HIPHOP chemogenomics database
YJR099W / YUH1 
Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YJR099W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.187 | 9.07E-28 | YGR217W | CCH1 | hom | Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together |
| 0.170 | 4.85E-23 | YFL027C | GYP8 | hom | GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport |
| 0.169 | 7.59E-23 | YPL027W | SMA1 | hom | Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p |
| 0.166 | 2.88E-22 | YBR139W | YBR139W | hom | Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner |
| 0.160 | 9.11E-21 | YBR108W | AIM3 | hom | Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss |
| 0.158 | 3.06E-20 | YKL187C | FAT3 | hom | Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies |
| 0.155 | 1.30E-19 | YBR169C | SSE2 | hom | Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication |
| 0.143 | 9.90E-17 | YMR118C_p | SHH3_p | hom | Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase |
| 0.142 | 1.29E-16 | YNL086W_p | SNN1_p | hom | Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes |
| 0.127 | 1.32E-13 | YBR239C_p | ERT1_p | hom | Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition |
| 0.126 | 2.39E-13 | YNL105W_d | RRT16_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription |
| 0.124 | 6.75E-13 | YJL136W-A_p | YJL136W-A_p | hom | Putative protein of unknown function; identified by SAGE |
| 0.119 | 4.34E-12 | YGL262W_p | YGL262W_p | hom | Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene |
| 0.114 | 3.08E-11 | YLR251W | SYM1 | hom | Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 |
| 0.112 | 6.84E-11 | YOR268C_p | YOR268C_p | hom | Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene |