YJR048W / CYC1

Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR048W / CYC1

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:9.29|P-value:8.81E-26 ID:SGTC_266|Compound:formosanin C|FD-Score:3.31|P-value:9.58E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.38|P-value:6.98E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:-2.98|P-value:4.47E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-3.08|P-value:3.07E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.01|P-value:3.44E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.09|P-value:2.89E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.13|P-value:2.11E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.27|P-value:1.11E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.95|P-value:4.38E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.41|P-value:6.11E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.79|P-value:8.11E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:2.86|P-value:6.26E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:2.79|P-value:8.32E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.80|P-value:7.77E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.82|P-value:8.49E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:2.79|P-value:8.20E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.72|P-value:1.37E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:-2.85|P-value:7.39E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.06|P-value:2.77E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.94|P-value:4.62E-6 ID:SGTC_1424|Compound:4048-1941|FD-Score:6.53|P-value:1.05E-13 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.07|P-value:2.69E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.83|P-value:2.65E-8 ID:SGTC_1437|Compound:4092-1038|FD-Score:2.80|P-value:7.88E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.32|P-value:1.09E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.15|P-value:1.46E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.82|P-value:7.42E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:5.17|P-value:3.09E-9 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.06|P-value:3.32E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.47|P-value:2.47E-7 ID:SGTC_1717|Compound:st033143|FD-Score:2.76|P-value:9.01E-4 ID:SGTC_1762|Compound:st045503|FD-Score:2.97|P-value:4.07E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.38|P-value:7.05E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.89|P-value:5.78E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.40|P-value:6.33E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-2.91|P-value:5.90E-4 ID:SGTC_2029|Compound:5175081|FD-Score:2.88|P-value:5.83E-4 ID:SGTC_2066|Compound:5222451|FD-Score:2.93|P-value:4.77E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-2.81|P-value:8.76E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.98|P-value:1.07E-8 ID:SGTC_2257|Compound:7960413|FD-Score:2.87|P-value:6.08E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-2.84|P-value:7.85E-4 ID:SGTC_2393|Compound:9031399|FD-Score:5.51|P-value:2.90E-10 ID:SGTC_2400|Compound:5203494|FD-Score:-3.53|P-value:4.23E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-5.03|P-value:9.70E-9 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.53|P-value:2.19E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.40|P-value:6.27E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.64|P-value:2.06E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.43|P-value:6.60E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.63|P-value:2.11E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.10|P-value:2.78E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-2.89|P-value:6.33E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.01|P-value:3.14E-6 ID:SGTC_2873|Compound:9040596|FD-Score:2.77|P-value:8.87E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.06|P-value:3.28E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-2.94|P-value:5.23E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.34|P-value:8.36E-5 ID:SGTC_3056|Compound:9094900|FD-Score:2.76|P-value:9.20E-4 ID:SGTC_3188|Compound:9110789|FD-Score:2.92|P-value:4.96E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.99|P-value:4.23E-6 ID:SGTC_3293|Compound:9120939|FD-Score:4.40|P-value:3.56E-7 ID:SGTC_3310|Compound:9130229|FD-Score:-3.12|P-value:2.52E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.29|P-value:8.81E-26 ID:SGTC_266|Compound:formosanin C|FD-Score:3.31|P-value:9.58E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.38|P-value:6.98E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:-2.98|P-value:4.47E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-3.08|P-value:3.07E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.01|P-value:3.44E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.09|P-value:2.89E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.13|P-value:2.11E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.27|P-value:1.11E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.95|P-value:4.38E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.41|P-value:6.11E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.79|P-value:8.11E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:2.86|P-value:6.26E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:2.79|P-value:8.32E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.80|P-value:7.77E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.82|P-value:8.49E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:2.79|P-value:8.20E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.72|P-value:1.37E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:-2.85|P-value:7.39E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.06|P-value:2.77E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.94|P-value:4.62E-6 ID:SGTC_1424|Compound:4048-1941|FD-Score:6.53|P-value:1.05E-13 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.07|P-value:2.69E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:4.83|P-value:2.65E-8 ID:SGTC_1437|Compound:4092-1038|FD-Score:2.80|P-value:7.88E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.32|P-value:1.09E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.15|P-value:1.46E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.82|P-value:7.42E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:5.17|P-value:3.09E-9 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.06|P-value:3.32E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.47|P-value:2.47E-7 ID:SGTC_1717|Compound:st033143|FD-Score:2.76|P-value:9.01E-4 ID:SGTC_1762|Compound:st045503|FD-Score:2.97|P-value:4.07E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.38|P-value:7.05E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.89|P-value:5.78E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.40|P-value:6.33E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-2.91|P-value:5.90E-4 ID:SGTC_2029|Compound:5175081|FD-Score:2.88|P-value:5.83E-4 ID:SGTC_2066|Compound:5222451|FD-Score:2.93|P-value:4.77E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-2.81|P-value:8.76E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.98|P-value:1.07E-8 ID:SGTC_2257|Compound:7960413|FD-Score:2.87|P-value:6.08E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-2.84|P-value:7.85E-4 ID:SGTC_2393|Compound:9031399|FD-Score:5.51|P-value:2.90E-10 ID:SGTC_2400|Compound:5203494|FD-Score:-3.53|P-value:4.23E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-5.03|P-value:9.70E-9 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.53|P-value:2.19E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.40|P-value:6.27E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.64|P-value:2.06E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.43|P-value:6.60E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.63|P-value:2.11E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.10|P-value:2.78E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-2.89|P-value:6.33E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.01|P-value:3.14E-6 ID:SGTC_2873|Compound:9040596|FD-Score:2.77|P-value:8.87E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.06|P-value:3.28E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-2.94|P-value:5.23E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.34|P-value:8.36E-5 ID:SGTC_3056|Compound:9094900|FD-Score:2.76|P-value:9.20E-4 ID:SGTC_3188|Compound:9110789|FD-Score:2.92|P-value:4.96E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.99|P-value:4.23E-6 ID:SGTC_3293|Compound:9120939|FD-Score:4.40|P-value:3.56E-7 ID:SGTC_3310|Compound:9130229|FD-Score:-3.12|P-value:2.52E-4

Top fitness defect scores for YJR048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.29 5.3 µM 8.81E-26 208 7.92E-21
2 SGTC_1424 4048-1941 6.53 275.0 µM 1.05E-13 4 3.28E-11
3 SGTC_2393 9031399 5.51 185.9 µM 2.90E-10 RNA processing & uracil transport 8 1.82E-8
4 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 5.17 66.5 µM 3.09E-9 5 1.20E-7
5 SGTC_2128 5255449 4.98 168.5 µM 1.07E-8 11 3.23E-7
6 SGTC_1433 4060-0023 4.83 7.6 µM 2.65E-8 tubulin folding & SWR complex 11 6.67E-7
7 SGTC_1635 st007035 4.47 42.4 µM 2.47E-7 185 3.97E-6
8 SGTC_3293 9120939 4.40 62.0 µM 3.56E-7 10 5.32E-6
9 SGTC_1446 4239-0190 4.15 62.0 µM 1.46E-6 31 1.65E-5
10 SGTC_2851 9015922 4.01 71.4 µM 3.14E-6 34 3.03E-5
11 SGTC_1367 1812-0510 3.94 76.9 µM 4.62E-6 21 4.14E-5
12 SGTC_1934 st074720 3.89 32.6 µM 5.78E-6 60 4.95E-5
13 SGTC_1322 1348-1070 3.72 12.0 µM 1.37E-5 7 9.86E-5
14 SGTC_2753 fluvastatin 3.64 17.1 µM 2.06E-5 azole & statin 49 1.37E-4
15 SGTC_2831 7999036 3.63 19.5 µM 2.11E-5 56 1.40E-4
16 SGTC_990 3985-0011 3.41 41.3 µM 6.11E-5 amide catabolism 34 3.28E-4
17 SGTC_2595 hexamethylquercetagetin 3.40 100.0 µM 6.27E-5 48 3.34E-4
18 SGTC_1945 st075991 3.40 56.6 µM 6.33E-5 60S ribosome export 38 3.37E-4
19 SGTC_355 1311-2252 3.38 105.0 µM 6.98E-5 42 3.64E-4
20 SGTC_1855 st056195 3.38 39.6 µM 7.05E-5 60S ribosome export 35 3.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.367 7.53E-108 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.354 1.58E-99 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.353 4.24E-99 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.336 3.95E-89 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.321 3.92E-81 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.318 9.99E-80 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.312 6.16E-77 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.312 1.55E-76 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.310 1.22E-75 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.303 4.22E-72 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.300 8.99E-71 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.299 2.61E-70 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.298 1.01E-69 YKL208W CBT1 hom Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
0.296 9.41E-69 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.293 3.09E-67 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex