YJR066W / TOR1

PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR066W / TOR1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.46|P-value:8.14E-7 ID:SGTC_51|Compound:1013-0126|FD-Score:4.77|P-value:1.50E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:4.45|P-value:8.65E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:4.69|P-value:2.44E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.40|P-value:1.27E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.91|P-value:1.56E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.41|P-value:1.22E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.78|P-value:2.37E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:4.21|P-value:3.07E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:4.73|P-value:1.89E-7 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.03|P-value:6.40E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-2.95|P-value:8.69E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.88|P-value:9.73E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:5.43|P-value:2.74E-9 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.41|P-value:1.23E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.37|P-value:1.47E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.45|P-value:1.02E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.01|P-value:6.08E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.35|P-value:1.58E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.29|P-value:1.97E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.96|P-value:4.98E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:23.50|P-value:3.26E-140 ID:SGTC_1873|Compound:rapamycin|FD-Score:13.00|P-value:1.42E-44 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.59|P-value:9.86E-10 ID:SGTC_1903|Compound:st060211|FD-Score:4.11|P-value:4.94E-6 ID:SGTC_1908|Compound:st060353|FD-Score:5.23|P-value:9.75E-9 ID:SGTC_1943|Compound:st076331|FD-Score:-3.19|P-value:3.48E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-3.45|P-value:1.20E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.25|P-value:2.47E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.52|P-value:7.56E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.24|P-value:2.50E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.31|P-value:1.88E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.22|P-value:2.68E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.28|P-value:2.13E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.27|P-value:2.52E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.20|P-value:2.91E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.19|P-value:3.00E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.53|P-value:7.47E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.04|P-value:6.25E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.22|P-value:2.88E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.90|P-value:1.45E-43 ID:SGTC_2799|Compound:7812892|FD-Score:3.25|P-value:2.38E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.30|P-value:2.25E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.49|P-value:8.82E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.13|P-value:4.32E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.18|P-value:3.57E-4 ID:SGTC_3009|Compound:9080819|FD-Score:2.91|P-value:8.74E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.10|P-value:4.86E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.46|P-value:8.14E-7 ID:SGTC_51|Compound:1013-0126|FD-Score:4.77|P-value:1.50E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:4.45|P-value:8.65E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:4.69|P-value:2.44E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.40|P-value:1.27E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.91|P-value:1.56E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.41|P-value:1.22E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.78|P-value:2.37E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:4.21|P-value:3.07E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:4.73|P-value:1.89E-7 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.03|P-value:6.40E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-2.95|P-value:8.69E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.88|P-value:9.73E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:5.43|P-value:2.74E-9 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.41|P-value:1.23E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.37|P-value:1.47E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.45|P-value:1.02E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.01|P-value:6.08E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.35|P-value:1.58E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.29|P-value:1.97E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.96|P-value:4.98E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:23.50|P-value:3.26E-140 ID:SGTC_1873|Compound:rapamycin|FD-Score:13.00|P-value:1.42E-44 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.59|P-value:9.86E-10 ID:SGTC_1903|Compound:st060211|FD-Score:4.11|P-value:4.94E-6 ID:SGTC_1908|Compound:st060353|FD-Score:5.23|P-value:9.75E-9 ID:SGTC_1943|Compound:st076331|FD-Score:-3.19|P-value:3.48E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-3.45|P-value:1.20E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.25|P-value:2.47E-6 ID:SGTC_2004|Compound:4023728|FD-Score:3.52|P-value:7.56E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.24|P-value:2.50E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.31|P-value:1.88E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.22|P-value:2.68E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.28|P-value:2.13E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.27|P-value:2.52E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.20|P-value:2.91E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.19|P-value:3.00E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.53|P-value:7.47E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.04|P-value:6.25E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.22|P-value:2.88E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.90|P-value:1.45E-43 ID:SGTC_2799|Compound:7812892|FD-Score:3.25|P-value:2.38E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.30|P-value:2.25E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.49|P-value:8.82E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.13|P-value:4.32E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.18|P-value:3.57E-4 ID:SGTC_3009|Compound:9080819|FD-Score:2.91|P-value:8.74E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.10|P-value:4.86E-4

Top fitness defect scores for YJR066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 23.50 4.0 nM 3.26E-140 3 1.13E-122
2 SGTC_1873 rapamycin 13.00 2.0 nM 1.42E-44 2 4.09E-39
3 SGTC_2679 rapamycin 12.90 1.0 nM 1.45E-43 10 3.11E-38
4 SGTC_1877 wortmannin 5.59 25.0 µM 9.86E-10 52 1.13E-8
5 SGTC_1418 3966-3099 5.43 2.4 µM 2.74E-9 6 2.76E-8
6 SGTC_1908 st060353 5.23 56.5 µM 9.75E-9 RPP1 & pyrimidine depletion 18 8.38E-8
7 SGTC_1781 st038725 4.96 66.3 µM 4.98E-8 NEO1 74 3.49E-7
8 SGTC_51 1013-0126 4.77 23.4 µM 1.50E-7 21 9.16E-7
9 SGTC_822 1487-0950 4.73 154.0 µM 1.89E-7 5 1.12E-6
10 SGTC_68 0986-0284 4.69 82.8 µM 2.44E-7 42 1.40E-6
11 SGTC_39 0986-0283 4.46 58.4 µM 8.14E-7 calcium & mitochondrial duress 22 4.02E-6
12 SGTC_59 0330-0160 4.45 1.3 µM 8.65E-7 87 4.24E-6
13 SGTC_2003 4023581 4.25 200.0 µM 2.47E-6 cell wall signaling 29 1.06E-5
14 SGTC_2620 irigenin 4.22 100.0 µM 2.88E-6 29 1.22E-5
15 SGTC_779 1360-0071 4.21 233.0 µM 3.07E-6 fatty acid desaturase (OLE1) 22 1.29E-5
16 SGTC_1903 st060211 4.11 78.3 µM 4.94E-6 21 1.95E-5
17 SGTC_768 0384-0033 3.78 77.3 µM 2.37E-5 fatty acid desaturase (OLE1) 89 7.71E-5
18 SGTC_2518 prenyletin 3.53 46.3 µM 7.47E-5 17 2.11E-4
19 SGTC_2004 4023728 3.52 41.9 µM 7.56E-5 39 2.13E-4
20 SGTC_2959 9079155 3.49 11.0 µM 8.82E-5 43 2.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.583 1.33E-304 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.565 2.74E-282 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.498 4.30E-210 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.439 5.78E-158 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.418 1.80E-142 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.412 1.87E-137 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.372 1.90E-110 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.369 8.51E-109 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.366 7.35E-107 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.350 4.90E-97 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.343 1.69E-92 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.341 1.32E-91 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.340 1.11E-91 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.319 3.35E-80 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.294 5.52E-68 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source