YJR001W / AVT1

Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR001W / AVT1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:-3.82|P-value:4.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.50|P-value:1.09E-8 ID:SGTC_205|Compound:1486-1330|FD-Score:4.79|P-value:1.92E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.63|P-value:9.01E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.05|P-value:2.46E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.81|P-value:5.24E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.87|P-value:4.39E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.92|P-value:3.78E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.78|P-value:5.73E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:4.55|P-value:4.48E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.63|P-value:8.52E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.61|P-value:9.01E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:5.59|P-value:7.44E-7 ID:SGTC_487|Compound:nimodipine|FD-Score:3.84|P-value:4.89E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:6.09|P-value:8.11E-8 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.15|P-value:1.80E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:4.02|P-value:2.77E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.74|P-value:6.48E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:4.99|P-value:8.98E-6 ID:SGTC_773|Compound:4358-1457|FD-Score:11.00|P-value:1.29E-21 ID:SGTC_939|Compound:1165-0479|FD-Score:4.32|P-value:1.03E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.54|P-value:4.73E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.86|P-value:4.46E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.81|P-value:5.21E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.00|P-value:2.90E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.62|P-value:9.36E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.70|P-value:7.30E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.70|P-value:7.45E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.66|P-value:2.80E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.76|P-value:5.69E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.84|P-value:4.82E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.46|P-value:6.34E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:-4.21|P-value:1.35E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.71|P-value:4.48E-7 ID:SGTC_1626|Compound:st003712|FD-Score:3.70|P-value:7.33E-4 ID:SGTC_1637|Compound:st007924|FD-Score:5.52|P-value:1.02E-6 ID:SGTC_1732|Compound:st034308|FD-Score:5.72|P-value:4.31E-7 ID:SGTC_1832|Compound:st054113|FD-Score:-4.32|P-value:9.38E-5 ID:SGTC_1833|Compound:st055984|FD-Score:7.02|P-value:7.69E-10 ID:SGTC_1834|Compound:st055981|FD-Score:-5.37|P-value:1.72E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:9.98|P-value:4.24E-18 ID:SGTC_1985|Compound:st071382|FD-Score:4.76|P-value:2.15E-5 ID:SGTC_1988|Compound:st071872|FD-Score:4.24|P-value:1.33E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.88|P-value:4.27E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.61|P-value:3.32E-5 ID:SGTC_2024|Compound:5144227|FD-Score:5.20|P-value:3.77E-6 ID:SGTC_2165|Compound:5727197|FD-Score:4.99|P-value:8.83E-6 ID:SGTC_2180|Compound:6301957|FD-Score:3.82|P-value:5.19E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-4.46|P-value:5.80E-5 ID:SGTC_2272|Compound:7805186|FD-Score:3.91|P-value:3.82E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.06|P-value:2.26E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.15|P-value:1.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.82|P-value:5.09E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.64|P-value:8.90E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.75|P-value:5.88E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.13|P-value:1.90E-4 ID:SGTC_2883|Compound:9059145|FD-Score:4.75|P-value:2.16E-5 ID:SGTC_2891|Compound:9063876|FD-Score:-4.03|P-value:2.47E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.66|P-value:8.21E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.79|P-value:1.88E-5 ID:SGTC_3165|Compound:9101544|FD-Score:-3.67|P-value:7.44E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.75|P-value:6.37E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.55|P-value:4.48E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.82|P-value:4.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.50|P-value:1.09E-8 ID:SGTC_205|Compound:1486-1330|FD-Score:4.79|P-value:1.92E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.63|P-value:9.01E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.05|P-value:2.46E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.81|P-value:5.24E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.87|P-value:4.39E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.92|P-value:3.78E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.78|P-value:5.73E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:4.55|P-value:4.48E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.63|P-value:8.52E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.61|P-value:9.01E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:5.59|P-value:7.44E-7 ID:SGTC_487|Compound:nimodipine|FD-Score:3.84|P-value:4.89E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:6.09|P-value:8.11E-8 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.15|P-value:1.80E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:4.02|P-value:2.77E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.74|P-value:6.48E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:4.99|P-value:8.98E-6 ID:SGTC_773|Compound:4358-1457|FD-Score:11.00|P-value:1.29E-21 ID:SGTC_939|Compound:1165-0479|FD-Score:4.32|P-value:1.03E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.54|P-value:4.73E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.86|P-value:4.46E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.81|P-value:5.21E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.00|P-value:2.90E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.62|P-value:9.36E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.70|P-value:7.30E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.70|P-value:7.45E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.66|P-value:2.80E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.76|P-value:5.69E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.84|P-value:4.82E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.46|P-value:6.34E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:-4.21|P-value:1.35E-4 ID:SGTC_1625|Compound:st003711|FD-Score:5.71|P-value:4.48E-7 ID:SGTC_1626|Compound:st003712|FD-Score:3.70|P-value:7.33E-4 ID:SGTC_1637|Compound:st007924|FD-Score:5.52|P-value:1.02E-6 ID:SGTC_1732|Compound:st034308|FD-Score:5.72|P-value:4.31E-7 ID:SGTC_1832|Compound:st054113|FD-Score:-4.32|P-value:9.38E-5 ID:SGTC_1833|Compound:st055984|FD-Score:7.02|P-value:7.69E-10 ID:SGTC_1834|Compound:st055981|FD-Score:-5.37|P-value:1.72E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:9.98|P-value:4.24E-18 ID:SGTC_1985|Compound:st071382|FD-Score:4.76|P-value:2.15E-5 ID:SGTC_1988|Compound:st071872|FD-Score:4.24|P-value:1.33E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.88|P-value:4.27E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.61|P-value:3.32E-5 ID:SGTC_2024|Compound:5144227|FD-Score:5.20|P-value:3.77E-6 ID:SGTC_2165|Compound:5727197|FD-Score:4.99|P-value:8.83E-6 ID:SGTC_2180|Compound:6301957|FD-Score:3.82|P-value:5.19E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-4.46|P-value:5.80E-5 ID:SGTC_2272|Compound:7805186|FD-Score:3.91|P-value:3.82E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.06|P-value:2.26E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.15|P-value:1.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.82|P-value:5.09E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.64|P-value:8.90E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.75|P-value:5.88E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.13|P-value:1.90E-4 ID:SGTC_2883|Compound:9059145|FD-Score:4.75|P-value:2.16E-5 ID:SGTC_2891|Compound:9063876|FD-Score:-4.03|P-value:2.47E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.66|P-value:8.21E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.79|P-value:1.88E-5 ID:SGTC_3165|Compound:9101544|FD-Score:-3.67|P-value:7.44E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.75|P-value:6.37E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.55|P-value:4.48E-5

Top fitness defect scores for YJR001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_773 4358-1457 11.00 44.6 µM 1.29E-21 1 1.84E-28
2 SGTC_1926 methyl fluorone black 9.98 53.6 µM 4.24E-18 DNA intercalators 3 9.63E-24
3 SGTC_1833 st055984 7.02 71.0 µM 7.69E-10 2 1.14E-12
4 SGTC_58 0957-0393 6.50 9.0 µM 1.09E-8 cell wall 182 3.95E-11
5 SGTC_495 decylubiquinone 6.09 155.0 µM 8.11E-8 copper-dependent oxidative stress 4 5.78E-10
6 SGTC_1732 st034308 5.72 51.8 µM 4.31E-7 4 5.38E-9
7 SGTC_1625 st003711 5.71 30.1 µM 4.48E-7 calcium & mitochondrial duress 12 5.66E-9
8 SGTC_373 0844-0104 5.59 25.9 µM 7.44E-7 ERAD & cell cycle 24 1.12E-8
9 SGTC_1637 st007924 5.52 17.4 µM 1.02E-6 5 1.70E-8
10 SGTC_2024 5144227 5.20 134.0 µM 3.77E-6 13 9.72E-8
11 SGTC_2165 5727197 4.99 32.1 µM 8.83E-6 18 3.02E-7
12 SGTC_696 1560-0013 4.99 611.0 µM 8.98E-6 10 3.09E-7
13 SGTC_3031 9088762 4.79 49.5 µM 1.88E-5 7 8.26E-7
14 SGTC_205 1486-1330 4.79 71.9 µM 1.92E-5 9 8.49E-7
15 SGTC_1985 st071382 4.76 65.5 µM 2.15E-5 9 9.86E-7
16 SGTC_2883 9059145 4.75 45.5 µM 2.16E-5 4 9.98E-7
17 SGTC_335 4077-0256 4.55 27.6 µM 4.48E-5 9 2.63E-6
18 SGTC_3259 9138485 4.55 49.5 µM 4.48E-5 5 2.63E-6
19 SGTC_943 3253-1379 4.54 105.0 µM 4.73E-5 16 2.82E-6
20 SGTC_1493 4348-0038 4.46 111.0 µM 6.34E-5 RSC complex & mRNA processing 14 4.17E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 6.35E-17 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.143 1.13E-16 YLR271W_p YLR271W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.139 6.27E-16 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.135 5.62E-15 YGL220W FRA2 hom Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.129 8.39E-14 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.127 1.75E-13 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.119 5.70E-12 YPL141C FRK1 hom Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication
0.115 2.69E-11 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.115 2.79E-11 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.115 2.94E-11 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.114 4.84E-11 YOL035C_d YOL035C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.113 5.21E-11 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.113 6.37E-11 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.112 9.36E-11 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.112 1.01E-10 YML093W UTP14 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit