YJR046W / TAH11

DNA replication licensing factor, required for pre-replication complex assembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR046W / TAH11

Click on Significant Values for Screen Details ID:SGTC_462|Compound:ag-879|FD-Score:-3.29|P-value:7.55E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.49|P-value:4.96E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:-3.24|P-value:9.11E-4 ID:SGTC_1674|Compound:st016616|FD-Score:5.03|P-value:9.20E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:3.80|P-value:1.62E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.59|P-value:3.46E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-4.10|P-value:4.09E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-3.29|P-value:7.55E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.49|P-value:4.96E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:-3.24|P-value:9.11E-4 ID:SGTC_1674|Compound:st016616|FD-Score:5.03|P-value:9.20E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:3.80|P-value:1.62E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.59|P-value:3.46E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-4.10|P-value:4.09E-5

Top fitness defect scores for YJR046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1674 st016616 5.03 23.6 µM 9.20E-7 3 2.40E-7 0.42
2 SGTC_2607 solasodine 3.80 47.4 µM 1.62E-4 13 7.17E-5 0.04
3 SGTC_2615 purpurogallin-4-carboxylic acid 3.59 100.0 µM 3.46E-4 redox potentiating 11 1.65E-4 0.00
4 SGTC_480 am 92016 3.49 50.0 µM 4.96E-4 13 2.46E-4 0.10
5 SGTC_6 0844-0013 3.24 19.8 µM 0.00110 22 5.92E-4 0.06
6 SGTC_123 0083-0120 3.19 66.7 µM 0.00129 22 7.08E-4 0.02
7 SGTC_1373 2887-0003 3.14 58.5 µM 0.00153 Golgi 28 8.52E-4 0.08
8 SGTC_120 rhodamine 6G 3.10 52.3 µM 0.00173 mitochondrial processes 39 9.75E-4 0.04
9 SGTC_1234 0326-0494 3.03 15.5 µM 0.00214 14 0.00123 0.07
10 SGTC_2581 avocatin a 3.01 64.0 µM 0.00229 sphingolipid biosynthesis & PDR1 18 0.00132 0.10
11 SGTC_597 k018-0003 3.00 82.8 µM 0.00232 RNA pol III & RNase P/MRP 13 0.00134 0.10
12 SGTC_1308 1187-1617 2.99 41.4 µM 0.00241 fatty acid desaturase (OLE1) 28 0.00140 0.05
13 SGTC_1197 1601-0112 2.95 267.0 µM 0.00270 15 0.00159 0.03
14 SGTC_1911 st060208 2.91 74.3 µM 0.00299 17 0.00178 0.07
15 SGTC_573 3702-0553 2.91 84.7 µM 0.00307 16 0.00183 0.07
16 SGTC_2039 Aminomethylbenzodioxan 2.88 200.0 µM 0.00332 15 0.00200 0.12
17 SGTC_2117 5521686 2.86 200.0 µM 0.00350 13 0.00212 0.01
18 SGTC_1993 st073995 2.82 70.8 µM 0.00393 18 0.00240 0.01
19 SGTC_2962 9082311 2.77 13.2 µM 0.00455 29 0.00282 0.03
20 SGTC_1193 1488-0126 2.76 41.5 µM 0.00460 15 0.00286 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.44E-29 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.189 2.55E-28 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.170 4.98E-23 YJR037W_d YJR037W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces
0.165 5.95E-22 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.154 3.31E-19 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.150 2.49E-18 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.148 6.23E-18 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.140 4.52E-16 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.135 4.83E-15 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.133 8.71E-15 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.131 2.13E-14 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.126 2.39E-13 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.125 3.61E-13 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.120 2.90E-12 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.119 3.99E-12 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis