YJR014W / TMA22

Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR014W / TMA22

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.55|P-value:1.67E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.71|P-value:8.03E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.05|P-value:1.12E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.41|P-value:5.53E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:4.34|P-value:9.22E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:4.04|P-value:5.68E-7 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.58|P-value:1.43E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.72|P-value:3.65E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.46|P-value:8.36E-8 ID:SGTC_548|Compound:1436-0017|FD-Score:2.81|P-value:3.34E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:2.92|P-value:2.06E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.04|P-value:1.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:2.99|P-value:1.46E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.82|P-value:3.14E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-2.76|P-value:6.62E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.76|P-value:4.17E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:8.32|P-value:1.26E-23 ID:SGTC_1108|Compound:betulinic acid|FD-Score:2.75|P-value:4.37E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.08|P-value:9.60E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-2.74|P-value:7.29E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.69|P-value:5.48E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-2.70|P-value:8.45E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-2.90|P-value:3.76E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:2.98|P-value:1.56E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.66|P-value:6.19E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.46|P-value:1.53E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.57|P-value:9.18E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.05|P-value:1.89E-4 ID:SGTC_1685|Compound:st024049|FD-Score:2.56|P-value:9.52E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.46|P-value:1.49E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-2.94|P-value:3.04E-4 ID:SGTC_1893|Compound:st059353|FD-Score:2.83|P-value:3.11E-4 ID:SGTC_1898|Compound:st060199|FD-Score:2.75|P-value:4.36E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.01|P-value:2.24E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.08|P-value:9.78E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.99|P-value:7.65E-7 ID:SGTC_2049|Compound:5262831|FD-Score:3.26|P-value:4.14E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-2.85|P-value:4.65E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-2.69|P-value:8.78E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.23|P-value:4.83E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.18|P-value:1.03E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.03|P-value:1.17E-6 ID:SGTC_2352|Compound:9027995|FD-Score:-2.75|P-value:6.89E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:2.76|P-value:4.06E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.86|P-value:4.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.87|P-value:1.53E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-4.31|P-value:2.25E-7 ID:SGTC_2835|Compound:9006588|FD-Score:-3.53|P-value:1.83E-5 ID:SGTC_2848|Compound:9016370|FD-Score:2.84|P-value:2.89E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.52|P-value:1.07E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.24|P-value:8.00E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.55|P-value:1.67E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.71|P-value:8.03E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.05|P-value:1.12E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.41|P-value:5.53E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:4.34|P-value:9.22E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:4.04|P-value:5.68E-7 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.58|P-value:1.43E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.72|P-value:3.65E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.46|P-value:8.36E-8 ID:SGTC_548|Compound:1436-0017|FD-Score:2.81|P-value:3.34E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:2.92|P-value:2.06E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.04|P-value:1.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:2.99|P-value:1.46E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.82|P-value:3.14E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-2.76|P-value:6.62E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.76|P-value:4.17E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:8.32|P-value:1.26E-23 ID:SGTC_1108|Compound:betulinic acid|FD-Score:2.75|P-value:4.37E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.08|P-value:9.60E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-2.74|P-value:7.29E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.69|P-value:5.48E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-2.70|P-value:8.45E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-2.90|P-value:3.76E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:2.98|P-value:1.56E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.66|P-value:6.19E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.46|P-value:1.53E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.57|P-value:9.18E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.05|P-value:1.89E-4 ID:SGTC_1685|Compound:st024049|FD-Score:2.56|P-value:9.52E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.46|P-value:1.49E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-2.94|P-value:3.04E-4 ID:SGTC_1893|Compound:st059353|FD-Score:2.83|P-value:3.11E-4 ID:SGTC_1898|Compound:st060199|FD-Score:2.75|P-value:4.36E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.01|P-value:2.24E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.08|P-value:9.78E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.99|P-value:7.65E-7 ID:SGTC_2049|Compound:5262831|FD-Score:3.26|P-value:4.14E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-2.85|P-value:4.65E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-2.69|P-value:8.78E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.23|P-value:4.83E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.18|P-value:1.03E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-4.03|P-value:1.17E-6 ID:SGTC_2352|Compound:9027995|FD-Score:-2.75|P-value:6.89E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:2.76|P-value:4.06E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.86|P-value:4.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.87|P-value:1.53E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-4.31|P-value:2.25E-7 ID:SGTC_2835|Compound:9006588|FD-Score:-3.53|P-value:1.83E-5 ID:SGTC_2848|Compound:9016370|FD-Score:2.84|P-value:2.89E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.52|P-value:1.07E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.24|P-value:8.00E-5

Top fitness defect scores for YJR014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 8.32 1.8 µM 1.26E-23 18 4.24E-17
2 SGTC_379 3970-0972 4.41 5.9 µM 5.53E-8 tubulin folding & SWR complex 26 5.07E-6
3 SGTC_384 k007-0144 4.34 5.2 µM 9.22E-8 ERAD & cell cycle 49 7.28E-6
4 SGTC_386 1509-0011 4.04 3.1 µM 5.68E-7 141 2.65E-5
5 SGTC_1978 st071761 3.99 42.0 µM 7.65E-7 TSC3-RPN4 15 3.27E-5
6 SGTC_2688 kanamycin b 3.87 96.7 µM 1.53E-6 calcium & mitochondrial duress 383 5.36E-5
7 SGTC_435 c-PAF 3.72 6.7 µM 3.65E-6 54 9.95E-5
8 SGTC_2974 9094440 3.52 9.7 µM 1.07E-5 ergosterol biosynthesis 56 2.13E-4
9 SGTC_1726 st035556 3.46 14.6 µM 1.49E-5 59 2.70E-4
10 SGTC_1409 3909-8004 3.46 61.9 µM 1.53E-5 38 2.75E-4
11 SGTC_2049 5262831 3.26 67.2 µM 4.14E-5 62 5.60E-4
12 SGTC_2261 9010538 3.23 184.7 µM 4.83E-5 35 6.26E-4
13 SGTC_1161 k007-0610 3.08 110.0 µM 9.60E-5 ERAD & cell cycle 166 0.00102
14 SGTC_1903 st060211 3.08 78.3 µM 9.78E-5 70 0.00103
15 SGTC_260 nsc-65238 3.05 4.0 µM 1.12E-4 endomembrane recycling 42 0.00114
16 SGTC_762 1165-0429 3.04 115.0 µM 1.19E-4 TSC3-RPN4 59 0.00119
17 SGTC_830 4076-0286 2.99 57.8 µM 1.46E-4 translation 149 0.00138
18 SGTC_1366 1683-0113 2.98 21.9 µM 1.56E-4 38 0.00144
19 SGTC_648 0375-0473 2.92 33.3 µM 2.06E-4 64 0.00176
20 SGTC_2848 9016370 2.84 26.0 µM 2.89E-4 83 0.00224

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.401 1.35E-129 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.319 3.79E-80 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.283 9.22E-63 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.260 5.96E-53 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.254 1.45E-50 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.248 4.54E-48 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.245 5.29E-47 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.225 1.31E-39 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.223 8.11E-39 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.217 3.64E-37 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.214 6.12E-36 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.205 3.22E-33 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.198 6.45E-31 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.195 3.94E-30 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.191 6.03E-29 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth