HIPHOP chemogenomics database

YJR074W / MOG1

Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p

Zygosity: Homozygous strain

fixedexpanded
Profile for YJR074W / MOG1

Click on Significant Values for Screen Details

Top fitness defect scores for YJR074W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1287	0971-0001	13.90	34.6 µM	9.35E-41	sphingolipid biosynthesis & PDR1	6	4.03E-44
2	SGTC_168	3970-0862	8.98	530.5 µM	3.25E-18		14	1.35E-19
3	SGTC_1687	st020778	8.21	55.4 µM	1.60E-15		67	1.14E-16
4	SGTC_3200	9114385	8.13	49.5 µM	2.94E-15		2	2.21E-16
5	SGTC_1854	st056233	7.01	32.9 µM	8.07E-12	amide catabolism	2	1.19E-12
6	SGTC_2651	1327-0036	6.81	5.0 µM	2.92E-11		50	4.81E-12
7	SGTC_2858	9025781	5.98	9.0 µM	4.31E-9	sphingolipid biosynthesis & PDR1	46	1.09E-9
8	SGTC_2141	5621638	5.41	7.7 µM	9.86E-8	tubulin folding & SWR complex	15	3.23E-8
9	SGTC_150	3970-0969	5.40	77.2 µM	1.01E-7		29	3.32E-8
10	SGTC_2290	7904846	5.37	200.0 µM	1.17E-7		6	3.89E-8
11	SGTC_2322	7413319	5.37	38.2 µM	1.19E-7	ERAD & cell cycle	79	3.95E-8
12	SGTC_214	4373-3496	5.23	70.0 µM	2.39E-7		23	8.42E-8
13	SGTC_159	3970-0959	5.16	50.0 µM	3.40E-7		35	1.23E-7
14	SGTC_2089	5281248	5.14	129.7 µM	3.82E-7	superoxide	8	1.40E-7
15	SGTC_3091	9116372	4.93	49.5 µM	1.04E-6		5	4.13E-7
16	SGTC_1288	0973-0013	4.65	65.5 µM	3.73E-6		9	1.65E-6
17	SGTC_588	3970-1144	4.45	52.9 µM	9.16E-6		19	4.35E-6
18	SGTC_241	5hr heat shock (37°C) + cantharidin	4.44	155.4 µM	9.54E-6	cell wall signaling	60	4.55E-6
19	SGTC_1547	harmine	4.44	94.2 µM	9.65E-6	ergosterol biosynthesis	30	4.60E-6
20	SGTC_528	3492-0019	4.42	172.0 µM	1.03E-5	calcium & mitochondrial duress	187	4.93E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.298	6.18E-70	YGR164W_d	YGR164W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.295	4.49E-68	YMR031W-A_d	YMR031W-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.290	3.64E-66	YBL079W	NUP170	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.279	8.45E-61	YLR055C	SPT8	hom	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.259	1.23E-52	YDR120C	TRM1	hom	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.255	4.51E-51	YLR204W	QRI5	hom	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.228	1.22E-40	YDR392W	SPT3	hom	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.215	1.65E-36	YNL235C_d	YNL235C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
0.212	2.11E-35	YNL237W	YTP1	hom	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.210	7.23E-35	YLR087C	CSF1	hom	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.210	1.20E-34	YDR069C	DOA4	hom	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.200	2.26E-31	YJL101C	GSH1	hom	Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.193	1.57E-29	YOL050C_d	YOL050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.180	9.31E-26	YLR027C	AAT2	hom	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.173	6.87E-24	YDR495C	VPS3	hom	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase