YJR025C / BNA1

3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR025C / BNA1

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:3.25|P-value:7.45E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-4.61|P-value:6.22E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:3.82|P-value:9.81E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.31|P-value:6.17E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.26|P-value:7.20E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.05|P-value:3.98E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.67|P-value:1.71E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.90|P-value:7.27E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.80|P-value:1.63E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.36|P-value:7.61E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.67|P-value:1.74E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.96|P-value:5.78E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:3.21|P-value:8.46E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.39|P-value:9.73E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-5.14|P-value:5.44E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:4.84|P-value:1.28E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.31|P-value:6.15E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.68|P-value:1.81E-8 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.34|P-value:5.50E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.54|P-value:2.80E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.69|P-value:2.62E-6 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.37|P-value:5.00E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.23|P-value:7.92E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.38|P-value:7.21E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.91|P-value:6.86E-5 ID:SGTC_1840|Compound:st055363|FD-Score:3.64|P-value:1.95E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.18|P-value:9.52E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.57|P-value:2.48E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.81|P-value:1.04E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.22|P-value:2.05E-7 ID:SGTC_1950|Compound:st077106|FD-Score:3.49|P-value:3.26E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.21|P-value:8.62E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-4.41|P-value:1.44E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.30|P-value:9.41E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.73|P-value:2.13E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.23|P-value:7.96E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.45|P-value:5.73E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.02|P-value:4.53E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.22|P-value:8.17E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:6.39|P-value:3.08E-10 ID:SGTC_2730|Compound:imipramine|FD-Score:3.25|P-value:7.49E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:4.01|P-value:4.61E-5 ID:SGTC_2906|Compound:7926292|FD-Score:5.54|P-value:3.80E-8 ID:SGTC_3029|Compound:9088683|FD-Score:3.18|P-value:9.38E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.70|P-value:1.53E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.80|P-value:1.63E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.24|P-value:7.61E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.89|P-value:1.19E-4 ID:SGTC_3200|Compound:9114385|FD-Score:5.01|P-value:5.68E-7 ID:SGTC_3259|Compound:9138485|FD-Score:3.50|P-value:3.15E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.25|P-value:7.45E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-4.61|P-value:6.22E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:3.82|P-value:9.81E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.31|P-value:6.17E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.26|P-value:7.20E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.05|P-value:3.98E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.67|P-value:1.71E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.90|P-value:7.27E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.80|P-value:1.63E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.36|P-value:7.61E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.67|P-value:1.74E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.96|P-value:5.78E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:3.21|P-value:8.46E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.39|P-value:9.73E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-5.14|P-value:5.44E-7 ID:SGTC_919|Compound:tnp00227|FD-Score:4.84|P-value:1.28E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.31|P-value:6.15E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.68|P-value:1.81E-8 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.34|P-value:5.50E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.54|P-value:2.80E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.69|P-value:2.62E-6 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.37|P-value:5.00E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.23|P-value:7.92E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.38|P-value:7.21E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.91|P-value:6.86E-5 ID:SGTC_1840|Compound:st055363|FD-Score:3.64|P-value:1.95E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.18|P-value:9.52E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.57|P-value:2.48E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.81|P-value:1.04E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.22|P-value:2.05E-7 ID:SGTC_1950|Compound:st077106|FD-Score:3.49|P-value:3.26E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.21|P-value:8.62E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-4.41|P-value:1.44E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.30|P-value:9.41E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.73|P-value:2.13E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.23|P-value:7.96E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.45|P-value:5.73E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.02|P-value:4.53E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.22|P-value:8.17E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:6.39|P-value:3.08E-10 ID:SGTC_2730|Compound:imipramine|FD-Score:3.25|P-value:7.49E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:4.01|P-value:4.61E-5 ID:SGTC_2906|Compound:7926292|FD-Score:5.54|P-value:3.80E-8 ID:SGTC_3029|Compound:9088683|FD-Score:3.18|P-value:9.38E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.70|P-value:1.53E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.80|P-value:1.63E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.24|P-value:7.61E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.89|P-value:1.19E-4 ID:SGTC_3200|Compound:9114385|FD-Score:5.01|P-value:5.68E-7 ID:SGTC_3259|Compound:9138485|FD-Score:3.50|P-value:3.15E-4

Top fitness defect scores for YJR025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2638 epoxomicin 6.39 18.0 µM 3.08E-10 6 8.55E-11
2 SGTC_1076 itraconazole 5.68 331.0 nM 1.81E-8 10 6.76E-9
3 SGTC_2906 7926292 5.54 26.4 µM 3.80E-8 8 1.50E-8
4 SGTC_1936 st074407 5.22 74.3 µM 2.05E-7 DNA damage response 10 9.13E-8
5 SGTC_3200 9114385 5.01 49.5 µM 5.68E-7 14 2.71E-7
6 SGTC_919 tnp00227 4.84 403.6 nM 1.28E-6 RNA pol III & RNase P/MRP 14 6.48E-7
7 SGTC_1203 3992-3522 4.69 103.0 µM 2.62E-6 13 1.40E-6
8 SGTC_806 3966-4455 4.39 5.9 µM 9.73E-6 12 5.66E-6
9 SGTC_277 nystatin 4.05 15.5 µM 3.98E-5 11 2.54E-5
10 SGTC_2517 totarol 4.02 10.0 µM 4.53E-5 17 2.92E-5
11 SGTC_2742 clothiapine 4.01 36.3 µM 4.61E-5 NEO1 9 2.98E-5
12 SGTC_621 3584-0052 3.96 32.1 µM 5.78E-5 26 3.79E-5
13 SGTC_1824 st053723 3.91 68.6 µM 6.86E-5 34 4.55E-5
14 SGTC_417 st075190 3.90 100.0 µM 7.27E-5 10 4.84E-5
15 SGTC_165 k038-0023 3.82 64.4 µM 9.81E-5 ubiquinone biosynthesis & proteasome 87 6.66E-5
16 SGTC_1930 st074634 3.81 34.3 µM 1.04E-4 RNA pol III & RNase P/MRP 40 7.06E-5
17 SGTC_3084 9116877 3.70 49.5 µM 1.53E-4 9 1.07E-4
18 SGTC_416 estradiol valerate 3.67 100.0 µM 1.71E-4 20 1.21E-4
19 SGTC_572 0960-0087 3.67 17.7 µM 1.74E-4 34 1.23E-4
20 SGTC_1840 st055363 3.64 71.0 µM 1.95E-4 18 1.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.60E-13 YDR014W RAD61 hom Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin
0.105 1.03E-9 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.105 1.08E-9 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
0.100 6.13E-9 YIR002C MPH1 hom 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases
0.090 2.06E-7 YGR024C THG1 het tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
0.089 2.13E-7 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.089 2.50E-7 YLR455W YLR455W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress
0.088 3.44E-7 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.086 5.73E-7 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.084 1.19E-6 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.084 1.28E-6 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.083 1.31E-6 YGR068C ART5 hom Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane
0.083 1.65E-6 YOL037C_d YOL037C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
0.079 4.17E-6 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.078 6.77E-6 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication