HIPHOP chemogenomics database

YJR075W / HOC1

Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele

Zygosity: Homozygous strain

fixedexpanded
Profile for YJR075W / HOC1

Click on Significant Values for Screen Details

Top fitness defect scores for YJR075W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3037	9091026	10.30	49.5 µM	2.37E-28	NEO1-PIK1	4	4.03E-25
2	SGTC_2009	4012297	9.48	12.1 µM	2.39E-24	cell wall signaling	9	1.32E-21
3	SGTC_2007	4011539	8.55	71.8 µM	3.47E-20	cell wall signaling	16	5.99E-18
4	SGTC_214	4373-3496	4.97	70.0 µM	5.78E-8		30	3.36E-7
5	SGTC_212	3807-4682	4.94	38.8 µM	6.73E-8	tubulin folding & SWR complex	38	3.84E-7
6	SGTC_625	k213-0058	4.86	121.0 µM	1.09E-7	translation	61	5.89E-7
7	SGTC_3308	9128332	4.69	17.6 µM	2.90E-7	plasma membrane duress	54	1.39E-6
8	SGTC_3152	9099253	4.64	49.5 µM	3.67E-7	NEO1-PIK1	94	1.71E-6
9	SGTC_914	3820-6779	4.45	408.0 µM	1.06E-6		13	4.35E-6
10	SGTC_3188	9110789	4.36	49.5 µM	1.69E-6	iron homeostasis	14	6.61E-6
11	SGTC_2057	5236571	4.28	38.3 µM	2.51E-6	RPP1 & pyrimidine depletion	22	9.33E-6
12	SGTC_3153	9100258	4.17	49.5 µM	4.27E-6		14	1.49E-5
13	SGTC_146	3448-8650	4.17	53.1 µM	4.40E-6	NEO1-PIK1	124	1.53E-5
14	SGTC_663	1486-0733	4.14	13.9 µM	5.00E-6	cell wall signaling	45	1.72E-5
15	SGTC_2896	9052656	3.98	71.4 µM	1.10E-5	endomembrane recycling	112	3.45E-5
16	SGTC_2848	9016370	3.91	26.0 µM	1.51E-5		25	4.55E-5
17	SGTC_2011	4012611	3.86	177.0 µM	1.89E-5	mitochondrial processes	35	5.56E-5
18	SGTC_1568	digitonin	3.85	820.0 nM	2.06E-5	sphingolipid biosynthesis & PDR1	36	5.98E-5
19	SGTC_2055	5235184	3.81	200.0 µM	2.38E-5	ERG2	39	6.82E-5
20	SGTC_2399	5884133	3.79	200.0 µM	2.72E-5	cell wall signaling	79	7.67E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.263	4.96E-54	YGR196C	FYV8	hom	Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.253	2.74E-50	YNL322C	KRE1	hom	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.249	8.85E-49	YAL053W	FLC2	hom	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.234	5.29E-43	YAL056C-A_d	YAL056C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.221	2.23E-38	YAL058W	CNE1	hom	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.203	1.24E-32	YOR085W	OST3	hom	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.197	1.49E-30	YLR332W	MID2	hom	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.196	2.84E-30	YPR041W	TIF5	het	Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.194	7.77E-30	YOR002W	ALG6	hom	Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.192	2.62E-29	YDL203C	ACK1	hom	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.192	3.18E-29	YEL036C	ANP1	hom	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
0.190	1.24E-28	YJL095W	BCK1	hom	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.189	2.28E-28	YNL219C	ALG9	hom	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.187	1.13E-27	YNL084C	END3	hom	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.183	1.21E-26	YNL044W	YIP3	hom	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p