YJR005W / APL1

Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR005W / APL1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.73|P-value:1.32E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.60|P-value:3.51E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:3.28|P-value:6.72E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.65|P-value:1.81E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.45|P-value:7.16E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:4.03|P-value:4.08E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.25|P-value:7.32E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.30|P-value:6.12E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.24|P-value:9.69E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.21|P-value:8.36E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.27|P-value:6.85E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.26|P-value:7.06E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.57|P-value:2.41E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.22|P-value:8.14E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.33|P-value:5.55E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.26|P-value:1.58E-5 ID:SGTC_1808|Compound:st050063|FD-Score:-3.33|P-value:7.11E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.04|P-value:4.01E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.67|P-value:1.67E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.28|P-value:1.99E-5 ID:SGTC_1950|Compound:st077106|FD-Score:3.30|P-value:6.14E-4 ID:SGTC_1993|Compound:st073995|FD-Score:6.04|P-value:1.99E-9 ID:SGTC_1997|Compound:st073024|FD-Score:4.32|P-value:1.25E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.71|P-value:1.41E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.80|P-value:1.02E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.58|P-value:2.95E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.26|P-value:8.89E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-3.67|P-value:2.16E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.78|P-value:1.43E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.51|P-value:3.80E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.54|P-value:2.68E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.41|P-value:5.39E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.01|P-value:4.46E-5 ID:SGTC_2429|Compound:5902844|FD-Score:-3.78|P-value:1.46E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.76|P-value:1.20E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.17|P-value:9.57E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.58|P-value:3.02E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.87|P-value:7.92E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.00|P-value:4.63E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.37|P-value:6.12E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.52|P-value:2.93E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-4.02|P-value:5.61E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.60|P-value:2.15E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.19|P-value:8.92E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.39|P-value:4.63E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.31|P-value:7.60E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.45|P-value:4.75E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.73|P-value:1.32E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.60|P-value:3.51E-6 ID:SGTC_183|Compound:3914-0051|FD-Score:3.28|P-value:6.72E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.65|P-value:1.81E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.45|P-value:7.16E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:4.03|P-value:4.08E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.25|P-value:7.32E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.30|P-value:6.12E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.24|P-value:9.69E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.21|P-value:8.36E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.27|P-value:6.85E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.26|P-value:7.06E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.57|P-value:2.41E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.22|P-value:8.14E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.33|P-value:5.55E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.26|P-value:1.58E-5 ID:SGTC_1808|Compound:st050063|FD-Score:-3.33|P-value:7.11E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.04|P-value:4.01E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.67|P-value:1.67E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.28|P-value:1.99E-5 ID:SGTC_1950|Compound:st077106|FD-Score:3.30|P-value:6.14E-4 ID:SGTC_1993|Compound:st073995|FD-Score:6.04|P-value:1.99E-9 ID:SGTC_1997|Compound:st073024|FD-Score:4.32|P-value:1.25E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.71|P-value:1.41E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.80|P-value:1.02E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.58|P-value:2.95E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.26|P-value:8.89E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-3.67|P-value:2.16E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.78|P-value:1.43E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.51|P-value:3.80E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.54|P-value:2.68E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.41|P-value:5.39E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.01|P-value:4.46E-5 ID:SGTC_2429|Compound:5902844|FD-Score:-3.78|P-value:1.46E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.76|P-value:1.20E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.17|P-value:9.57E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.58|P-value:3.02E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.87|P-value:7.92E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.00|P-value:4.63E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.37|P-value:6.12E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.52|P-value:2.93E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-4.02|P-value:5.61E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.60|P-value:2.15E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.19|P-value:8.92E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.39|P-value:4.63E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.31|P-value:7.60E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.45|P-value:4.75E-4

Top fitness defect scores for YJR005W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1993 st073995 6.04 70.8 µM 1.99E-9 3 7.62E-10
2 SGTC_74 000s-0487 4.60 160.3 µM 3.51E-6 15 2.07E-6
3 SGTC_344 k064-0035 4.45 6.4 µM 7.16E-6 60S ribosome export 17 4.39E-6
4 SGTC_1997 st073024 4.32 93.8 µM 1.25E-5 6 7.91E-6
5 SGTC_1744 st037937 4.26 38.9 µM 1.58E-5 20 1.01E-5
6 SGTC_1820 st053765 4.04 18.6 µM 4.01E-5 RPP1 & pyrimidine depletion 15 2.71E-5
7 SGTC_661 1304-0007 4.03 33.6 µM 4.08E-5 20 2.75E-5
8 SGTC_2399 5884133 4.01 200.0 µM 4.46E-5 cell wall signaling 68 3.02E-5
9 SGTC_2794 7785382 4.00 27.3 µM 4.63E-5 35 3.15E-5
10 SGTC_2781 5567276 3.87 71.4 µM 7.92E-5 51 5.54E-5
11 SGTC_2056 5235370 3.80 200.0 µM 1.02E-4 47 7.25E-5
12 SGTC_72 0744-0168 3.78 198.4 µM 1.10E-4 RPP1 & pyrimidine depletion 33 7.81E-5
13 SGTC_2450 5739737 3.76 12.9 µM 1.20E-4 30 8.60E-5
14 SGTC_39 0986-0283 3.73 58.4 µM 1.32E-4 calcium & mitochondrial duress 46 9.48E-5
15 SGTC_2009 4012297 3.71 12.1 µM 1.41E-4 cell wall signaling 68 1.02E-4
16 SGTC_1844 rapamycin 3.67 4.0 nM 1.67E-4 184 1.21E-4
17 SGTC_269 exalamide 3.65 29.0 µM 1.81E-4 ergosterol biosynthesis 24 1.33E-4
18 SGTC_2875 9039966 3.60 71.4 µM 2.15E-4 16 1.59E-4
19 SGTC_1295 1013-0063 3.57 9.8 µM 2.41E-4 22 1.79E-4
20 SGTC_2285 7945142 3.54 200.0 µM 2.68E-4 32 2.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.68E-12 YLR100W ERG27 het 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
0.115 2.51E-11 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.098 1.14E-8 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.093 6.21E-8 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.092 8.76E-8 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.087 4.00E-7 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.086 5.32E-7 YKR049C FMP46 hom Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.086 6.38E-7 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.082 1.77E-6 YOR293C-A_p YOR293C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.082 2.02E-6 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.081 2.45E-6 YER186C_p YER186C_p hom Putative protein of unknown function
0.077 7.65E-6 YBL037W APL3 hom Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
0.077 8.35E-6 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.076 1.05E-5 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.076 1.07E-5 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene