YJR002W / MPP10

Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR002W / MPP10

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.21|P-value:2.84E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.22|P-value:2.72E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.11|P-value:8.23E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.92|P-value:1.43E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.20|P-value:5.84E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.38|P-value:1.50E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.00|P-value:9.87E-6 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.64|P-value:1.07E-4 ID:SGTC_276|Compound:colchicine|FD-Score:-3.16|P-value:6.79E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.12|P-value:7.97E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.15|P-value:3.62E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.97|P-value:2.63E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:2.99|P-value:6.58E-4 ID:SGTC_447|Compound:ml7|FD-Score:-3.47|P-value:2.09E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.10|P-value:4.39E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.56|P-value:7.02E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.70|P-value:3.78E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.72|P-value:7.65E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.46|P-value:1.05E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.67|P-value:4.32E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.32|P-value:3.76E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.28|P-value:2.59E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.69|P-value:4.04E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.35|P-value:3.33E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.41|P-value:3.30E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.02|P-value:5.97E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.13|P-value:5.27E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:2.89|P-value:9.46E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:2.88|P-value:9.65E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.56|P-value:1.49E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.11|P-value:4.26E-4 ID:SGTC_1796|Compound:st049173|FD-Score:2.99|P-value:6.66E-4 ID:SGTC_1832|Compound:st054113|FD-Score:3.16|P-value:3.44E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.41|P-value:1.32E-6 ID:SGTC_1934|Compound:st074720|FD-Score:-3.66|P-value:9.88E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.45|P-value:1.10E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.03|P-value:8.55E-6 ID:SGTC_2116|Compound:5511452|FD-Score:3.13|P-value:3.88E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.70|P-value:8.26E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.19|P-value:6.15E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.69|P-value:4.04E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.29|P-value:5.89E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.16|P-value:6.85E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.43|P-value:1.21E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.98|P-value:2.51E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.23|P-value:2.63E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.60|P-value:1.24E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.21|P-value:2.93E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-5.33|P-value:2.33E-8 ID:SGTC_23|Compound:0213-0011|FD-Score:3.21|P-value:2.84E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.22|P-value:2.72E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.11|P-value:8.23E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.92|P-value:1.43E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.20|P-value:5.84E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.38|P-value:1.50E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.00|P-value:9.87E-6 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.64|P-value:1.07E-4 ID:SGTC_276|Compound:colchicine|FD-Score:-3.16|P-value:6.79E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.12|P-value:7.97E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.15|P-value:3.62E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.97|P-value:2.63E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:2.99|P-value:6.58E-4 ID:SGTC_447|Compound:ml7|FD-Score:-3.47|P-value:2.09E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.10|P-value:4.39E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.56|P-value:7.02E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:3.70|P-value:3.78E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.72|P-value:7.65E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.46|P-value:1.05E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.67|P-value:4.32E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.32|P-value:3.76E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.28|P-value:2.59E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.69|P-value:4.04E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.35|P-value:3.33E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.41|P-value:3.30E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.02|P-value:5.97E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.13|P-value:5.27E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:2.89|P-value:9.46E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:2.88|P-value:9.65E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.56|P-value:1.49E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.11|P-value:4.26E-4 ID:SGTC_1796|Compound:st049173|FD-Score:2.99|P-value:6.66E-4 ID:SGTC_1832|Compound:st054113|FD-Score:3.16|P-value:3.44E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.41|P-value:1.32E-6 ID:SGTC_1934|Compound:st074720|FD-Score:-3.66|P-value:9.88E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.45|P-value:1.10E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.03|P-value:8.55E-6 ID:SGTC_2116|Compound:5511452|FD-Score:3.13|P-value:3.88E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.70|P-value:8.26E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.19|P-value:6.15E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.69|P-value:4.04E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.29|P-value:5.89E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.16|P-value:6.85E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.43|P-value:1.21E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.98|P-value:2.51E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.23|P-value:2.63E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.60|P-value:1.24E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.21|P-value:2.93E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-5.33|P-value:2.33E-8

Top fitness defect scores for YJR002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1932 st074806 4.41 40.9 µM 1.32E-6 7 5.08E-6 0.67
2 SGTC_1326 1431-2094 4.28 10.8 µM 2.59E-6 tubulin folding & SWR complex 4 9.38E-6 0.40
3 SGTC_1421 4029-0249 4.13 71.4 µM 5.27E-6 2 1.78E-5 0.27
4 SGTC_1948 st076329 4.03 66.6 µM 8.55E-6 3 2.76E-5 0.35
5 SGTC_270 tamoxifen 4.00 5.5 µM 9.87E-6 NEO1 5 3.15E-5 0.06
6 SGTC_96 0929-0093 3.92 37.3 µM 1.43E-5 calcium & mitochondrial duress 5 4.40E-5 0.33
7 SGTC_937 3122-0005 3.70 46.7 µM 3.78E-5 6 1.06E-4 0.07
8 SGTC_1365 1672-3266 3.69 55.4 µM 4.04E-5 8 1.12E-4 0.05
9 SGTC_2489 cantharidin 3.69 73.4 µM 4.04E-5 cell wall signaling 9 1.12E-4 0.01
10 SGTC_1221 2958-7315 3.67 257.0 µM 4.32E-5 2 1.19E-4 0.05
11 SGTC_800 3448-7362 3.56 155.0 µM 7.02E-5 translation 55 1.85E-4 0.09
12 SGTC_1219 1469-0211 3.46 33.1 µM 1.05E-4 7 2.66E-4 0.09
13 SGTC_1946 st076057 3.45 65.1 µM 1.10E-4 3 2.77E-4 0.40
14 SGTC_2186 6124449 3.43 200.0 µM 1.19E-4 RSC complex & mRNA processing 26 2.99E-4 0.01
15 SGTC_2811 7967822 3.43 32.5 µM 1.21E-4 9 3.03E-4 0.01
16 SGTC_114 0364-0001 3.38 490.3 µM 1.50E-4 14 3.68E-4 0.08
17 SGTC_2829 7992743 3.23 58.4 µM 2.63E-4 11 6.11E-4 0.00
18 SGTC_75 0159-0059 3.22 199.0 µM 2.72E-4 fatty acid desaturase (OLE1) 19 6.30E-4 0.10
19 SGTC_23 0213-0011 3.21 40.0 µM 2.84E-4 copper-dependent oxidative stress 9 6.54E-4 0.06
20 SGTC_2970 9090938 3.21 41.9 µM 2.93E-4 RNA processing & uracil transport 16 6.73E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.83E-20 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.122 1.28E-12 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.121 1.88E-12 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.113 5.49E-11 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.111 9.77E-11 YNL255C GIS2 hom Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
0.107 5.07E-10 YGL041C-B_p YGL041C-B_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.101 4.44E-9 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.099 7.76E-9 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.092 9.96E-8 YDR422C SIP1 hom Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
0.088 3.27E-7 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.088 3.64E-7 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.087 4.64E-7 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.081 2.33E-6 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.081 2.94E-6 YJL093C TOK1 hom Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
0.079 4.90E-6 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin