YJR094C / IME1

Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR094C / IME1

Click on Significant Values for Screen Details ID:SGTC_193|Compound:1273-0060|FD-Score:2.87|P-value:4.16E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.74|P-value:7.17E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:2.81|P-value:5.49E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:8.23|P-value:5.61E-22 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.76|P-value:6.59E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.51|P-value:7.74E-8 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.61|P-value:1.34E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.87|P-value:3.33E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.11|P-value:1.47E-4 ID:SGTC_458|Compound:nppb|FD-Score:2.99|P-value:2.51E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:2.93|P-value:3.35E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.17|P-value:6.23E-7 ID:SGTC_696|Compound:1560-0013|FD-Score:2.71|P-value:8.10E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.31|P-value:5.80E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.06|P-value:1.88E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.09|P-value:1.67E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:2.84|P-value:4.72E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:2.82|P-value:5.21E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.25|P-value:7.80E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:3.48|P-value:2.66E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.05|P-value:1.24E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-2.70|P-value:8.51E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.36|P-value:1.97E-7 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.65|P-value:1.11E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:8.07|P-value:3.33E-21 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.25|P-value:3.87E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.79|P-value:5.31E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.10|P-value:1.57E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.86|P-value:4.41E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.48|P-value:2.59E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.14|P-value:1.29E-4 ID:SGTC_1741|Compound:st038134|FD-Score:2.84|P-value:4.78E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-2.69|P-value:8.75E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.14|P-value:1.28E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.79|P-value:5.34E-6 ID:SGTC_2121|Compound:5257820|FD-Score:3.22|P-value:8.87E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.43|P-value:3.36E-5 ID:SGTC_2253|Compound:7938677|FD-Score:2.73|P-value:7.46E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.02|P-value:1.50E-6 ID:SGTC_2318|Compound:6029776|FD-Score:2.75|P-value:7.00E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-2.91|P-value:3.63E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.31|P-value:5.85E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.67|P-value:1.00E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-2.72|P-value:7.74E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.49|P-value:2.49E-5 ID:SGTC_2692|Compound:st077426|FD-Score:2.86|P-value:4.40E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.82|P-value:4.40E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.35|P-value:4.91E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-4.01|P-value:1.54E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-2.76|P-value:6.61E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:2.87|P-value:4.16E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.74|P-value:7.17E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:2.81|P-value:5.49E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:8.23|P-value:5.61E-22 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.76|P-value:6.59E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.51|P-value:7.74E-8 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.61|P-value:1.34E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.87|P-value:3.33E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.11|P-value:1.47E-4 ID:SGTC_458|Compound:nppb|FD-Score:2.99|P-value:2.51E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:2.93|P-value:3.35E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.17|P-value:6.23E-7 ID:SGTC_696|Compound:1560-0013|FD-Score:2.71|P-value:8.10E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.31|P-value:5.80E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.06|P-value:1.88E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.09|P-value:1.67E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:2.84|P-value:4.72E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:2.82|P-value:5.21E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.25|P-value:7.80E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:3.48|P-value:2.66E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.05|P-value:1.24E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-2.70|P-value:8.51E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.36|P-value:1.97E-7 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.65|P-value:1.11E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:8.07|P-value:3.33E-21 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.25|P-value:3.87E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.79|P-value:5.31E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.10|P-value:1.57E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.86|P-value:4.41E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.48|P-value:2.59E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.14|P-value:1.29E-4 ID:SGTC_1741|Compound:st038134|FD-Score:2.84|P-value:4.78E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-2.69|P-value:8.75E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.14|P-value:1.28E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.79|P-value:5.34E-6 ID:SGTC_2121|Compound:5257820|FD-Score:3.22|P-value:8.87E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.43|P-value:3.36E-5 ID:SGTC_2253|Compound:7938677|FD-Score:2.73|P-value:7.46E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.02|P-value:1.50E-6 ID:SGTC_2318|Compound:6029776|FD-Score:2.75|P-value:7.00E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-2.91|P-value:3.63E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.31|P-value:5.85E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.67|P-value:1.00E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-2.72|P-value:7.74E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.49|P-value:2.49E-5 ID:SGTC_2692|Compound:st077426|FD-Score:2.86|P-value:4.40E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.82|P-value:4.40E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.35|P-value:4.91E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-4.01|P-value:1.54E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-2.76|P-value:6.61E-4

Top fitness defect scores for YJR094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_345 1362-0200 8.23 395.0 µM 5.61E-22 1 9.71E-17
2 SGTC_996 3970-0799 8.07 1.8 µM 3.33E-21 21 3.64E-16
3 SGTC_953 1188-0045 4.36 9.7 µM 1.97E-7 60S ribosome export 21 6.46E-6
4 SGTC_1121 fusaric acid 4.25 630.5 nM 3.87E-7 23 1.07E-5
5 SGTC_669 0108-0021 4.17 26.2 µM 6.23E-7 fatty acid desaturase (OLE1) 71 1.53E-5
6 SGTC_2316 5844804 4.02 197.4 µM 1.50E-6 26 2.95E-5
7 SGTC_2693 st077581 3.82 40.7 µM 4.40E-6 41 6.61E-5
8 SGTC_1132 3456-3614 3.79 2.5 µM 5.31E-6 tubulin folding & SWR complex 57 7.61E-5
9 SGTC_2107 5363541 3.79 170.2 µM 5.34E-6 11 7.64E-5
10 SGTC_2514 salinomycin 3.67 42.7 µM 1.00E-5 57 1.23E-4
11 SGTC_2602 kawain 3.49 100.0 µM 2.49E-5 42 2.42E-4
12 SGTC_1715 st032160 3.48 10.2 µM 2.59E-5 57 2.50E-4
13 SGTC_940 3232-1287 3.48 54.8 µM 2.66E-5 NEO1 56 2.55E-4
14 SGTC_783 0848-0141 3.31 92.7 µM 5.80E-5 RSC & ERG11 27 4.59E-4
15 SGTC_877 0771-0151 3.25 33.1 µM 7.80E-5 28 5.73E-4
16 SGTC_2121 5257820 3.22 149.6 µM 8.87E-5 30 6.31E-4
17 SGTC_426 0988-0037 3.11 14.6 µM 1.47E-4 ERAD & cell cycle 74 9.25E-4
18 SGTC_1177 0983-0204 3.10 23.6 µM 1.57E-4 39 9.70E-4
19 SGTC_790 1575-0012 3.09 79.1 µM 1.67E-4 TSC3-RPN4 67 0.00102
20 SGTC_458 nppb 2.99 133.0 µM 2.51E-4 45 0.00138

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.357 2.96E-101 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.330 4.84E-86 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.291 1.79E-66 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.275 4.00E-59 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.274 1.25E-58 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.270 5.66E-57 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.255 3.94E-51 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.230 2.39E-41 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.229 3.58E-41 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.222 6.74E-39 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.220 4.83E-38 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.198 4.49E-31 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.191 5.07E-29 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.191 8.81E-29 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.186 1.59E-27 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase