YJR019C / TES1

Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR019C / TES1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.15|P-value:1.01E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.07|P-value:7.56E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.05|P-value:8.64E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.41|P-value:2.34E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.49|P-value:1.72E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.20|P-value:4.82E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-4.75|P-value:4.84E-7 ID:SGTC_394|Compound:menadione|FD-Score:3.20|P-value:5.15E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.29|P-value:3.65E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.79|P-value:4.69E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.26|P-value:3.91E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.14|P-value:5.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.76|P-value:5.21E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.66|P-value:7.97E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.28|P-value:3.78E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.89|P-value:3.00E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.17|P-value:5.67E-4 ID:SGTC_1731|Compound:st035964|FD-Score:5.95|P-value:4.72E-10 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.12|P-value:6.38E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.03|P-value:9.47E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.21|P-value:7.54E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.81|P-value:3.84E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.90|P-value:3.05E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:6.02|P-value:3.02E-10 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.99|P-value:2.11E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.91|P-value:2.79E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.17|P-value:5.76E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.98|P-value:2.17E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-4.78|P-value:4.10E-7 ID:SGTC_2857|Compound:9024691|FD-Score:3.70|P-value:7.42E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-5.50|P-value:7.46E-9 ID:SGTC_2986|Compound:9022445|FD-Score:3.08|P-value:7.94E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.63|P-value:9.74E-7 ID:SGTC_3283|Compound:9109332|FD-Score:-3.74|P-value:5.86E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.02|P-value:9.64E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.15|P-value:1.01E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.07|P-value:7.56E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.05|P-value:8.64E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.41|P-value:2.34E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.49|P-value:1.72E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.20|P-value:4.82E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-4.75|P-value:4.84E-7 ID:SGTC_394|Compound:menadione|FD-Score:3.20|P-value:5.15E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.29|P-value:3.65E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.79|P-value:4.69E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.26|P-value:3.91E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.14|P-value:5.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.76|P-value:5.21E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.66|P-value:7.97E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.28|P-value:3.78E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.89|P-value:3.00E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.17|P-value:5.67E-4 ID:SGTC_1731|Compound:st035964|FD-Score:5.95|P-value:4.72E-10 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.12|P-value:6.38E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.03|P-value:9.47E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.21|P-value:7.54E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.81|P-value:3.84E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.90|P-value:3.05E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:6.02|P-value:3.02E-10 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.99|P-value:2.11E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.91|P-value:2.79E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.17|P-value:5.76E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.98|P-value:2.17E-5 ID:SGTC_2852|Compound:9023854|FD-Score:-4.78|P-value:4.10E-7 ID:SGTC_2857|Compound:9024691|FD-Score:3.70|P-value:7.42E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-5.50|P-value:7.46E-9 ID:SGTC_2986|Compound:9022445|FD-Score:3.08|P-value:7.94E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.63|P-value:9.74E-7 ID:SGTC_3283|Compound:9109332|FD-Score:-3.74|P-value:5.86E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.02|P-value:9.64E-4

Top fitness defect scores for YJR019C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2529 gangaleoidin 6.02 93.6 µM 3.02E-10 3 8.54E-10
2 SGTC_1731 st035964 5.95 63.0 µM 4.72E-10 6 1.30E-9
3 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.81 63.6 µM 3.84E-7 23 7.45E-7
4 SGTC_3137 9097352 4.63 49.5 µM 9.74E-7 20 1.80E-6
5 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.21 3.7 µM 7.54E-6 68 1.25E-5
6 SGTC_6 0844-0013 4.15 19.8 µM 1.01E-5 74 1.65E-5
7 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.99 92.6 µM 2.11E-5 27 3.32E-5
8 SGTC_2761 levamisole 3.98 97.9 µM 2.17E-5 15 3.42E-5
9 SGTC_2528 xanthyletin 3.90 44.8 µM 3.05E-5 24 4.73E-5
10 SGTC_2857 9024691 3.70 58.4 µM 7.42E-5 30 1.10E-4
11 SGTC_686 1319-0111 3.58 510.0 µM 1.19E-4 60S ribosome export 38 1.71E-4
12 SGTC_2371 9071574 3.53 200.0 µM 1.46E-4 20 2.09E-4
13 SGTC_2242 6630449 3.52 61.3 µM 1.53E-4 Golgi 56 2.18E-4
14 SGTC_367 0335-0881 3.49 7.1 µM 1.72E-4 ubiquinone biosynthesis & proteasome 101 2.44E-4
15 SGTC_366 0181-0206 3.41 4.3 µM 2.34E-4 Golgi 67 3.27E-4
16 SGTC_435 c-PAF 3.29 6.7 µM 3.65E-4 76 4.99E-4
17 SGTC_1214 0358-0031 3.28 63.7 µM 3.78E-4 36 5.15E-4
18 SGTC_394 menadione 3.20 8.3 µM 5.15E-4 superoxide 59 6.91E-4
19 SGTC_1725 st036284 3.17 20.6 µM 5.67E-4 65 7.57E-4
20 SGTC_2622 2-methoxyxanthone 3.17 59.9 µM 5.76E-4 39 7.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 1.96E-44 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.230 1.45E-41 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.204 9.85E-33 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.181 6.02E-26 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.180 6.81E-26 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.176 1.44E-24 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.171 2.14E-23 YDR099W BMH2 hom 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.167 3.02E-22 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.164 1.42E-21 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.145 2.75E-17 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.145 3.25E-17 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.145 3.87E-17 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.145 4.11E-17 YDR085C AFR1 hom Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication
0.142 1.94E-16 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.140 4.57E-16 YML081C-A ATP18 hom Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms