HIPHOP chemogenomics database

YJR048W / CYC1

Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YJR048W / CYC1

Click on Significant Values for Screen Details

Top fitness defect scores for YJR048W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	9.29	5.3 µM	8.81E-26		208	7.92E-21
2	SGTC_1424	4048-1941	6.53	275.0 µM	1.05E-13		4	3.28E-11
3	SGTC_2393	9031399	5.51	185.9 µM	2.90E-10	RNA processing & uracil transport	8	1.82E-8
4	SGTC_1577	3(2'-chlorophenyl)-7-ethoxycoumarin	5.17	66.5 µM	3.09E-9		5	1.20E-7
5	SGTC_2128	5255449	4.98	168.5 µM	1.07E-8		11	3.23E-7
6	SGTC_1433	4060-0023	4.83	7.6 µM	2.65E-8	tubulin folding & SWR complex	11	6.67E-7
7	SGTC_1635	st007035	4.47	42.4 µM	2.47E-7		185	3.97E-6
8	SGTC_3293	9120939	4.40	62.0 µM	3.56E-7		10	5.32E-6
9	SGTC_1446	4239-0190	4.15	62.0 µM	1.46E-6		31	1.65E-5
10	SGTC_2851	9015922	4.01	71.4 µM	3.14E-6		34	3.03E-5
11	SGTC_1367	1812-0510	3.94	76.9 µM	4.62E-6		21	4.14E-5
12	SGTC_1934	st074720	3.89	32.6 µM	5.78E-6		60	4.95E-5
13	SGTC_1322	1348-1070	3.72	12.0 µM	1.37E-5		7	9.86E-5
14	SGTC_2753	fluvastatin	3.64	17.1 µM	2.06E-5	azole & statin	49	1.37E-4
15	SGTC_2831	7999036	3.63	19.5 µM	2.11E-5		56	1.40E-4
16	SGTC_990	3985-0011	3.41	41.3 µM	6.11E-5	amide catabolism	34	3.28E-4
17	SGTC_2595	hexamethylquercetagetin	3.40	100.0 µM	6.27E-5		48	3.34E-4
18	SGTC_1945	st075991	3.40	56.6 µM	6.33E-5	60S ribosome export	38	3.37E-4
19	SGTC_355	1311-2252	3.38	105.0 µM	6.98E-5		42	3.64E-4
20	SGTC_1855	st056195	3.38	39.6 µM	7.05E-5	60S ribosome export	35	3.67E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.367	7.53E-108	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.354	1.58E-99	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.353	4.24E-99	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.336	3.95E-89	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.321	3.92E-81	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.318	9.99E-80	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.312	6.16E-77	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.312	1.55E-76	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.310	1.22E-75	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.303	4.22E-72	YGR112W	SHY1	hom	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.300	8.99E-71	YKL087C	CYT2	hom	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.299	2.61E-70	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.298	1.01E-69	YKL208W	CBT1	hom	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
0.296	9.41E-69	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.293	3.09E-67	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex