YJR052W / RAD7

Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR052W / RAD7

Click on Significant Values for Screen Details ID:SGTC_237|Compound:nikkomycin|FD-Score:3.41|P-value:2.33E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.89|P-value:3.19E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.16|P-value:5.15E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.19|P-value:5.23E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.74|P-value:5.94E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.14|P-value:5.53E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.34|P-value:2.68E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.98|P-value:9.96E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.12|P-value:5.90E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.04|P-value:9.03E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.24|P-value:4.45E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:8.71E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.94|P-value:2.15E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.45|P-value:2.01E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.08|P-value:6.93E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-4.28|P-value:4.62E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-2.99|P-value:9.57E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.47|P-value:1.57E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.07|P-value:8.92E-8 ID:SGTC_2958|Compound:9077254|FD-Score:-4.25|P-value:5.26E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-10.00|P-value:1.82E-25 ID:SGTC_2964|Compound:9083345|FD-Score:-4.95|P-value:1.44E-7 ID:SGTC_2978|Compound:9011784|FD-Score:3.84|P-value:3.95E-5 ID:SGTC_2986|Compound:9022445|FD-Score:-3.30|P-value:3.03E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.45|P-value:1.70E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.73|P-value:6.34E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.24|P-value:4.41E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.15|P-value:5.39E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.41|P-value:2.33E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.89|P-value:3.19E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.16|P-value:5.15E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.19|P-value:5.23E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.74|P-value:5.94E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.14|P-value:5.53E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.34|P-value:2.68E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.98|P-value:9.96E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.12|P-value:5.90E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.04|P-value:9.03E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.24|P-value:4.45E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:8.71E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.94|P-value:2.15E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.45|P-value:2.01E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.08|P-value:6.93E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-4.28|P-value:4.62E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-2.99|P-value:9.57E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.47|P-value:1.57E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.43|P-value:2.13E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.07|P-value:8.92E-8 ID:SGTC_2958|Compound:9077254|FD-Score:-4.25|P-value:5.26E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-10.00|P-value:1.82E-25 ID:SGTC_2964|Compound:9083345|FD-Score:-4.95|P-value:1.44E-7 ID:SGTC_2978|Compound:9011784|FD-Score:3.84|P-value:3.95E-5 ID:SGTC_2986|Compound:9022445|FD-Score:-3.30|P-value:3.03E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.45|P-value:1.70E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.73|P-value:6.34E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.24|P-value:4.41E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.15|P-value:5.39E-4

Top fitness defect scores for YJR052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2757 clomiphene 5.07 4.2 µM 8.92E-8 fatty acid desaturase (OLE1) 18 1.95E-7
2 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.89 44.4 nM 3.19E-5 DNA damage response 31 5.01E-5
3 SGTC_2978 9011784 3.84 43.0 µM 3.95E-5 32 6.14E-5
4 SGTC_375 3970-0961 3.74 9.3 µM 5.94E-5 tubulin folding & SWR complex 25 9.02E-5
5 SGTC_3146 9095609 3.73 49.5 µM 6.34E-5 20 9.59E-5
6 SGTC_1262 0737-0114 3.65 49.6 µM 8.71E-5 26 1.30E-4
7 SGTC_1445 4239-0156 3.45 97.7 µM 2.01E-4 47 2.85E-4
8 SGTC_2546 rhodinyl acetate 3.43 100.0 µM 2.13E-4 23 3.01E-4
9 SGTC_237 nikkomycin 3.41 200.0 µM 2.33E-4 RSC complex & mRNA processing 32 3.28E-4
10 SGTC_3147 9097027 3.24 49.5 µM 4.41E-4 53 6.00E-4
11 SGTC_1229 0139-0193 3.24 12.2 µM 4.45E-4 RSC complex & mRNA processing 34 6.05E-4
12 SGTC_364 0083-0097 3.19 67.7 µM 5.23E-4 55 7.06E-4
13 SGTC_774 k060-0086 3.04 136.0 µM 9.03E-4 54 0.00118
14 SGTC_1631 benzylvanillin 2.96 81.9 µM 0.00118 Golgi 78 0.00153
15 SGTC_2536 dehydroabietamide 2.93 32.0 µM 0.00134 102 0.00172
16 SGTC_2585 alliin 2.92 100.0 µM 0.00136 87 0.00174
17 SGTC_2480 5767542 2.91 37.2 µM 0.00141 52 0.00180
18 SGTC_909 3448-9333 2.88 149.0 µM 0.00154 56 0.00197
19 SGTC_3063 1327-0034 2.86 4.0 µM 0.00166 87 0.00211
20 SGTC_436 n,n-dimethylsphingosine 2.83 3.3 µM 0.00183 81 0.00231

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.18E-36 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.195 5.68E-30 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.168 1.20E-22 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.161 6.06E-21 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.157 6.06E-20 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.153 5.25E-19 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.138 9.55E-16 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.137 1.48E-15 YPR056W TFB4 het Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
0.129 6.60E-14 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.128 1.06E-13 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.124 6.39E-13 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.121 2.46E-12 YLR250W SSP120 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.111 1.23E-10 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.106 6.50E-10 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.105 1.01E-9 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif