YJR018W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR018W / YJR018W

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.55|P-value:4.01E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-11.10|P-value:6.70E-25 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.83|P-value:2.34E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:7.32|P-value:3.93E-12 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.86|P-value:2.20E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.44|P-value:8.82E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.92|P-value:1.14E-20 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.83|P-value:2.36E-8 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.07|P-value:6.36E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:3.81|P-value:1.67E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.62|P-value:1.23E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:5.27|P-value:3.84E-7 ID:SGTC_338|Compound:4055-0136|FD-Score:4.01|P-value:8.07E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:3.72|P-value:2.29E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.13|P-value:7.47E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.80|P-value:2.71E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.53|P-value:6.56E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.82|P-value:2.51E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.99|P-value:8.69E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.64|P-value:3.02E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:6.35|P-value:1.43E-9 ID:SGTC_616|Compound:4092-0450|FD-Score:3.46|P-value:5.42E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.03|P-value:1.18E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.46|P-value:5.44E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.01|P-value:7.94E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:4.46|P-value:1.40E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.95|P-value:9.85E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.40|P-value:6.69E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.19|P-value:4.03E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.72|P-value:2.30E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.17|P-value:1.59E-17 ID:SGTC_768|Compound:0384-0033|FD-Score:4.69|P-value:5.31E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.57|P-value:3.83E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.63|P-value:1.18E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.49|P-value:4.96E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.28|P-value:9.73E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.08|P-value:6.08E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.70|P-value:2.46E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.36|P-value:7.58E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.23|P-value:3.51E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.04|P-value:1.13E-6 ID:SGTC_1591|Compound:genipin|FD-Score:3.57|P-value:3.84E-4 ID:SGTC_1624|Compound:st003710|FD-Score:4.08|P-value:6.18E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.42|P-value:6.14E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.78|P-value:1.83E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.36|P-value:7.55E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.41|P-value:6.43E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.65|P-value:2.85E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-6.65|P-value:5.20E-10 ID:SGTC_2264|Compound:7948757|FD-Score:-4.47|P-value:2.26E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-6.41|P-value:2.10E-9 ID:SGTC_2289|Compound:7946404|FD-Score:7.20|P-value:8.40E-12 ID:SGTC_2348|Compound:9022543|FD-Score:4.66|P-value:5.97E-6 ID:SGTC_2399|Compound:5884133|FD-Score:4.54|P-value:9.92E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.89|P-value:1.22E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.26|P-value:3.99E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.57|P-value:8.95E-8 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.50|P-value:4.80E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.55|P-value:9.55E-6 ID:SGTC_2883|Compound:9059145|FD-Score:-3.98|P-value:1.40E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.88|P-value:1.31E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.85|P-value:1.45E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.09|P-value:1.66E-11 ID:SGTC_2921|Compound:7974240|FD-Score:3.79|P-value:1.79E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.51|P-value:4.67E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.46|P-value:8.19E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.39|P-value:6.84E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.46|P-value:8.26E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.44|P-value:8.68E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.63|P-value:3.10E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.77|P-value:3.01E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-4.68|P-value:9.46E-6 ID:SGTC_3222|Compound:9128301|FD-Score:-3.68|P-value:3.98E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.34|P-value:7.95E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-4.80|P-value:5.78E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:3.55|P-value:4.01E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-11.10|P-value:6.70E-25 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.83|P-value:2.34E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:7.32|P-value:3.93E-12 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.86|P-value:2.20E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.44|P-value:8.82E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.92|P-value:1.14E-20 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.83|P-value:2.36E-8 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.07|P-value:6.36E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:3.81|P-value:1.67E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-4.62|P-value:1.23E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:5.27|P-value:3.84E-7 ID:SGTC_338|Compound:4055-0136|FD-Score:4.01|P-value:8.07E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:3.72|P-value:2.29E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:5.13|P-value:7.47E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.80|P-value:2.71E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.53|P-value:6.56E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.82|P-value:2.51E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.99|P-value:8.69E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.64|P-value:3.02E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:6.35|P-value:1.43E-9 ID:SGTC_616|Compound:4092-0450|FD-Score:3.46|P-value:5.42E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.03|P-value:1.18E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.46|P-value:5.44E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.01|P-value:7.94E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:4.46|P-value:1.40E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.95|P-value:9.85E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.40|P-value:6.69E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.19|P-value:4.03E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.72|P-value:2.30E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.17|P-value:1.59E-17 ID:SGTC_768|Compound:0384-0033|FD-Score:4.69|P-value:5.31E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.57|P-value:3.83E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.63|P-value:1.18E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.49|P-value:4.96E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.28|P-value:9.73E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.08|P-value:6.08E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.70|P-value:2.46E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.36|P-value:7.58E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.23|P-value:3.51E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.04|P-value:1.13E-6 ID:SGTC_1591|Compound:genipin|FD-Score:3.57|P-value:3.84E-4 ID:SGTC_1624|Compound:st003710|FD-Score:4.08|P-value:6.18E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.42|P-value:6.14E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.78|P-value:1.83E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.36|P-value:7.55E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.41|P-value:6.43E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.65|P-value:2.85E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-6.65|P-value:5.20E-10 ID:SGTC_2264|Compound:7948757|FD-Score:-4.47|P-value:2.26E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-6.41|P-value:2.10E-9 ID:SGTC_2289|Compound:7946404|FD-Score:7.20|P-value:8.40E-12 ID:SGTC_2348|Compound:9022543|FD-Score:4.66|P-value:5.97E-6 ID:SGTC_2399|Compound:5884133|FD-Score:4.54|P-value:9.92E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.89|P-value:1.22E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.26|P-value:3.99E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.57|P-value:8.95E-8 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.50|P-value:4.80E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.55|P-value:9.55E-6 ID:SGTC_2883|Compound:9059145|FD-Score:-3.98|P-value:1.40E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.88|P-value:1.31E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.85|P-value:1.45E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.09|P-value:1.66E-11 ID:SGTC_2921|Compound:7974240|FD-Score:3.79|P-value:1.79E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.51|P-value:4.67E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.46|P-value:8.19E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.39|P-value:6.84E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.46|P-value:8.26E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.44|P-value:8.68E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.63|P-value:3.10E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.77|P-value:3.01E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-4.68|P-value:9.46E-6 ID:SGTC_3222|Compound:9128301|FD-Score:-3.68|P-value:3.98E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.34|P-value:7.95E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-4.80|P-value:5.78E-6

Top fitness defect scores for YJR018W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 9.92 40.9 µM 1.14E-20 cell wall 45 1.77E-23
2 SGTC_58 0957-0393 7.32 9.0 µM 3.93E-12 cell wall 154 1.26E-13
3 SGTC_2289 7946404 7.20 165.1 µM 8.40E-12 25 3.01E-13
4 SGTC_2912 7964298 7.09 10.9 µM 1.66E-11 cell wall 33 6.58E-13
5 SGTC_594 1487-1584 6.35 10.8 µM 1.43E-9 6 1.11E-10
6 SGTC_46 0329-0187a 5.83 2.2 µM 2.34E-8 30 2.75E-9
7 SGTC_241 5hr heat shock (37°C) + cantharidin 5.83 155.4 µM 2.36E-8 cell wall signaling 34 2.77E-9
8 SGTC_2582 agaric acid 5.57 100.0 µM 8.95E-8 redox potentiating 183 1.28E-8
9 SGTC_332 4112-0506 5.27 40.9 µM 3.84E-7 9 6.80E-8
10 SGTC_2489 cantharidin 5.26 73.4 µM 3.99E-7 cell wall signaling 16 7.11E-8
11 SGTC_422 cantharidin 5.13 155.0 µM 7.47E-7 cell wall signaling 30 1.46E-7
12 SGTC_1506 4226-2149 5.04 212.0 µM 1.13E-6 14 2.34E-7
13 SGTC_637 1181-0519 5.03 7.3 µM 1.18E-6 fatty acid desaturase (OLE1) 67 2.46E-7
14 SGTC_768 0384-0033 4.69 77.3 µM 5.31E-6 fatty acid desaturase (OLE1) 60 1.38E-6
15 SGTC_2348 9022543 4.66 33.4 µM 5.97E-6 mitochondrial processes 17 1.57E-6
16 SGTC_2688 kanamycin b 4.55 96.7 µM 9.55E-6 calcium & mitochondrial duress 292 2.69E-6
17 SGTC_2399 5884133 4.54 200.0 µM 9.92E-6 cell wall signaling 51 2.81E-6
18 SGTC_663 1486-0733 4.46 13.9 µM 1.40E-5 cell wall signaling 40 4.16E-6
19 SGTC_1386 3228-0095 4.23 33.8 µM 3.51E-5 15 1.19E-5
20 SGTC_710 3448-4187 4.19 58.0 µM 4.03E-5 fatty acid desaturase (OLE1) 51 1.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 2.78E-49 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.239 9.05E-45 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.236 1.05E-43 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.234 5.97E-43 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.230 1.37E-41 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.218 2.32E-37 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.215 2.14E-36 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.215 2.58E-36 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.208 3.35E-34 YNL271C BNI1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
0.206 2.22E-33 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.204 1.24E-32 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.203 1.32E-32 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.199 2.74E-31 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.188 3.97E-28 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.186 1.28E-27 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member