YJR082C / EAF6

Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR082C / EAF6

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.70|P-value:2.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.05|P-value:3.72E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.43|P-value:7.84E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.62|P-value:3.40E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:2.89|P-value:7.43E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.17|P-value:2.41E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.50|P-value:5.91E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:2.93|P-value:6.35E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.08|P-value:3.46E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.09|P-value:3.39E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.51|P-value:5.69E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.96|P-value:5.69E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.19|P-value:1.92E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.18|P-value:2.18E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.80|P-value:1.41E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.99|P-value:4.98E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:2.92|P-value:6.64E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.07|P-value:3.69E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.38|P-value:9.04E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.16|P-value:2.37E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.01|P-value:4.56E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-3.69|P-value:2.24E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:-4.08|P-value:3.24E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-4.99|P-value:1.75E-8 ID:SGTC_1606|Compound:st000094|FD-Score:3.57|P-value:4.25E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.05|P-value:3.97E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.33|P-value:9.00E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:3.13|P-value:2.84E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.57|P-value:4.22E-5 ID:SGTC_1754|Compound:st042065|FD-Score:2.84|P-value:8.86E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.35|P-value:1.04E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:2.86|P-value:8.15E-4 ID:SGTC_1946|Compound:st076057|FD-Score:2.88|P-value:7.69E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.75|P-value:1.83E-5 ID:SGTC_1961|Compound:st076550|FD-Score:3.23|P-value:1.91E-4 ID:SGTC_1967|Compound:st070177|FD-Score:2.85|P-value:8.43E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.08|P-value:3.56E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.25|P-value:1.70E-4 ID:SGTC_2353|Compound:9059630|FD-Score:4.64|P-value:1.61E-7 ID:SGTC_2358|Compound:9037157|FD-Score:4.06|P-value:3.99E-6 ID:SGTC_2401|Compound:5128683|FD-Score:3.17|P-value:2.44E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.80|P-value:4.13E-18 ID:SGTC_2415|Compound:st077333|FD-Score:4.53|P-value:2.98E-7 ID:SGTC_2424|Compound:5537928|FD-Score:-3.36|P-value:1.02E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.91|P-value:6.74E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.94|P-value:6.05E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.38|P-value:9.98E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:6.44|P-value:6.38E-13 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-6.99|P-value:5.59E-15 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.44|P-value:7.01E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.10|P-value:9.54E-9 ID:SGTC_2704|Compound:st078022|FD-Score:3.26|P-value:1.68E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.95|P-value:6.96E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-2.96|P-value:5.27E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.70|P-value:2.11E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.05|P-value:3.72E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.43|P-value:7.84E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.62|P-value:3.40E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:2.89|P-value:7.43E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.17|P-value:2.41E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.50|P-value:5.91E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:2.93|P-value:6.35E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.08|P-value:3.46E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.09|P-value:3.39E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.51|P-value:5.69E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.96|P-value:5.69E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.19|P-value:1.92E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.18|P-value:2.18E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.80|P-value:1.41E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.99|P-value:4.98E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:2.92|P-value:6.64E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.07|P-value:3.69E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.38|P-value:9.04E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.16|P-value:2.37E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.01|P-value:4.56E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-3.69|P-value:2.24E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:-4.08|P-value:3.24E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-4.99|P-value:1.75E-8 ID:SGTC_1606|Compound:st000094|FD-Score:3.57|P-value:4.25E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.05|P-value:3.97E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.33|P-value:9.00E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:3.13|P-value:2.84E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.57|P-value:4.22E-5 ID:SGTC_1754|Compound:st042065|FD-Score:2.84|P-value:8.86E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.35|P-value:1.04E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:2.86|P-value:8.15E-4 ID:SGTC_1946|Compound:st076057|FD-Score:2.88|P-value:7.69E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.75|P-value:1.83E-5 ID:SGTC_1961|Compound:st076550|FD-Score:3.23|P-value:1.91E-4 ID:SGTC_1967|Compound:st070177|FD-Score:2.85|P-value:8.43E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.08|P-value:3.56E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.25|P-value:1.70E-4 ID:SGTC_2353|Compound:9059630|FD-Score:4.64|P-value:1.61E-7 ID:SGTC_2358|Compound:9037157|FD-Score:4.06|P-value:3.99E-6 ID:SGTC_2401|Compound:5128683|FD-Score:3.17|P-value:2.44E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.80|P-value:4.13E-18 ID:SGTC_2415|Compound:st077333|FD-Score:4.53|P-value:2.98E-7 ID:SGTC_2424|Compound:5537928|FD-Score:-3.36|P-value:1.02E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.91|P-value:6.74E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.94|P-value:6.05E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.38|P-value:9.98E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:6.44|P-value:6.38E-13 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-6.99|P-value:5.59E-15 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.44|P-value:7.01E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.10|P-value:9.54E-9 ID:SGTC_2704|Compound:st078022|FD-Score:3.26|P-value:1.68E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.95|P-value:6.96E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-2.96|P-value:5.27E-4

Top fitness defect scores for YJR082C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2409 alverine citrate 7.80 64.0 µM 4.13E-18 10 3.16E-15
2 SGTC_2608 thymoquinone 6.44 42.7 µM 6.38E-13 5 6.01E-11
3 SGTC_2612 dictamnine 5.10 15.5 µM 9.54E-9 RNA pol III & RNase P/MRP 22 1.69E-7
4 SGTC_2353 9059630 4.64 146.7 µM 1.61E-7 12 1.75E-6
5 SGTC_2415 st077333 4.53 57.7 µM 2.98E-7 29 2.91E-6
6 SGTC_1714 st033236 4.33 13.6 µM 9.00E-7 15 7.29E-6
7 SGTC_1214 0358-0031 4.19 63.7 µM 1.92E-6 9 1.37E-5
8 SGTC_2358 9037157 4.06 4.0 µM 3.99E-6 28 2.51E-5
9 SGTC_2777 climbazole 3.95 1.5 µM 6.96E-6 iron homeostasis 53 3.98E-5
10 SGTC_1222 0366-0074 3.80 1.2 µM 1.41E-5 TSC3-RPN4 18 7.16E-5
11 SGTC_1948 st076329 3.75 66.6 µM 1.83E-5 37 8.87E-5
12 SGTC_426 0988-0037 3.62 14.6 µM 3.40E-5 ERAD & cell cycle 45 1.49E-4
13 SGTC_1745 st081495 3.57 74.0 µM 4.22E-5 RNA processing & uracil transport 87 1.78E-4
14 SGTC_1606 st000094 3.57 49.2 µM 4.25E-5 60S ribosome export 30 1.79E-4
15 SGTC_784 4579-0127 3.51 173.0 µM 5.69E-5 38 2.28E-4
16 SGTC_589 1227-0070 3.50 34.1 µM 5.91E-5 40 2.35E-4
17 SGTC_214 4373-3496 3.43 70.0 µM 7.84E-5 96 2.98E-4
18 SGTC_2605 digitonin 3.38 300.0 nM 9.98E-5 53 3.64E-4
19 SGTC_2704 st078022 3.26 71.1 µM 1.68E-4 30 5.63E-4
20 SGTC_2285 7945142 3.25 200.0 µM 1.70E-4 44 5.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.67E-19 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.144 5.01E-17 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.141 2.03E-16 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.130 4.00E-14 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.126 2.43E-13 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.122 1.96E-12 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.112 6.79E-11 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.105 1.25E-9 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.100 7.03E-9 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.097 1.71E-8 YFR045W_p YFR045W_p hom Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
0.088 3.11E-7 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.087 3.85E-7 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.80E-7 YPR105C COG4 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.087 4.81E-7 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.087 5.28E-7 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane