQC1 hom Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.085 8.66E-7 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.085 9.45E-7 YER130C_p YER130C_p hom Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress
0.082 1.87E-6 YFR049W YMR31 hom Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
0.081 2.35E-6 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.079 5.18E-6 YHR046C INM1 hom Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
0.078 5.48E-6 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data