YJR013W / GPI14

Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR013W / GPI14

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.52|P-value:2.42E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.30|P-value:5.40E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.77|P-value:7.02E-15 ID:SGTC_81|Compound:0411-0046|FD-Score:8.96|P-value:3.67E-19 ID:SGTC_108|Compound:0509-0257|FD-Score:4.01|P-value:3.59E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.13|P-value:1.86E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.43|P-value:3.92E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:3.60|P-value:1.83E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.79|P-value:8.72E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.24|P-value:6.63E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.46|P-value:4.96E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:41.10|P-value:0 ID:SGTC_168|Compound:3970-0862|FD-Score:8.22|P-value:2.02E-16 ID:SGTC_184|Compound:1494-0393|FD-Score:3.15|P-value:8.93E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.27|P-value:5.90E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:7.20|P-value:5.26E-13 ID:SGTC_266|Compound:formosanin C|FD-Score:12.20|P-value:6.12E-34 ID:SGTC_309|Compound:k408-0051|FD-Score:7.87|P-value:3.44E-15 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.16|P-value:8.79E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.97|P-value:4.39E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:5.50|P-value:2.52E-8 ID:SGTC_376|Compound:3970-0862|FD-Score:3.21|P-value:7.35E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.88|P-value:6.30E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:7.54|P-value:4.05E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:5.81|P-value:4.48E-9 ID:SGTC_540|Compound:1187-0821|FD-Score:3.91|P-value:5.48E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.49|P-value:2.76E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.42|P-value:6.11E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.35|P-value:4.53E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.60|P-value:1.46E-8 ID:SGTC_839|Compound:0122-0028|FD-Score:4.24|P-value:1.37E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.21|P-value:1.55E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.91|P-value:5.41E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.71|P-value:1.51E-11 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.38|P-value:4.16E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.16|P-value:8.87E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.28|P-value:1.11E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.22|P-value:7.23E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.65|P-value:2.02E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.15|P-value:8.94E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.46|P-value:3.21E-8 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.64|P-value:1.63E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.15|P-value:9.03E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:23.60|P-value:4.16E-121 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.60|P-value:1.80E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.74|P-value:1.05E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.49|P-value:2.70E-8 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.53|P-value:2.37E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.21|P-value:7.46E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.85|P-value:6.92E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:4.09|P-value:2.59E-5 ID:SGTC_1678|Compound:st019265|FD-Score:4.47|P-value:4.72E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.63|P-value:1.69E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.52|P-value:2.41E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.20|P-value:1.63E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.72|P-value:7.49E-9 ID:SGTC_1724|Compound:st037281|FD-Score:-4.17|P-value:1.90E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.79|P-value:8.60E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-5.20|P-value:1.37E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-9.18|P-value:5.32E-20 ID:SGTC_1750|Compound:st081859|FD-Score:4.78|P-value:1.12E-6 ID:SGTC_1765|Compound:st044815|FD-Score:4.57|P-value:2.99E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.49|P-value:2.75E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.51|P-value:2.53E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.32|P-value:5.16E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.29|P-value:5.75E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.20|P-value:1.32E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.96|P-value:4.50E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:5.34|P-value:6.06E-8 ID:SGTC_1892|Compound:st058411|FD-Score:4.73|P-value:1.38E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.38|P-value:4.07E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.50|P-value:4.08E-6 ID:SGTC_2040|Compound:5100729|FD-Score:18.40|P-value:4.78E-74 ID:SGTC_2139|Compound:5578692|FD-Score:3.91|P-value:5.46E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.61|P-value:1.77E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.75|P-value:1.06E-4 ID:SGTC_2374|Compound:9071832|FD-Score:4.66|P-value:1.95E-6 ID:SGTC_2377|Compound:9073351|FD-Score:-3.40|P-value:3.88E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.24|P-value:6.66E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.26|P-value:6.32E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:16.90|P-value:4.37E-63 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.62|P-value:2.36E-14 ID:SGTC_2584|Compound:androsterone|FD-Score:5.81|P-value:4.30E-9 ID:SGTC_2606|Compound:farnesol|FD-Score:5.74|P-value:6.63E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:8.77|P-value:1.89E-18 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.10|P-value:2.47E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:22.50|P-value:1.46E-110 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.09|P-value:2.54E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.78|P-value:1.77E-18 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.29|P-value:5.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.29|P-value:1.12E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-3.40|P-value:3.92E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.13|P-value:9.78E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.89|P-value:5.76E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.69|P-value:1.30E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.16|P-value:8.82E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.56|P-value:3.20E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:6.32|P-value:1.93E-10 ID:SGTC_3063|Compound:1327-0034|FD-Score:5.93|P-value:2.13E-9 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.40|P-value:3.74E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.33|P-value:4.90E-4 ID:SGTC_3243|Compound:9134147|FD-Score:4.91|P-value:5.92E-7 ID:SGTC_20|Compound:0481-0013|FD-Score:3.52|P-value:2.42E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.30|P-value:5.40E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.77|P-value:7.02E-15 ID:SGTC_81|Compound:0411-0046|FD-Score:8.96|P-value:3.67E-19 ID:SGTC_108|Compound:0509-0257|FD-Score:4.01|P-value:3.59E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.13|P-value:1.86E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.43|P-value:3.92E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:3.60|P-value:1.83E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.79|P-value:8.72E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.24|P-value:6.63E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.46|P-value:4.96E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:41.10|P-value:0 ID:SGTC_168|Compound:3970-0862|FD-Score:8.22|P-value:2.02E-16 ID:SGTC_184|Compound:1494-0393|FD-Score:3.15|P-value:8.93E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.27|P-value:5.90E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:7.20|P-value:5.26E-13 ID:SGTC_266|Compound:formosanin C|FD-Score:12.20|P-value:6.12E-34 ID:SGTC_309|Compound:k408-0051|FD-Score:7.87|P-value:3.44E-15 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.16|P-value:8.79E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.97|P-value:4.39E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:5.50|P-value:2.52E-8 ID:SGTC_376|Compound:3970-0862|FD-Score:3.21|P-value:7.35E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.88|P-value:6.30E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:7.54|P-value:4.05E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:5.81|P-value:4.48E-9 ID:SGTC_540|Compound:1187-0821|FD-Score:3.91|P-value:5.48E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.49|P-value:2.76E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.42|P-value:6.11E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.35|P-value:4.53E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.60|P-value:1.46E-8 ID:SGTC_839|Compound:0122-0028|FD-Score:4.24|P-value:1.37E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.21|P-value:1.55E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.91|P-value:5.41E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.71|P-value:1.51E-11 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.38|P-value:4.16E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.16|P-value:8.87E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.28|P-value:1.11E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.22|P-value:7.23E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.65|P-value:2.02E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.15|P-value:8.94E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.46|P-value:3.21E-8 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.64|P-value:1.63E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.15|P-value:9.03E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:23.60|P-value:4.16E-121 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.60|P-value:1.80E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.74|P-value:1.05E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.49|P-value:2.70E-8 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.53|P-value:2.37E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.21|P-value:7.46E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.85|P-value:6.92E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:4.09|P-value:2.59E-5 ID:SGTC_1678|Compound:st019265|FD-Score:4.47|P-value:4.72E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.63|P-value:1.69E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.52|P-value:2.41E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.20|P-value:1.63E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.72|P-value:7.49E-9 ID:SGTC_1724|Compound:st037281|FD-Score:-4.17|P-value:1.90E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.79|P-value:8.60E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-5.20|P-value:1.37E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-9.18|P-value:5.32E-20 ID:SGTC_1750|Compound:st081859|FD-Score:4.78|P-value:1.12E-6 ID:SGTC_1765|Compound:st044815|FD-Score:4.57|P-value:2.99E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.49|P-value:2.75E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.51|P-value:2.53E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.32|P-value:5.16E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.29|P-value:5.75E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.20|P-value:1.32E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.96|P-value:4.50E-7 ID:SGTC_1880|Compound:MG-132|FD-Score:5.34|P-value:6.06E-8 ID:SGTC_1892|Compound:st058411|FD-Score:4.73|P-value:1.38E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.38|P-value:4.07E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.50|P-value:4.08E-6 ID:SGTC_2040|Compound:5100729|FD-Score:18.40|P-value:4.78E-74 ID:SGTC_2139|Compound:5578692|FD-Score:3.91|P-value:5.46E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.61|P-value:1.77E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.75|P-value:1.06E-4 ID:SGTC_2374|Compound:9071832|FD-Score:4.66|P-value:1.95E-6 ID:SGTC_2377|Compound:9073351|FD-Score:-3.40|P-value:3.88E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.24|P-value:6.66E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.26|P-value:6.32E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:16.90|P-value:4.37E-63 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.62|P-value:2.36E-14 ID:SGTC_2584|Compound:androsterone|FD-Score:5.81|P-value:4.30E-9 ID:SGTC_2606|Compound:farnesol|FD-Score:5.74|P-value:6.63E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:8.77|P-value:1.89E-18 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.10|P-value:2.47E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:22.50|P-value:1.46E-110 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.09|P-value:2.54E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.78|P-value:1.77E-18 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.29|P-value:5.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.29|P-value:1.12E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-3.40|P-value:3.92E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.13|P-value:9.78E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.89|P-value:5.76E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.69|P-value:1.30E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.16|P-value:8.82E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.56|P-value:3.20E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:6.32|P-value:1.93E-10 ID:SGTC_3063|Compound:1327-0034|FD-Score:5.93|P-value:2.13E-9 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.40|P-value:3.74E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.33|P-value:4.90E-4 ID:SGTC_3243|Compound:9134147|FD-Score:4.91|P-value:5.92E-7

Top fitness defect scores for YJR013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 41.10 7.5 µM 0 1 0 18.80
2 SGTC_1309 pyrazolanthrone 23.60 13.4 µM 4.16E-121 1 1.34E-123 16.00
3 SGTC_2651 1327-0036 22.50 5.0 µM 1.46E-110 3 7.86E-113 3.53
4 SGTC_2040 5100729 18.40 123.0 µM 4.78E-74 1 1.51E-75 7.65
5 SGTC_2567 aureobasidin a 16.90 60.0 nM 4.37E-63 6 2.34E-64 0.32
6 SGTC_266 formosanin C 12.20 406.0 nM 6.12E-34 sphingolipid biosynthesis & PDR1 2 1.33E-34 0.88
7 SGTC_81 0411-0046 8.96 10.0 µM 3.67E-19 10 1.62E-19 0.50
8 SGTC_2679 rapamycin 8.78 1.0 nM 1.77E-18 14 8.07E-19 0.82
9 SGTC_2612 dictamnine 8.77 15.5 µM 1.89E-18 RNA pol III & RNase P/MRP 9 8.66E-19 0.09
10 SGTC_168 3970-0862 8.22 530.5 µM 2.02E-16 8 1.02E-16 0.38
11 SGTC_309 k408-0051 7.87 1.5 µM 3.44E-15 4 1.84E-15 0.79
12 SGTC_58 0957-0393 7.77 9.0 µM 7.02E-15 cell wall 19 3.80E-15 0.03
13 SGTC_2582 agaric acid 7.62 100.0 µM 2.36E-14 redox potentiating 11 1.31E-14 0.06
14 SGTC_435 c-PAF 7.54 6.7 µM 4.05E-14 5 2.27E-14 1.37
15 SGTC_214 4373-3496 7.20 70.0 µM 5.26E-13 4 3.11E-13 1.36
16 SGTC_996 3970-0799 6.71 1.8 µM 1.51E-11 7 9.55E-12 0.84
17 SGTC_3060 1327-0027 6.32 12.5 µM 1.93E-10 4 1.29E-10 2.23
18 SGTC_3063 1327-0034 5.93 4.0 µM 2.13E-9 3 1.49E-9 0.09
19 SGTC_2584 androsterone 5.81 48.7 µM 4.30E-9 cell wall 14 3.05E-9 0.29
20 SGTC_513 4245-1575 5.81 41.7 µM 4.48E-9 unfolded protein response 11 3.18E-9 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.558 1.87E-274 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.475 1.23E-188 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.456 5.28E-172 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.426 4.38E-148 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.410 4.28E-136 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.397 8.94E-127 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.389 9.94E-122 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.388 5.40E-121 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.385 6.75E-119 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.378 3.01E-114 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.371 3.15E-110 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.370 4.07E-109 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.361 1.24E-103 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.339 4.42E-91 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.315 2.62E-78 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol