YJR017C / ESS1

Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR017C / ESS1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:4.98|P-value:4.56E-8 ID:SGTC_65|Compound:0798-0905|FD-Score:4.83|P-value:1.09E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.85|P-value:1.71E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.57|P-value:6.18E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.25|P-value:2.48E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.18|P-value:1.35E-8 ID:SGTC_355|Compound:1311-2252|FD-Score:-4.18|P-value:3.48E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:5.18|P-value:1.39E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:7.27|P-value:3.08E-15 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.52|P-value:5.84E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.37|P-value:3.60E-12 ID:SGTC_540|Compound:1187-0821|FD-Score:5.46|P-value:2.40E-9 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.72|P-value:3.07E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.17|P-value:3.48E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:2.94|P-value:8.32E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.02|P-value:5.84E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.13|P-value:3.78E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-2.98|P-value:6.74E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.10|P-value:4.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.12|P-value:3.83E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.07|P-value:4.69E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-4.10|P-value:5.21E-6 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.87|P-value:1.65E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.60|P-value:5.74E-5 ID:SGTC_1522|Compound:st012842|FD-Score:4.26|P-value:2.43E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.22|P-value:2.63E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.35|P-value:4.75E-12 ID:SGTC_1672|Compound:st016598|FD-Score:4.84|P-value:1.05E-7 ID:SGTC_1673|Compound:st016611|FD-Score:-3.12|P-value:3.95E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.04|P-value:5.67E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.32|P-value:1.89E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.91|P-value:8.98E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.17|P-value:3.27E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.17|P-value:3.36E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-2.88|P-value:9.58E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.57|P-value:6.49E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-4.75|P-value:1.65E-7 ID:SGTC_2994|Compound:9053520|FD-Score:3.32|P-value:1.85E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-2.89|P-value:9.23E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.98|P-value:4.56E-8 ID:SGTC_65|Compound:0798-0905|FD-Score:4.83|P-value:1.09E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.85|P-value:1.71E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.57|P-value:6.18E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.25|P-value:2.48E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.18|P-value:1.35E-8 ID:SGTC_355|Compound:1311-2252|FD-Score:-4.18|P-value:3.48E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:5.18|P-value:1.39E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:7.27|P-value:3.08E-15 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.52|P-value:5.84E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.37|P-value:3.60E-12 ID:SGTC_540|Compound:1187-0821|FD-Score:5.46|P-value:2.40E-9 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.72|P-value:3.07E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.17|P-value:3.48E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:2.94|P-value:8.32E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.02|P-value:5.84E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.13|P-value:3.78E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-2.98|P-value:6.74E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.10|P-value:4.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.12|P-value:3.83E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.07|P-value:4.69E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-4.10|P-value:5.21E-6 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.87|P-value:1.65E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.60|P-value:5.74E-5 ID:SGTC_1522|Compound:st012842|FD-Score:4.26|P-value:2.43E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.22|P-value:2.63E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.35|P-value:4.75E-12 ID:SGTC_1672|Compound:st016598|FD-Score:4.84|P-value:1.05E-7 ID:SGTC_1673|Compound:st016611|FD-Score:-3.12|P-value:3.95E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.04|P-value:5.67E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.32|P-value:1.89E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.91|P-value:8.98E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.17|P-value:3.27E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.17|P-value:3.36E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-2.88|P-value:9.58E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.57|P-value:6.49E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-4.75|P-value:1.65E-7 ID:SGTC_2994|Compound:9053520|FD-Score:3.32|P-value:1.85E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-2.89|P-value:9.23E-4

Top fitness defect scores for YJR017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_359 0081-0058 7.27 15.9 µM 3.08E-15 60S ribosome export 2 1.79E-13 0.97
2 SGTC_1626 st003712 6.35 1.8 µM 4.75E-12 1 1.06E-10 1.46
3 SGTC_540 1187-0821 5.46 17.3 µM 2.40E-9 1 2.41E-8 0.36
4 SGTC_341 1486-1430 5.18 230.0 µM 1.35E-8 12 1.08E-7 0.00
5 SGTC_356 1634-0012 5.18 32.5 µM 1.39E-8 3 1.11E-7 0.24
6 SGTC_41 0478-0632 4.98 82.6 µM 4.56E-8 9 3.13E-7 0.09
7 SGTC_1672 st016598 4.84 6.5 µM 1.05E-7 endomembrane recycling 13 6.48E-7 0.16
8 SGTC_65 0798-0905 4.83 35.0 µM 1.09E-7 calcium & mitochondrial duress 3 6.69E-7 0.06
9 SGTC_1522 st012842 4.26 45.6 µM 2.43E-6 RNA pol III & RNase P/MRP 11 1.01E-5 0.06
10 SGTC_1497 4476-2978 3.87 41.3 µM 1.65E-5 4 5.36E-5 0.14
11 SGTC_1521 st012942 3.60 49.4 µM 5.74E-5 5 1.60E-4 0.21
12 SGTC_2921 7974240 3.57 10.7 µM 6.49E-5 20 1.78E-4 0.01
13 SGTC_2994 9053520 3.32 71.4 µM 1.85E-4 RPP1 & pyrimidine depletion 15 4.44E-4 0.11
14 SGTC_1781 st038725 3.32 66.3 µM 1.89E-4 NEO1 16 4.53E-4 0.07
15 SGTC_265 mycophenolic acid 3.25 32.9 µM 2.48E-4 RPP1 & pyrimidine depletion 9 5.76E-4 0.10
16 SGTC_2807 7945238 3.17 52.0 µM 3.36E-4 7 7.51E-4 0.02
17 SGTC_604 1000-0114 3.17 314.0 µM 3.48E-4 7 7.74E-4 0.21
18 SGTC_1199 1638-0010 3.10 4.5 µM 4.55E-4 endomembrane recycling 14 9.81E-4 0.24
19 SGTC_1715 st032160 3.04 10.2 µM 5.67E-4 18 0.00119 0.02
20 SGTC_606 k015-0008 2.94 38.6 µM 8.32E-4 12 0.00167 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 2.94E-21 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.148 5.46E-18 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.143 9.44E-17 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.133 8.53E-15 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8
0.133 1.19E-14 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.124 5.25E-13 YJL082W IML2 hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
0.123 9.92E-13 YML120C NDI1 hom NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID
0.119 4.43E-12 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.113 4.85E-11 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.111 9.59E-11 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.111 1.17E-10 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.111 1.19E-10 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.109 2.39E-10 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.109 2.53E-10 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.107 6.18E-10 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome