YJR076C / CDC11

Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJR076C / CDC11

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-3.86|P-value:9.11E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.42|P-value:4.66E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.46|P-value:1.92E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.66|P-value:2.03E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.40|P-value:4.89E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.83|P-value:1.07E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.50|P-value:6.84E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-5.13|P-value:3.35E-7 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.87|P-value:8.99E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.23|P-value:2.11E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-3.51|P-value:3.35E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.51|P-value:3.31E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.67|P-value:1.88E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.59|P-value:2.55E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:5.19|P-value:2.51E-7 ID:SGTC_882|Compound:0843-0131|FD-Score:4.39|P-value:1.10E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.53|P-value:3.24E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.71|P-value:1.59E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.26|P-value:8.02E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.24|P-value:8.41E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:-4.87|P-value:1.15E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.31|P-value:1.53E-5 ID:SGTC_1530|Compound:rhein|FD-Score:-3.46|P-value:3.95E-4 ID:SGTC_1531|Compound:st059297|FD-Score:-3.31|P-value:6.53E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.25|P-value:8.11E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.64|P-value:3.50E-6 ID:SGTC_1646|Compound:st011709|FD-Score:-3.39|P-value:5.12E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.83|P-value:1.08E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.28|P-value:7.55E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.78|P-value:1.89E-6 ID:SGTC_1748|Compound:st037455|FD-Score:-4.06|P-value:4.16E-5 ID:SGTC_1794|Compound:st048918|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.41|P-value:4.93E-4 ID:SGTC_1923|Compound:st058458|FD-Score:5.98|P-value:3.55E-9 ID:SGTC_1931|Compound:st074438|FD-Score:3.35|P-value:6.07E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-5.18|P-value:2.59E-7 ID:SGTC_2161|Compound:5662504|FD-Score:-3.73|P-value:1.48E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.92|P-value:7.13E-5 ID:SGTC_2415|Compound:st077333|FD-Score:5.98|P-value:3.51E-9 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.98|P-value:5.74E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.72|P-value:1.57E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.30|P-value:1.55E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.80|P-value:1.69E-6 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.58|P-value:2.64E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.41|P-value:9.90E-6 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.93|P-value:7.16E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.18|P-value:2.67E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.43|P-value:4.45E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.37|P-value:1.20E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:5.16|P-value:2.92E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.17|P-value:2.60E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.24|P-value:8.69E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-6.00|P-value:2.95E-9 ID:SGTC_2687|Compound:chenodiol|FD-Score:-6.88|P-value:1.33E-11 ID:SGTC_2695|Compound:st077686|FD-Score:-4.33|P-value:1.34E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.59|P-value:2.59E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.48|P-value:3.77E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.77|P-value:1.28E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.26|P-value:1.79E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.86|P-value:9.11E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.42|P-value:4.66E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.46|P-value:1.92E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.66|P-value:2.03E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.40|P-value:4.89E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.83|P-value:1.07E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.50|P-value:6.84E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-5.13|P-value:3.35E-7 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.87|P-value:8.99E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.23|P-value:2.11E-5 ID:SGTC_493|Compound:zm226600|FD-Score:-3.51|P-value:3.35E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.51|P-value:3.31E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.67|P-value:1.88E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.59|P-value:2.55E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:5.19|P-value:2.51E-7 ID:SGTC_882|Compound:0843-0131|FD-Score:4.39|P-value:1.10E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.53|P-value:3.24E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.71|P-value:1.59E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.26|P-value:8.02E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.24|P-value:8.41E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:-4.87|P-value:1.15E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.31|P-value:1.53E-5 ID:SGTC_1530|Compound:rhein|FD-Score:-3.46|P-value:3.95E-4 ID:SGTC_1531|Compound:st059297|FD-Score:-3.31|P-value:6.53E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.25|P-value:8.11E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.64|P-value:3.50E-6 ID:SGTC_1646|Compound:st011709|FD-Score:-3.39|P-value:5.12E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.83|P-value:1.08E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.28|P-value:7.55E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.78|P-value:1.89E-6 ID:SGTC_1748|Compound:st037455|FD-Score:-4.06|P-value:4.16E-5 ID:SGTC_1794|Compound:st048918|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.41|P-value:4.93E-4 ID:SGTC_1923|Compound:st058458|FD-Score:5.98|P-value:3.55E-9 ID:SGTC_1931|Compound:st074438|FD-Score:3.35|P-value:6.07E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-5.18|P-value:2.59E-7 ID:SGTC_2161|Compound:5662504|FD-Score:-3.73|P-value:1.48E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.92|P-value:7.13E-5 ID:SGTC_2415|Compound:st077333|FD-Score:5.98|P-value:3.51E-9 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.98|P-value:5.74E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.72|P-value:1.57E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.30|P-value:1.55E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.80|P-value:1.69E-6 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.58|P-value:2.64E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.41|P-value:9.90E-6 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.93|P-value:7.16E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.18|P-value:2.67E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.43|P-value:4.45E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.37|P-value:1.20E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:5.16|P-value:2.92E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.17|P-value:2.60E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.24|P-value:8.69E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-6.00|P-value:2.95E-9 ID:SGTC_2687|Compound:chenodiol|FD-Score:-6.88|P-value:1.33E-11 ID:SGTC_2695|Compound:st077686|FD-Score:-4.33|P-value:1.34E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.59|P-value:2.59E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.48|P-value:3.77E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.77|P-value:1.28E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.26|P-value:1.79E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.83|P-value:1.04E-4

Top fitness defect scores for YJR076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2415 st077333 5.98 57.7 µM 3.51E-9 2 1.09E-9 0.01
2 SGTC_1923 st058458 5.98 19.1 µM 3.55E-9 4 1.10E-9 0.92
3 SGTC_875 0709-0210 5.19 25.7 µM 2.51E-7 fatty acid desaturase (OLE1) 7 1.03E-7 0.30
4 SGTC_2532 xanthone 5.16 78.9 µM 2.92E-7 2 1.21E-7 1.19
5 SGTC_2496 diffractaic acid 4.80 79.8 µM 1.69E-6 1 7.82E-7 0.32
6 SGTC_1675 st018485 4.78 24.5 µM 1.89E-6 60S ribosome export 4 8.85E-7 0.08
7 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 4.64 61.8 µM 3.50E-6 ergosterol biosynthesis 2 1.70E-6 1.14
8 SGTC_340 k038-0059 4.50 454.0 µM 6.84E-6 ubiquinone biosynthesis & proteasome 6 3.47E-6 0.42
9 SGTC_2499 avocadenofuran 4.41 51.5 µM 9.90E-6 2 5.15E-6 0.58
10 SGTC_882 0843-0131 4.39 351.0 µM 1.10E-5 9 5.78E-6 0.17
11 SGTC_2531 methyl deoxycholate 4.37 70.1 µM 1.20E-5 4 6.31E-6 0.50
12 SGTC_1500 4488-1866 4.31 171.0 µM 1.53E-5 RPP1 & pyrimidine depletion 1 8.19E-6 0.39
13 SGTC_412 gemfibrozil 4.23 100.0 µM 2.11E-5 DNA intercalators 4 1.15E-5 0.01
14 SGTC_2504 purpurogallin 4.18 52.3 µM 2.67E-5 RPP1 & pyrimidine depletion 2 1.48E-5 0.07
15 SGTC_2501 sodium tetradecyl sulfate 3.93 13.4 µM 7.16E-5 5 4.23E-5 0.02
16 SGTC_409 arachidonic acid 3.87 100.0 µM 8.99E-5 2 5.39E-5 0.18
17 SGTC_3124 9127567 3.83 49.5 µM 1.04E-4 DNA damage response 6 6.30E-5 0.22
18 SGTC_337 1315-0038 3.83 354.0 µM 1.07E-4 amide catabolism 5 6.50E-5 0.15
19 SGTC_1653 st012112 3.83 65.0 µM 1.08E-4 3 6.52E-5 0.31
20 SGTC_2425 5628681 3.72 7.8 µM 1.57E-4 6 9.77E-5 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.84E-16 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.134 8.07E-15 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.128 9.39E-14 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.113 4.87E-11 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.110 1.92E-10 YDL120W YFH1 het Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
0.109 2.27E-10 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.109 2.31E-10 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.109 2.61E-10 YBR178W_d YBR178W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
0.108 4.26E-10 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.104 1.61E-9 YMR159C ATG16 hom Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.101 4.66E-9 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.101 4.74E-9 YJL173C RFA3 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.091 1.35E-7 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.091 1.51E-7 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.088 3.71E-7 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress