YJR094W-A / RPL43B

Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR094W-A / RPL43B

Click on Significant Values for Screen Details ID:SGTC_276|Compound:colchicine|FD-Score:3.88|P-value:1.37E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.25|P-value:2.17E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:2.92|P-value:7.98E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.91|P-value:8.14E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-5.26|P-value:8.62E-9 ID:SGTC_877|Compound:0771-0151|FD-Score:4.63|P-value:2.88E-7 ID:SGTC_981|Compound:1488-1094|FD-Score:3.19|P-value:2.79E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.23|P-value:2.41E-6 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.07|P-value:5.15E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.14|P-value:3.97E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.34|P-value:1.81E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.96|P-value:6.85E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.95|P-value:6.96E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.73|P-value:3.26E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.33|P-value:1.59E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:-3.05|P-value:5.58E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.79|P-value:2.48E-5 ID:SGTC_1647|Compound:st011722|FD-Score:3.01|P-value:5.70E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-2.92|P-value:9.08E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.89|P-value:6.65E-8 ID:SGTC_2025|Compound:5147754|FD-Score:3.08|P-value:4.25E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.27|P-value:2.03E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.61|P-value:5.79E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-4.87|P-value:9.08E-8 ID:SGTC_2121|Compound:5257820|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-5.87|P-value:1.57E-10 ID:SGTC_2135|Compound:5326629|FD-Score:-3.46|P-value:1.11E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-2.90|P-value:9.95E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.08|P-value:4.36E-4 ID:SGTC_2304|Compound:7443016|FD-Score:3.26|P-value:2.15E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.03|P-value:5.32E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.14|P-value:4.01E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.18|P-value:2.89E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.33|P-value:1.58E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.05|P-value:5.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.44|P-value:1.21E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.41|P-value:1.32E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.27|P-value:2.46E-6 ID:SGTC_2784|Compound:7567673|FD-Score:-3.48|P-value:1.02E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.96|P-value:1.15E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.02|P-value:6.34E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.13|P-value:3.49E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.84|P-value:1.65E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.41|P-value:1.33E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.21|P-value:2.55E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.88|P-value:1.37E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.25|P-value:2.17E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:2.92|P-value:7.98E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.91|P-value:8.14E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-5.26|P-value:8.62E-9 ID:SGTC_877|Compound:0771-0151|FD-Score:4.63|P-value:2.88E-7 ID:SGTC_981|Compound:1488-1094|FD-Score:3.19|P-value:2.79E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.23|P-value:2.41E-6 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.07|P-value:5.15E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.14|P-value:3.97E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.34|P-value:1.81E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.96|P-value:6.85E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.95|P-value:6.96E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.73|P-value:3.26E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.33|P-value:1.59E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:-3.05|P-value:5.58E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.79|P-value:2.48E-5 ID:SGTC_1647|Compound:st011722|FD-Score:3.01|P-value:5.70E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-2.92|P-value:9.08E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.89|P-value:6.65E-8 ID:SGTC_2025|Compound:5147754|FD-Score:3.08|P-value:4.25E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.27|P-value:2.03E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.61|P-value:5.79E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-4.87|P-value:9.08E-8 ID:SGTC_2121|Compound:5257820|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-5.87|P-value:1.57E-10 ID:SGTC_2135|Compound:5326629|FD-Score:-3.46|P-value:1.11E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-2.90|P-value:9.95E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.08|P-value:4.36E-4 ID:SGTC_2304|Compound:7443016|FD-Score:3.26|P-value:2.15E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.03|P-value:5.32E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.14|P-value:4.01E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.18|P-value:2.89E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.33|P-value:1.58E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.05|P-value:5.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.44|P-value:1.21E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.41|P-value:1.32E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.27|P-value:2.46E-6 ID:SGTC_2784|Compound:7567673|FD-Score:-3.48|P-value:1.02E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.96|P-value:1.15E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-3.02|P-value:6.34E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.13|P-value:3.49E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.84|P-value:1.65E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.41|P-value:1.33E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.21|P-value:2.55E-4

Top fitness defect scores for YJR094W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2024 5144227 4.89 134.0 µM 6.65E-8 17 5.10E-7
2 SGTC_877 0771-0151 4.63 33.1 µM 2.88E-7 9 1.81E-6
3 SGTC_996 3970-0799 4.23 1.8 µM 2.41E-6 73 1.15E-5
4 SGTC_276 colchicine 3.88 750.0 µM 1.37E-5 20 5.18E-5
5 SGTC_3061 glucosamine 3.84 200.0 µM 1.65E-5 12 6.08E-5
6 SGTC_2569 tetrandrine 3.33 100.0 µM 1.58E-4 47 4.31E-4
7 SGTC_1289 0976-0073 3.33 69.1 µM 1.59E-4 26 4.34E-4
8 SGTC_2456 5770359 3.28 74.5 µM 1.93E-4 34 5.13E-4
9 SGTC_2042 p-Dimethylaminoacetophenone 3.27 200.0 µM 2.03E-4 45 5.38E-4
10 SGTC_2304 7443016 3.26 91.4 µM 2.15E-4 40 5.65E-4
11 SGTC_827 3253-0474 3.25 693.0 µM 2.17E-4 46 5.69E-4
12 SGTC_3242 9133940 3.21 49.5 µM 2.55E-4 32 6.55E-4
13 SGTC_981 1488-1094 3.19 54.9 µM 2.79E-4 44 7.08E-4
14 SGTC_2563 tomatine 3.18 8.5 µM 2.89E-4 92 7.29E-4
15 SGTC_2967 9089538 3.13 49.9 µM 3.49E-4 71 8.60E-4
16 SGTC_2025 5147754 3.08 141.0 µM 4.25E-4 31 0.00102
17 SGTC_2292 7671323 3.08 168.1 µM 4.36E-4 RNA processing & uracil transport 79 0.00104
18 SGTC_2121 5257820 3.06 149.6 µM 4.73E-4 39 0.00112
19 SGTC_2306 7482397 3.03 179.5 µM 5.32E-4 RPP1 & pyrimidine depletion 61 0.00124
20 SGTC_1647 st011722 3.01 22.4 µM 5.70E-4 36 0.00132

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.17E-25 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.141 1.78E-16 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.138 1.25E-15 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.133 1.06E-14 YHR180W_d YHR180W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.125 3.27E-13 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.117 1.12E-11 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.116 1.90E-11 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.116 1.92E-11 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.113 5.69E-11 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.108 3.54E-10 YGL207W SPT16 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
0.104 1.31E-9 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.100 5.83E-9 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.099 9.17E-9 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.099 9.69E-9 YLR013W GAT3 hom Protein containing GATA family zinc finger motifs
0.099 1.04E-8 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear