YJR007W / SUI2

Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR007W / SUI2

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:6.18|P-value:1.89E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:6.42|P-value:7.70E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:7.13|P-value:4.72E-8 ID:SGTC_66|Compound:0109-0187|FD-Score:5.77|P-value:7.82E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:6.61|P-value:3.85E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:5.37|P-value:2.90E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.32|P-value:3.42E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:11.40|P-value:5.62E-18 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.81|P-value:1.58E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:5.38|P-value:2.87E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.38|P-value:5.29E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:6.73|P-value:2.37E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:4.21|P-value:8.14E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.19|P-value:5.11E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:6.29|P-value:1.24E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:5.20|P-value:4.99E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.61|P-value:2.76E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:6.03|P-value:3.24E-6 ID:SGTC_713|Compound:1488-1073|FD-Score:5.29|P-value:3.78E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.17|P-value:9.03E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.36|P-value:5.49E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.63|P-value:1.26E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.24|P-value:7.48E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:4.63|P-value:2.64E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:5.94|P-value:4.47E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.75|P-value:1.91E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.51|P-value:3.72E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:6.22|P-value:1.61E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.22|P-value:4.75E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.33|P-value:6.04E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-4.37|P-value:5.36E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.25|P-value:7.29E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-4.61|P-value:2.75E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-5.40|P-value:2.63E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.77|P-value:1.81E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.32|P-value:6.05E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.25|P-value:7.28E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.30|P-value:6.43E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.32|P-value:6.20E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.53|P-value:3.46E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.58|P-value:2.98E-4 ID:SGTC_1647|Compound:st011722|FD-Score:4.86|P-value:1.40E-4 ID:SGTC_1726|Compound:st035556|FD-Score:7.17|P-value:4.01E-8 ID:SGTC_1745|Compound:st081495|FD-Score:5.02|P-value:8.50E-5 ID:SGTC_1773|Compound:st048542|FD-Score:6.77|P-value:2.04E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-6.85|P-value:1.47E-7 ID:SGTC_1855|Compound:st056195|FD-Score:-4.55|P-value:3.27E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.62|P-value:2.75E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.98|P-value:9.86E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.33|P-value:3.32E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.54|P-value:3.45E-4 ID:SGTC_2057|Compound:5236571|FD-Score:12.30|P-value:1.73E-20 ID:SGTC_2151|Compound:5563267|FD-Score:4.16|P-value:9.27E-4 ID:SGTC_2156|Compound:5649887|FD-Score:12.10|P-value:8.06E-20 ID:SGTC_2179|Compound:6298986|FD-Score:-5.00|P-value:9.10E-5 ID:SGTC_2276|Compound:7947513|FD-Score:4.37|P-value:5.42E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-6.39|P-value:8.65E-7 ID:SGTC_2430|Compound:5571206|FD-Score:4.44|P-value:4.47E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-4.46|P-value:4.22E-4 ID:SGTC_2448|Compound:5185112|FD-Score:5.09|P-value:7.06E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.76|P-value:1.82E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.44|P-value:4.43E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.23|P-value:7.57E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.24|P-value:4.39E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.09|P-value:5.63E-8 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:8.67|P-value:4.42E-11 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-9.35|P-value:1.28E-12 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.21|P-value:4.78E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.39|P-value:4.97E-4 ID:SGTC_2825|Compound:7998094|FD-Score:5.31|P-value:3.56E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.88|P-value:1.29E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.75|P-value:1.92E-4 ID:SGTC_2887|Compound:9044784|FD-Score:6.27|P-value:1.37E-6 ID:SGTC_2893|Compound:9048488|FD-Score:5.64|P-value:1.21E-5 ID:SGTC_2911|Compound:7942208|FD-Score:4.47|P-value:4.16E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-6.59|P-value:4.00E-7 ID:SGTC_2991|Compound:9074669|FD-Score:-5.62|P-value:1.29E-5 ID:SGTC_2993|Compound:9054257|FD-Score:6.10|P-value:2.54E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.81|P-value:1.60E-4 ID:SGTC_3040|Compound:9091894|FD-Score:4.67|P-value:2.35E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.88|P-value:1.31E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-5.46|P-value:2.14E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.26|P-value:7.20E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.21|P-value:8.22E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-4.38|P-value:5.12E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-6.72|P-value:2.44E-7 ID:SGTC_3347|Compound:9188721|FD-Score:5.75|P-value:8.46E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:6.18|P-value:1.89E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:6.42|P-value:7.70E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:7.13|P-value:4.72E-8 ID:SGTC_66|Compound:0109-0187|FD-Score:5.77|P-value:7.82E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:6.61|P-value:3.85E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:5.37|P-value:2.90E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:5.32|P-value:3.42E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:11.40|P-value:5.62E-18 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.81|P-value:1.58E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:5.38|P-value:2.87E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.38|P-value:5.29E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:6.73|P-value:2.37E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:4.21|P-value:8.14E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.19|P-value:5.11E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:6.29|P-value:1.24E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:5.20|P-value:4.99E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.61|P-value:2.76E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:6.03|P-value:3.24E-6 ID:SGTC_713|Compound:1488-1073|FD-Score:5.29|P-value:3.78E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.17|P-value:9.03E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.36|P-value:5.49E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.63|P-value:1.26E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.24|P-value:7.48E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:4.63|P-value:2.64E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:5.94|P-value:4.47E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.75|P-value:1.91E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.51|P-value:3.72E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:6.22|P-value:1.61E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.22|P-value:4.75E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.33|P-value:6.04E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-4.37|P-value:5.36E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.25|P-value:7.29E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-4.61|P-value:2.75E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-5.40|P-value:2.63E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.77|P-value:1.81E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.32|P-value:6.05E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.25|P-value:7.28E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.30|P-value:6.43E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.32|P-value:6.20E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.53|P-value:3.46E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.58|P-value:2.98E-4 ID:SGTC_1647|Compound:st011722|FD-Score:4.86|P-value:1.40E-4 ID:SGTC_1726|Compound:st035556|FD-Score:7.17|P-value:4.01E-8 ID:SGTC_1745|Compound:st081495|FD-Score:5.02|P-value:8.50E-5 ID:SGTC_1773|Compound:st048542|FD-Score:6.77|P-value:2.04E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-6.85|P-value:1.47E-7 ID:SGTC_1855|Compound:st056195|FD-Score:-4.55|P-value:3.27E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.62|P-value:2.75E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.98|P-value:9.86E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.33|P-value:3.32E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.54|P-value:3.45E-4 ID:SGTC_2057|Compound:5236571|FD-Score:12.30|P-value:1.73E-20 ID:SGTC_2151|Compound:5563267|FD-Score:4.16|P-value:9.27E-4 ID:SGTC_2156|Compound:5649887|FD-Score:12.10|P-value:8.06E-20 ID:SGTC_2179|Compound:6298986|FD-Score:-5.00|P-value:9.10E-5 ID:SGTC_2276|Compound:7947513|FD-Score:4.37|P-value:5.42E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-6.39|P-value:8.65E-7 ID:SGTC_2430|Compound:5571206|FD-Score:4.44|P-value:4.47E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-4.46|P-value:4.22E-4 ID:SGTC_2448|Compound:5185112|FD-Score:5.09|P-value:7.06E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.76|P-value:1.82E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.44|P-value:4.43E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.23|P-value:7.57E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.24|P-value:4.39E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.09|P-value:5.63E-8 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:8.67|P-value:4.42E-11 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-9.35|P-value:1.28E-12 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.21|P-value:4.78E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.39|P-value:4.97E-4 ID:SGTC_2825|Compound:7998094|FD-Score:5.31|P-value:3.56E-5 ID:SGTC_2858|Compound:9025781|FD-Score:4.88|P-value:1.29E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.75|P-value:1.92E-4 ID:SGTC_2887|Compound:9044784|FD-Score:6.27|P-value:1.37E-6 ID:SGTC_2893|Compound:9048488|FD-Score:5.64|P-value:1.21E-5 ID:SGTC_2911|Compound:7942208|FD-Score:4.47|P-value:4.16E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-6.59|P-value:4.00E-7 ID:SGTC_2991|Compound:9074669|FD-Score:-5.62|P-value:1.29E-5 ID:SGTC_2993|Compound:9054257|FD-Score:6.10|P-value:2.54E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.81|P-value:1.60E-4 ID:SGTC_3040|Compound:9091894|FD-Score:4.67|P-value:2.35E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.88|P-value:1.31E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-5.46|P-value:2.14E-5 ID:SGTC_3200|Compound:9114385|FD-Score:4.26|P-value:7.20E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.21|P-value:8.22E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-4.38|P-value:5.12E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-6.72|P-value:2.44E-7 ID:SGTC_3347|Compound:9188721|FD-Score:5.75|P-value:8.46E-6

Top fitness defect scores for YJR007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2057 5236571 12.30 38.3 µM 1.73E-20 RPP1 & pyrimidine depletion 3 4.73E-35 0.97
2 SGTC_2156 5649887 12.10 115.0 µM 8.06E-20 RPP1 & pyrimidine depletion 4 7.29E-34 2.69
3 SGTC_163 1327-0036 11.40 7.5 µM 5.62E-18 11 1.36E-30 0.33
4 SGTC_2658 polymyxin b sulfate 8.67 77.0 µM 4.42E-11 NEO1 4 2.24E-18 1.07
5 SGTC_1726 st035556 7.17 14.6 µM 4.01E-8 1 3.71E-13 1.49
6 SGTC_59 0330-0160 7.13 1.3 µM 4.72E-8 1 4.94E-13 1.27
7 SGTC_2651 1327-0036 7.09 5.0 µM 5.63E-8 25 6.74E-13 0.23
8 SGTC_1773 st048542 6.77 73.6 µM 2.04E-7 8 6.51E-12 0.19
9 SGTC_274 sirtinol 6.73 40.1 µM 2.37E-7 4 8.45E-12 0.01
10 SGTC_87 0100-0052 6.61 35.5 µM 3.85E-7 5 1.99E-11 0.97
11 SGTC_53 0973-0023 6.42 40.0 µM 7.70E-7 RNA processing & uracil transport 2 6.71E-11 0.95
12 SGTC_371 0195-0006 6.29 7.4 µM 1.24E-6 3 1.55E-10 0.79
13 SGTC_2887 9044784 6.27 58.4 µM 1.37E-6 fatty acid desaturase (OLE1) 7 1.85E-10 0.63
14 SGTC_1124 fisetin 6.22 1.2 µM 1.61E-6 3 2.45E-10 0.47
15 SGTC_52 0329-0193 6.18 875.0 nM 1.89E-6 TSC3-RPN4 2 3.25E-10 0.91
16 SGTC_2993 9054257 6.10 71.4 µM 2.54E-6 fatty acid desaturase (OLE1) 13 5.45E-10 0.07
17 SGTC_708 3448-5400 6.03 146.0 µM 3.24E-6 2 8.35E-10 0.03
18 SGTC_1008 4106-0037 5.94 6.0 µM 4.47E-6 PDR1 1 1.47E-9 1.23
19 SGTC_66 0109-0187 5.77 42.4 µM 7.82E-6 3 3.90E-9 0.63
20 SGTC_3347 9188721 5.75 44.7 µM 8.46E-6 8 4.48E-9 1.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.336 2.20E-89 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.325 2.91E-83 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.228 7.87E-41 YER025W GCD11 het Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
0.221 1.88E-38 YDL150W RPC53 het RNA polymerase III subunit C53
0.209 1.75E-34 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.194 8.40E-30 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.189 2.12E-28 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.181 6.71E-26 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.180 7.90E-26 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.173 7.15E-24 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.169 6.45E-23 YOR146W_d YOR146W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
0.165 7.72E-22 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.165 7.76E-22 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.164 1.50E-21 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.161 6.37E-21 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria